(n.) An organic base belonging to the phenylamines. It may be regarded as ammonia in which one hydrogen atom has been replaced by the radical phenyl. It is a colorless, oily liquid, originally obtained from indigo by distillation, but now largely manufactured from coal tar or nitrobenzene as a base from which many brilliant dyes are made.
(a.) Made from, or of the nature of, aniline.
Example Sentences:
(1) Pretreatment of rats with 6-(3-picolyl)amino-2,2,5,8-tetramethylchromane (PATC) for 7 days resulted in a significant increase in the activities of benzphetamine N-demethylase, p-nitroanisole O-demethylase and aniline hydroxylase in liver microsomes prepared 24 h after the last treatment.
(2) Comparison of the specific activities for aniline hydroxylation and p-nitrophenol hydroxylation of individual microsomal samples from control, ethanol-pretreated and phenobarbital-pretreated animals showed a high degree of correlation (r2 = 0.98) consistent with the involvement of the same site for catalysis of these two compounds.
(3) Chlordimeform had no effect on the cytochrome P-450 content, aniline p-hydroxylase or glutathione S-transferase activities, but induced ethoxyresorufin-O-deethylase, ethoxycoumarin-O-deethylase and epoxide hydrolase activities and decreased aldrin epoxidase and aminopyrine N-demethylase activities.
(4) Intestinal aniline hydroxylation was refractory to ethanol induction.
(5) Incubation of aniline-metabolizing hepatocytes with disulfiram resulted in decreased formation of 4-aminophenol, but this was not associated with impaired glucuronidation or cytochrome P-450 levels.
(6) At 20 degrees C, in a phosphate buffer, pH 5,8--8,0, methanol and aniline interactions with hemoglobin and cytochrome c were studied using the difference spectrophotometry method.
(7) Activities of amidopyrine N-demethylase, aniline hydroxylase, NADPH, cytochrome c reductase as well as content of cytochromes P-450 and b5 were studied in liver tissue of rats within 1, 3, 7, 10, 20 and 30 days of hypokinesia caused by maintaining of the animals in individual cell-cases.
(8) In contrast, menadione does not change the type II binding spectrum induced by aniline.
(9) Enzymatic polymerization took place on the surface of BOD-adsorbed solid matrix which was in contact with a buffer solution containing aniline.
(10) In NADPH-containing microsomal systems with 4-fluoro-substituted anilines, formation of the 4-hydroxyaniline derivative is observed because NADPH chemically reduces this quinoneimine metabolite.
(11) The activity of aniline hydroxylase was significantly increased in liver microsomes of EHBR whereas the activity of ethylmorphine N-demethylase was found to be significantly decreased in EHBR as compared to control rats.
(12) When compared to the first day, methemoglobin (MetHb) levels, measured prior to and following the exposure, increased with the days of exposure at 50 ppm aniline.
(13) Although metabolic attack occurred adjacent to either the aniline nitrogen or the aliphatic amine, metabolic attack occurred primarily adjacent to the more basic nitrogen at the 1'-position, even when this position bore a methyl substituent.
(14) Carbon monoxide inhibits the hydroxylase activity of the tissue-free system to a smaller extent than that of a system containing microsomes plus haemoglobin whereas p-chloromercuribenzoate inhibits only the flavoprotein-dependent hydroxylation of aniline mediated by haemoglobin.
(15) The profiles of urinary metabolites produced by rats and mice were not appreciably different in animals predosed with aniline.
(16) The results indicate that aniline degrading populations of these various microbial communities exhibit different activities probably depending on the extent of adaptation to pollutants to which the microbes are exposed.
(17) A high-pressure liquid chromatographic method has been developed for the determination of nanomole quantities of aniline; its metabolites o- and p-aminophenol, phenylhydroxylamine, nitrosobenzene and nitrobenzene; and azobenzene and azoxybenzene which form non-enzymatically by condensation of reactive metabolites.
(18) A series of ortho-quinone analogues 1-28 of podophyllotoxin possessing various C-4 beta-aniline moieties have been synthesized and evaluated for their inhibitory activity against human DNA topoisomerase II, their activity in causing cellular protein-linked DNA breakage, and their cytotoxicity against KB cells.
