(n.) One who contends with another, especially in combat; an adversary; an opponent.
(n.) A muscle which acts in opposition to another; as a flexor, which bends a part, is the antagonist of an extensor, which extends it.
(n.) A medicine which opposes the action of another medicine or of a poison when absorbed into the blood or tissues.
(a.) Antagonistic; opposing; counteracting; as, antagonist schools of philosophy.
Example Sentences:
(1) This death is also dependent on the presence of chloride and is prevented with the non-selective EAA antagonist, kynurenic acid, but is not prevented by QA.
(2) Microionophoretically applied excitatory amino acids induced firing of extracellularly recorded single units in a tissue slice preparation of the mouse cochlear nucleus, and the similarly applied antagonist 2-amino-5-phosphonovalerate (2APV) was demonstrated to be a selective N-methyl-D-aspartate (NMDA) receptor antagonist.
(3) Meanwhile the efficiency of muscarinic antagonists in inhibition of tremor reaction induced by arecoline administration is associated with interaction between the drugs and the M2-subtype.
(4) The anticonvulsant properties of the endogenous excitatory amino acid antagonist, kynurenic acid (KYA), were studied in prepubescent and adult rats using the amygdaloid kindling model of epilepsy.
(5) A novel bicyclic prostaglandin analogue, (1S)-[1 alpha,2 alpha(Z),3 alpha,4 alpha]-7-[3-[(hexylthio)methyl]-7- oxabicyclo [2.2.1]hept-2-yl]-5-heptenoic acid ((-)-10), and its cogeners were found to be potent antagonists at the TxA2 receptor.
(6) This difference was abolished by exposure of the slices to propranolol, a beta-adrenergic receptor antagonist.
(7) The TxA2 antagonistic effects of KW-3635 were compared with that of daltroban in PRP from various animals species.
(8) In experiments performed to determine whether PtdIns(4,5)P2 hydrolysis induced by TRH may have been caused by the elevation of [Ca2+]i, the following results were obtained: the effect of TRH to decrease the level of PtdIns(4,5)P2 was not reproduced by the calcium ionophore A23187 or by membrane depolarization with 50 mM K+; the calcium antagonist TMB-8 did not inhibit the TRH-induced decrease in PtdIns(4,5)P2; and, most importantly, inhibition by EGTA of the elevation of [Ca2+]i did not inhibit the TRH-induced decrease in PtdIns(4,5)P2.
(9) Similarly, 50 microM D-600, a Ca+2 channel antagonist, significantly (P less than 0.01) reduced basal and 5-HETE-induced PRL release.
(10) Selective removal of endothelium had no effect on BK-induced contraction or the action of the antagonists.
(11) The second experiments entailed use of the nonspecific opiate antagonist, naloxone, as well as the specific delta antagonist, ICI 154,129, against seizures induced by icv-administered morphine, morphiceptin, DADL, or DSLET.
(12) These antagonists reverse NMDA-mediated long term influence in these brain areas.
(13) This novel mechanism of receptor regulation, named transmodulation, should be distinguished from the reduction in total receptor number caused by the homologous ligand (downregulation) and from the change in affinity produced by the binding of agonists or antagonists to the same receptor site.
(14) Furthermore, the ability of a vasopressin antagonist to lower arterial pressure in NTS hypertensive rats was markedly attenuated by clonidine treatment.
(15) All of the serotonergic antagonists studied had additional effects on the response of the coronary artery to electrical stimulation or to norepinephrine.
(16) Their receptive fields comprise a temporally and spatially linear mechanism (center plus antagonistic surround) that responds to relatively low spatial frequency stimuli, and a temporally nonlinear mechanism, coextensive with the linear mechanism, that--though broad in extent--responds best to high spatial-frequency stimuli.
(17) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(18) Addition in the cultures of 4-deoxypyridoxine, a potent antagonist of vitamin B6 coenzymes, concurrently with the mitogen, inhibits the induction of serine hydroxymethyltransferase.
(19) These results suggest that prevention of xenograft rejection using PAF-antagonist in association with other methods should be further investigated.
