What's the difference between anaemia and poikilocyte?
Anaemia
Definition:
(a.) A morbid condition in which the blood is deficient in quality or in quantity.
Example Sentences:
(1) This clinical improvement was also associated with a decrease of erythrocyte sedimentation rate (p less than 0.001), decrease of C-reactive protein (p less than 0.0001) and with improvement of anaemia (p less than 0.05).
(2) During this period he developed autoimmune haemolytic anaemia, a rare complication of myelofibrosis.
(3) Therapeutic possibilities for hepatogenous anaemia of complex genesis are discussed.
(4) The presenting feature was an anaemia unresponsive to usual therapy.
(5) Haematological findings in 9 dogs with splenic or hepatic haemangiosarcoma included a mild to moderate normochromic anaemia, neutrophilia, thrombocytopaenia, poikilocytosis and increased target cells.
(6) The authors describe an unusual case of hypoplastic anaemia.
(7) In some normal and iron deficient subjects the GSH-Px activity in the youngest erythrocyte fraction was equal or lower than that previously found in whole erythrocytes of patients affected by haemolytic anaemia.
(8) The infection responded to oxytetracycline and the anaemia subsequently resolved.
(9) In the patients with aplastic anaemia the iron flux was diminished, but never eliminated, demonstrating that the exchangeable compartment was not solely erythroblastic, but included non-erythroid transferrin receptors.
(10) This suggests that there is little survival advantage or disadvantage in the combination of glucose-6-phosphate dehydrogenase deficiency and sickle cell anaemia.
(11) However, in most cases red cell synthesis was less than expected from the degree of anaemia, suggesting impairment of bone marrow function.
(12) There was a significant reduction in all colony types in patients with aplastic anaemia when compared with normal controls.
(13) These experimental results demonstrate that aluminium interferes with iron absorption and iron transfer, and suggest that these mechanisms may be responsible for maintaining and even increasing the anaemia observed in aluminium overload.
(14) The antibody was complement-fixing 19S IgM and showed a high thermal range but no detectable haemolytic anaemia was associated.
(15) There was a 25-year history of normochromic normocytic anaemia with moderate basophilic stippling, mild renal failure, hyperuricaemia and abnormal porphyrins.
(16) In view of this, the development of anaemia seems likely to result from the altered iron metabolism induced by stimulated macrophages.
(17) The variation of total Hb in the study population was due, as far as could be defined, only to beta-th-t and a superimposed iron deficiency anaemia (IDA).
(18) Aplastic anaemia and megaloblastic anaemia patients revealed significant differences in the incidence of hepatosplenomegaly, anisocytosis, circulating erythroblasts, relative lymphocytosis (P < 0.001 for all) and reticulocytosis (P < 0.01).
(19) Iron deficiency has been tentatively excluded as a cause of this anaemia by measurement of serum ferritin levels.
(20) Persistent infection with parvovirus (B19) causing severe anaemia has been reported in patients with leukaemia and congenital immunodeficiency.
Poikilocyte
Definition:
(n.) An irregular form of corpuscle found in the blood in cases of profound anaemia, probably a degenerated red blood corpuscle.
Example Sentences:
(1) In both studies, the poikilocytes were identified as echinocytes, spiculated erythrocytes, and schizocytes.
(2) Spiculated poikilocytes occur in several different forms.
(3) Light microscopic studies indicated that approximately one-fifth as much urea is required to block sickling as is necessary to reverse sickled poikilocytes to normal forms.
(4) Calves less than six weeks of age had more poikilocytes, lower serum iron, higher total iron binding capacity, less adult hemoglobin and more neonatal and fetal hemoglobin than calves greater than six weeks of age.
(5) Bite cells are morphologically characterized as poikilocytes with one or more semicircular portions removed from the cell margin.
(6) Sensibilization has resulted in the rise of echinocyte, poikilocyte and schizocyte blood level.
(7) A kindred is described in which two brothers with a poikilocytic variant of hereditary elliptocytosis (HE) were found to have a defect of spectrin dimer association and a decreased spectrin-band 3 ratio.
(8) Clinical expression of HE in these families ranges from mild elliptocytosis without hemolysis to severe poikilocytic hemolytic anemia clinically resembling HPP.
(9) Thus, co-inheritance of two alpha spectrin defects can result in a poikilocytic hemolytic anemia milder than that usually found in HPP.
(10) We propose that the patients' red-cell morphology is the result of in vivo fragmentation, and that the spleen is the major site of microspherocyte and poikilocyte destruction.
(11) Poikilocytes were strongly inversely correlated (-0.9177) with age.
(12) Scanning electron micrographs showed a reversion of sickled poikilocytes to a normal erythrocyte population of biconcave discs.
(13) The blood of the subjects contained discoid erythrocytes, poikilocytes, and showed considerable anisocytosis.
(14) Occasional nonspecific poikilocytes are found in most normal blood smears, but dominance of one or more forms of poikilocytes usually is indicative of a specific anemia or disease in an organ or organ system.
(15) The action of constant current (0.01-3 A, 1-25 V) on human blood during varying exposures induced intensified plaque-formation in the preparations of the local hemolysis test, and transformation of red blood cells-discocytes into echino- and poikilocytes that was attended by pronounced changes in the extent, intensity of light diffusion, natural green and red luminescence of red blood cells caused by flavoproteins and metalloporphyrins.
(16) The clinical significance of the various round poikilocytes (spherocytes, stomatocytes, target cells) and elongated poikilocytes (ovalocytes and elliptocytes, teardrop cells, sickle cells) is discussed.
(17) The red cell morphology varies correspondingly from smooth elliptocytes to predominantly poikilocytes.
(18) In groups B and C, clinical signs of lead poisoning were mild, nonpersistent anemia characterized by the presence of poikilocytes, hupochromic erythrocytes, target cells, erythroblasts, erythrocytes with punctate basophilic stippling, reduced mean corpuscular hemoglobin concentrations, and relative lymphocytosis, neutropenia, and eosinopenia.
(19) We conclude that the abnormality in the alpha I domain originally described in HPP spectrin is shared by a subset of patients with HE; the severity of clinical expression, ranging from mild nonhemolytic HE to poikilocytic hemolytic anemia, is related to the fractional quantity of the alpha subunit that is affected.