(19) The inhibitory effect of the nitroso-compound is demonstrated to be non-competitive on aminopyrine N-demethylase, p-nitroanisole O-demethylase and aniline hydroxylase.
(20) Compared with the control values, the levamisole treatment significantly increased the amount of cytochrome P450 and cytochrome b5 and the in-vitro activities of aminopyrine N-demethylase, benzphetamine N-demethylase and aniline hydroxylase.
Indigo
Definition:
(n.) A kind of deep blue, one of the seven prismatic colors.
(n.) A blue dyestuff obtained from several plants belonging to very different genera and orders; as, the woad, Isatis tinctoria, Indigofera tinctoria, I. Anil, Nereum tinctorium, etc. It is a dark blue earthy substance, tasteless and odorless, with a copper-violet luster when rubbed. Indigo does not exist in the plants as such, but is obtained by decomposition of the glycoside indican.
(a.) Having the color of, pertaining to, or derived from, indigo.
Example Sentences:
(1) Mood Indigo (18 July) Arguably the most French movie ever made, Romain Duris and Audrey Tautou are quite adorable as fairy tale lovers in Michel Gondry's adaptation of Boris Vian's Froth on the Daydream.
(2) Among the latter, there were sensitizations, to our knowledge hitherto unreported in the literature: to indigo carmine (2 cases), monensin sodium (1 case), thiabendazole (1 case), methylchlorpindol (1 case) and amprolium hydrochloride (1 case).
(3) Over a crest in the road was the cause of the electronic silence: the National Radio Astronomy Observatory (NRAO), an array of radio telescopes set against the indigo vastness of the Blue Ridge Mountains.
(4) The enzymatic activity was revealed by reddish-brown, purple red, and indigo-blue cytoplasmic precipitate, using the substrates alpha-naphthyl-acetate, naphthol-AS acetate and 5-bromo-4-chloro-indoxyl acetate respectively.
(5) We conclude that avoiding of xylene, and mounting of the preparates in Histoclear (a xylene substitute) and Canada balsam (instead of synthetic resin mountants) yields a sharp and stable indigo precipitate.
(6) The plantations of the Carolina Low Country produced rice, indigo and cotton.
(7) Synthetic indigo, indirubin and isatin were tested for TCDD receptor affinity in competition experiments in vitro.
(8) When injected with indigo carmine, the vessels localized by the hydrogen-induced current impulses filled the entire anterior spinal artery from the low thoracic to the sacral region, whereas injection of the other vessels did not show filling.
(9) beta-galactosidase, revealed by an indigo blue reaction product, represents a valid tracer in immunohistochemistry.
(10) Chromosomal aberrations induced by indigo carmine (secondary amine-containing dye), fast green FCF (tertiary amine-containing dye) and sodium nitrite, singly and in combination, were studied in mice after prolonged feeding in the diet.
(11) Following aspirate cytology, the lesion was localized with indigo carmine and Kopans' wire and every patient underwent a standard open excisional biopsy.
(12) Observations on the instability of the indigo precipitate led us to investigate this phenomenon.
(13) Synthetic indigo of technical grade or 98% pure showed mutagenic effects, especially on TA98 + S9.
(14) A trichrome staining technique using safranin-indigo-picrocarmine (SIPC) can be used to distinguish the various stages of the cell cycle in onion root tip.
(15) He was hooked the moment he heard Mood Indigo on his grandparents' wireless set at the age of five: "Something about it made my ears tingle."
(16) A central region of 2.9 kbp complemented an xylA (for xylene oxygenase) mutant of Pseudomonas putida mt-2 and was also capable of conferring the ability to convert indole to indigo on strains of Escherichia coli and P. putida.
(17) No hemodynamic instability occurred during the operation until the patient was administered intravenous (IV) indigo carmine 5 ml.
(18) Until further studies defining the mechanism for its hypertensive side effect are performed, indigo carmine should be used with caution in patients with severe cardiac dysfunction.
(19) Later, at Burberry , models walked the catwalk in buttoned-up indigo jackets and matching jeans.
(20) However, indigo showed a high (Kd = 1.9 nM) affinity for the Ah or TCDD receptor.