(20) The high concentrations of gonadotropins present in immature female rats by the end of the second week of life were suppressed by treatment with an antagonist against luteinizing hormone-releasing hormone (LHRH-A; Org.
Competitor
Definition:
(n.) One who seeks what another seeks, or claims what another claims; one who competes; a rival.
(n.) An associate; a confederate.
Example Sentences:
(1) Mieko Nagaoka took just under an hour and 16 minutes to finish the race as the sole competitor in the 100 to 104-year-old category at a short course pool in Ehime, western Japan , on Saturday.
(2) That the BBC has probably not been as vulnerable since the 1980s is also true – not least because the enemies of impartiality are more powerful, and the BBC's competitors (maimed after a year's exposure of their own behaviour in the Leveson inquiry ) are keen to wreck it.
(3) It’s likely Xi’s brand of smart authoritarianism will keep not just his party in power but the whole show on the road If all this were to succeed as intended, western liberal democratic capitalism would have a formidable ideological competitor with worldwide appeal, especially in the developing world.
(4) CyIIIa.CAT) expression simultaneously in embryos bearing excess competitor regulatory DNA, we developed, and here describe, a new procedure for generating transgenic sea urchin embryos in which all of the cells in many embryos, and most in others, bear the exogenous DNA.
(5) Analysis of these human competitor proteins with homologous assay systems of viral core proteins and corresponding antisera showed that all, including the normal tissue extracts, appear similar to core proteins of known viruses, especially the RD 114 and woolly monkey species.
(6) The company lagged "far behind its major competitors, with zero reporting of its energy or environmental footprint to any source or stakeholder", the report said.
(7) These differences in hormonal responses to the fight are attributed to the more aggressive behavior displayed by the victorious opponents (winners) over their defeated competitors (losers).
(8) While it has not dominated the enormous mobile phone market in terms of sales – Apple has sold 41m handsets in three years, the same number Nokia sells in a month – it has won much of the more lucrative smartphone market, and drove its competitors to develop their own touchscreen handsets.
(9) Presenting his last set of results after 40 years with Britain 's largest mutual, Marks described 2012 as a "challenging year" but insisted that progress was being made on the Lloyds deal, which would triple the Co-op's branch network and transform the group into a major competitor to the big four banks.
(10) It also investigated the film market, looking at whether BSkyB's closer relationship with News Corp – which also owns the Hollywood studio 20th Century Fox – might enable it to buy up movies from the major US producers in order to prevent them being acquired by Sky's competitors.
(11) If backloading is not approved, this "floor price" could mean that UK businesses pay more for their emissions than continental European competitors.
(12) These results indicate that the use of serially diluted BPDE-DNA of high modification as standard competitor in the ELISA will lead to erroneous results in the measurement of adducts in DNAs modified to a low extent (biological samples).
(13) The region doesn't need more airport capacity; London already has more flights to the world's top business centres than any of its European competitors."
(14) It was clear, too, that they would need the kind of government support available to their competitors in countries such as Germany.
(15) Kinetics, and the effect of competitors as well as of specific inhibitors show this enzyme to be identical to the well-known kidney gamma-glutamyltranspeptidase ((gamma-glutamyl)-peptide:amino-acid gamma-glutamyltransferase, EC 2.3.2.2).
(16) In order to investigate the relationship between the origin-binding domain and the second region, we performed origin-specific DNA binding assays with increasing amounts of calf thymus DNA as competitor.
(17) Roberts said: "We are recognised as a stand out competitor within the IPO queue.
(18) If we can get the Bank of England to fund the banking system, why don’t we get them to build us a proper broadband system as modern and efficient as you’ve got in many of our competitors,” Livingstone said.
(19) In September it set up it's own union – the Social Workers Union – but denied it was a competitor to other trade unions.
(20) Studies in several types of animal models, especially cholesterol-fed rabbits, have shown that calcium competitors, calcium chelators, anticalcifying agents, and calcium channel blockers can reduce the accumulation of atherogenic lesion components and thus apparently decrease the progression of lesions.