(v. t.) To make otherwise; to change in some respect, either partially or wholly; to vary; to modify.
(v. t.) To agitate; to affect mentally.
(v. t.) To geld.
(v. i.) To become, in some respects, different; to vary; to change; as, the weather alters almost daily; rocks or minerals alter by exposure.
Example Sentences:
(1) Herpesviruses such as EBV, HSV, and human herpes virus-6 (HHV-6) have a marked tropism for cells of the immune system and therefore infection by these viruses may result in alterations of immune functions, leading at times to a state of immunosuppression.
(2) The process of sequence rearrangement appears to be a significant part of the evolution of the genome and may have a much greater effect on the evolution of the phenotype than sequence alteration by base substitution.
(3) The various evocational changes appear to form sets of interconnected systems and this complex network seems to embody some plasticity since it has been possible to suppress experimentally some of the most universal evocational events or alter their temporal order without impairing evocation itself.
(4) When chimeric animals were subjected to a lethal challenge of endotoxin, their response was markedly altered by the transferred lymphoid cells.
(5) Morphological alterations in the lungs of pheasants after prolonged high-dosage administration of bleomycin sulfate were studied by light and electron microscopy.
(6) Incubation with IFN alpha or IFN gamma for 24 h resulted in only modest cytokinetic alterations, and they did not modify the effects of FUra.
(7) We report a series of experiments designed to determine if agents and conditions that have been reported to alter sodium reabsorption, Na-K-ATPase activity or cellular structure in the rat distal nephron might also regulate the density or affinity of binding of 3H-metolazone to the putative thiazide receptor in the distal nephron.
(8) In dorsoventral (DV) reversed wings at both shoulder or flank level, the motor axons do not alter their course as they enter the graft.
(9) Neither spermidine nor spermine (0.5 mM) significantly altered [Ca2+]i.
(10) In addition to the changes associated with blood group A, we also found a decrease in sugar content, alterations in other antigens, and changes in the levels of several glycosyltransferases in cancerous tissues.
(11) When the concentration of thrombin or fibrinogen was altered systematically, mu T and mup were found to mirror each other except when the fibrinogen concentration was increased at low thrombin concentrations.
(12) Arteries treated with atrial natriuretic peptide showed no alterations in relaxation or cGMP content after incubation with pertussis toxin.
(13) These results could be explained by altered tissue blood flow and a decreased metabolic capacity of the liver in obese subjects.
(14) The sequential histopathologic alterations in femorotibial joints of partial meniscectomized male and female guinea pigs were evaluated at 1, 2, 3, 6, and 12 weeks post-surgery.
(15) However, survival was closely related to the severity of the illness at the time of randomization and was not altered by shunting.
(16) Brain damage may be followed by a number of dynamic events including reactive synaptogenesis, rerouting of axons to unusual locations and altered axon retraction processes.
(17) Since the advance and return of sperm inside the tubes could facilitate the interaction of sperm with secretions participating in its maturation, the persistent infertility after vasectomy could be related to the contractile alteration that follows the excessive tubal distention.
(18) Sixteen patients (27%) manifested anomalies of the urinary tract: 12 had markedly altered kidneys, 8 of which were unilateral and ipsilateral to the diaphragmatic defect.
(19) Corticosterone (4 x 10(-5) M) did not alter the stimulation-evoked 3H-overflow at 1-30 Hz.
(20) The results show that the presence of histones does not alter the bimodal DNA binding process.
Sophisticate
Definition:
(v. t.) To render worthless by admixture; to adulterate; to damage; to pervert; as, to sophisticate wine.
(a.) Alt. of Sophisticated
Example Sentences:
(1) "With the advent of sophisticated data-processing capabilities (including big data), the big number-crunchers can detect, model and counter all manner of online activities just by detecting the behavioural patterns they see in the data and adjusting their tactics accordingly.
(2) A developing sophistication on the part of both children and parents, coupled with a rapidly expanding recognition of the need to minimize the amount of physical and psychological trauma that a child has to experience, has led to a growing use of premedication agents for children.
(3) The initial defect can be directly measured by glucose clamp and other sophisticated techniques; the clinical syndrome may be derived from a network of related variables known to be associated with reduced insulin action.
(4) While simple assays of complex I activity are unlikely to be useful in the preclinical detection of Parkinson's disease, other more sophisticated physical-chemical approaches including detection of free radical damage may have utility.
(5) This is not some sophisticated, Westminstery battle, but a life-and-death, misery-or-decency choice about the very basics of life for hundreds of thousands of older British people.
(6) While the high sophistication subjects rated the interpretation as accurate across validity conditions, the low sophistication subjects rated the interpretation according to the validity instructions they received.
(7) Lateralization may be an expression of reflex constraints bound initially to the infant's tonic-neck posture, with later development less reflex-patterned during the acquisition of more sophisticated information-processing strategies.
(8) A simple multiband volume control is expected to provide much of the benefit of more sophisticated systems without the need for separate estimation of input speech and noise spectra.
(9) What’s imperative from an organizational standpoint, he added, is “understanding where voters are, what their concerns are, and building a sophisticated operation around that.
(10) The laws of functioning applicable to these approaches are those coming from liberal and planified economical theories while health planning has developed more and more sophisticated and convincing methodologies.
(11) Therefore, controlled hypotension, being a sophisticated technique, requires handling by an experienced anesthetist well aware of contraindications and the need for adequate monitoring for prevention of tissue ischemia.
(12) However, a homemade pipe bomb thrown at a police patrol in north Belfast earlier this year was described as of a new, sophisticated variety that the PSNI had not seen before.
(13) While numerous studies on infant perception have demonstrated the infant's ability to discriminate sounds having different frequencies, little research has evaluated more sophisticated pitch perception abilities such as perceptual constancy and perception of the missing fundamental.
(14) It is concluded that imaging of the urinary tract is not necessary for pure nightwetters, while ultrasonography or uroflowmetry and more sophisticated radiological or urological methods should be focused on those children with daytime wetting and clinical symptoms of voiding disturbances.
(15) When multiple database systems are present, a flexible front end can provide sophisticated querying capabilities that bridge the systems, while hiding the complexities of the multiple systems from the user.
(16) This validity coefficient turned out to be so high (r = 0.967) that it does not seem necessary to adopt a more sophisticated method, despite a few demonstrable shortcomings of the one in use.
(17) The comparison of drug responder and non-responder group has also been made more meaningful by the availability of more reliable methods of assessing clinical phenomena, more sophisticated diagnostic models and the introduction of other biological measures.
(18) The environment in the intensive therapy units (ITUs) has thus become increasingly sophisticated with the use of highly specialised equipment.
(19) Attempts to save parts of teeth go back 100 years or more, but it is the increased predictability of success of endodontic therapy and the increased sophistication of periodontal treatment that have given us the means to save molars with furcation problems that, otherwise, would be lost.
(20) The monitoring equipment gets more sophisticated and easier to use month by month.