(n.) One who contends with another, especially in combat; an adversary; an opponent.
(n.) A muscle which acts in opposition to another; as a flexor, which bends a part, is the antagonist of an extensor, which extends it.
(n.) A medicine which opposes the action of another medicine or of a poison when absorbed into the blood or tissues.
(a.) Antagonistic; opposing; counteracting; as, antagonist schools of philosophy.
Example Sentences:
(1) This death is also dependent on the presence of chloride and is prevented with the non-selective EAA antagonist, kynurenic acid, but is not prevented by QA.
(2) Microionophoretically applied excitatory amino acids induced firing of extracellularly recorded single units in a tissue slice preparation of the mouse cochlear nucleus, and the similarly applied antagonist 2-amino-5-phosphonovalerate (2APV) was demonstrated to be a selective N-methyl-D-aspartate (NMDA) receptor antagonist.
(3) Meanwhile the efficiency of muscarinic antagonists in inhibition of tremor reaction induced by arecoline administration is associated with interaction between the drugs and the M2-subtype.
(4) The anticonvulsant properties of the endogenous excitatory amino acid antagonist, kynurenic acid (KYA), were studied in prepubescent and adult rats using the amygdaloid kindling model of epilepsy.
(5) A novel bicyclic prostaglandin analogue, (1S)-[1 alpha,2 alpha(Z),3 alpha,4 alpha]-7-[3-[(hexylthio)methyl]-7- oxabicyclo [2.2.1]hept-2-yl]-5-heptenoic acid ((-)-10), and its cogeners were found to be potent antagonists at the TxA2 receptor.
(6) This difference was abolished by exposure of the slices to propranolol, a beta-adrenergic receptor antagonist.
(7) The TxA2 antagonistic effects of KW-3635 were compared with that of daltroban in PRP from various animals species.
(8) In experiments performed to determine whether PtdIns(4,5)P2 hydrolysis induced by TRH may have been caused by the elevation of [Ca2+]i, the following results were obtained: the effect of TRH to decrease the level of PtdIns(4,5)P2 was not reproduced by the calcium ionophore A23187 or by membrane depolarization with 50 mM K+; the calcium antagonist TMB-8 did not inhibit the TRH-induced decrease in PtdIns(4,5)P2; and, most importantly, inhibition by EGTA of the elevation of [Ca2+]i did not inhibit the TRH-induced decrease in PtdIns(4,5)P2.
(9) Similarly, 50 microM D-600, a Ca+2 channel antagonist, significantly (P less than 0.01) reduced basal and 5-HETE-induced PRL release.
(10) Selective removal of endothelium had no effect on BK-induced contraction or the action of the antagonists.
(11) The second experiments entailed use of the nonspecific opiate antagonist, naloxone, as well as the specific delta antagonist, ICI 154,129, against seizures induced by icv-administered morphine, morphiceptin, DADL, or DSLET.
(12) These antagonists reverse NMDA-mediated long term influence in these brain areas.
(13) This novel mechanism of receptor regulation, named transmodulation, should be distinguished from the reduction in total receptor number caused by the homologous ligand (downregulation) and from the change in affinity produced by the binding of agonists or antagonists to the same receptor site.
(14) Furthermore, the ability of a vasopressin antagonist to lower arterial pressure in NTS hypertensive rats was markedly attenuated by clonidine treatment.
(15) All of the serotonergic antagonists studied had additional effects on the response of the coronary artery to electrical stimulation or to norepinephrine.
(16) Their receptive fields comprise a temporally and spatially linear mechanism (center plus antagonistic surround) that responds to relatively low spatial frequency stimuli, and a temporally nonlinear mechanism, coextensive with the linear mechanism, that--though broad in extent--responds best to high spatial-frequency stimuli.
(17) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(18) Addition in the cultures of 4-deoxypyridoxine, a potent antagonist of vitamin B6 coenzymes, concurrently with the mitogen, inhibits the induction of serine hydroxymethyltransferase.
(19) These results suggest that prevention of xenograft rejection using PAF-antagonist in association with other methods should be further investigated.
(20) The high concentrations of gonadotropins present in immature female rats by the end of the second week of life were suppressed by treatment with an antagonist against luteinizing hormone-releasing hormone (LHRH-A; Org.
Baddie
Definition:
Example Sentences:
(1) So strong is this image of Peck that his few honourable attempts at comedy, and his less successful portrayals of the baddie, are often forgotten.
(2) Call centre workers aren't cartoon baddies – it's rare that they've chosen to do this job.
(3) It was probably the seminal boxing match of all time, the dramatic unities perfectly in place: perceived goodie v baddie, impossible odds, totally unforeseen outcome.
(4) 12.44am BST Shadow finance minister Andrew Robb claims both Barack Obama and David Cameron have also used the word "baddies".
(5) There was, though, some indignation when it emerged both records had links to Simon Cowell , the entertainment industry's favourite pantomime baddy.
(6) With our politics increasingly polarised , it saddens me to see my students being initiated – deliberately or not – into an essentially Manichaean view of politics, with a checklist of “goodies” (leftists, trade unions, Corbyn) and “baddies” (Tories, Brexiteers, anyone who uses the phrase British values without irony).
(7) All this and Celia Imrie still comes close to stealing the show as a brilliant, sharp baddie.
(8) Photograph: Alan Markfield If Bruce isn't really Looper's baddie, it's only because black-and-white morality doesn't have a place in Johnson's world.
(9) But cackling local baddie Lawrence Murphy (Jack Palance) turns up to ruin their fun.
(10) Nor is there much sign of Thanos, the studio's go-to background baddie, though his minion Nebula turns up in the form of Doctor Who's shaven-headed Karen Gillan.
(11) On the rare occasions when you are depicted, it’s frequently as a disability stereotype – in a medical setting (toy hospital set), as an evil baddie (Captain Hook) or associated with charity (BBC’s Children in Need).
(12) Finland approves wolf hunt in trial cull Read more Thanks to people finally shrugging off the fairytale baddies that teach us to fear this carnivore, and thanks to protection from an EU directive on habitats, wolf numbers – along with those of lynx and brown bears – have been slowly recovering in Europe .
(13) As the tagline – "May the best man live" – suggests, it's basically the same old flick with the same old schtick: the Stath tops baddies, boffs toffs (he's a one-man manifesto for geezer supremacy), and cops off with a blondie.
(14) Bit too much like what the baddies on the other side would do, don’t you think?
(15) Dermot O'Leary is standing inside an illuminated ring of X Factor contestants, like he's one of the baddies from Superman II and he's about to be fired into space for his crimes.
(16) Many people will miss being the baddies, suggests Broder.
(17) To use his own language, a more accurate description would be: "It's not goodies versus baddies, it's a mixture of goodies and baddies versus baddies."
(18) We see some Somali baddies at the beginning disrupting a delivery of aid to Mogadishu - we are told they are doing it on General Aidid's orders and therefore the goodies (America) plan to kill General Aidid.
(19) Just because they're not the most imaginative of Whovian baddies.
(20) "Tinker Tailor rubbish, all moody non-dialogue and twisty plot that you desperately follow and then the denouement is cos the baddies are idiots and say something stupid - what's the point of the clever twisty plot when the goodies don't have to unravel it?"