(1) This death is also dependent on the presence of chloride and is prevented with the non-selective EAA antagonist, kynurenic acid, but is not prevented by QA.
(2) Microionophoretically applied excitatory amino acids induced firing of extracellularly recorded single units in a tissue slice preparation of the mouse cochlear nucleus, and the similarly applied antagonist 2-amino-5-phosphonovalerate (2APV) was demonstrated to be a selective N-methyl-D-aspartate (NMDA) receptor antagonist.
(3) Meanwhile the efficiency of muscarinic antagonists in inhibition of tremor reaction induced by arecoline administration is associated with interaction between the drugs and the M2-subtype.
(4) The anticonvulsant properties of the endogenous excitatory amino acid antagonist, kynurenic acid (KYA), were studied in prepubescent and adult rats using the amygdaloid kindling model of epilepsy.
(5) A novel bicyclic prostaglandin analogue, (1S)-[1 alpha,2 alpha(Z),3 alpha,4 alpha]-7-[3-[(hexylthio)methyl]-7- oxabicyclo [2.2.1]hept-2-yl]-5-heptenoic acid ((-)-10), and its cogeners were found to be potent antagonists at the TxA2 receptor.
(6) This difference was abolished by exposure of the slices to propranolol, a beta-adrenergic receptor antagonist.
(7) The TxA2 antagonistic effects of KW-3635 were compared with that of daltroban in PRP from various animals species.
(8) In experiments performed to determine whether PtdIns(4,5)P2 hydrolysis induced by TRH may have been caused by the elevation of [Ca2+]i, the following results were obtained: the effect of TRH to decrease the level of PtdIns(4,5)P2 was not reproduced by the calcium ionophore A23187 or by membrane depolarization with 50 mM K+; the calcium antagonist TMB-8 did not inhibit the TRH-induced decrease in PtdIns(4,5)P2; and, most importantly, inhibition by EGTA of the elevation of [Ca2+]i did not inhibit the TRH-induced decrease in PtdIns(4,5)P2.
(9) Similarly, 50 microM D-600, a Ca+2 channel antagonist, significantly (P less than 0.01) reduced basal and 5-HETE-induced PRL release.
(10) Selective removal of endothelium had no effect on BK-induced contraction or the action of the antagonists.
(11) The second experiments entailed use of the nonspecific opiate antagonist, naloxone, as well as the specific delta antagonist, ICI 154,129, against seizures induced by icv-administered morphine, morphiceptin, DADL, or DSLET.
(12) These antagonists reverse NMDA-mediated long term influence in these brain areas.
(13) This novel mechanism of receptor regulation, named transmodulation, should be distinguished from the reduction in total receptor number caused by the homologous ligand (downregulation) and from the change in affinity produced by the binding of agonists or antagonists to the same receptor site.
(14) Furthermore, the ability of a vasopressin antagonist to lower arterial pressure in NTS hypertensive rats was markedly attenuated by clonidine treatment.
(15) All of the serotonergic antagonists studied had additional effects on the response of the coronary artery to electrical stimulation or to norepinephrine.
(16) Their receptive fields comprise a temporally and spatially linear mechanism (center plus antagonistic surround) that responds to relatively low spatial frequency stimuli, and a temporally nonlinear mechanism, coextensive with the linear mechanism, that--though broad in extent--responds best to high spatial-frequency stimuli.
(17) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(18) Addition in the cultures of 4-deoxypyridoxine, a potent antagonist of vitamin B6 coenzymes, concurrently with the mitogen, inhibits the induction of serine hydroxymethyltransferase.
(19) These results suggest that prevention of xenograft rejection using PAF-antagonist in association with other methods should be further investigated.
(20) The high concentrations of gonadotropins present in immature female rats by the end of the second week of life were suppressed by treatment with an antagonist against luteinizing hormone-releasing hormone (LHRH-A; Org.
Hostile
Definition:
(a.) Belonging or appropriate to an enemy; showing the disposition of an enemy; showing ill will and malevolence, or a desire to thwart and injure; occupied by an enemy or enemies; inimical; unfriendly; as, a hostile force; hostile intentions; a hostile country; hostile to a sudden change.
(n.) An enemy; esp., an American Indian in arms against the whites; -- commonly in the plural.
Example Sentences:
(1) Some of their most cherished objectives, such as parliamentary reform, have been left as roadkill by the juggernauts of Tory and Labour hostility.
(2) Mars is a much more hostile environment than people realise, they point out.
(3) It's an attractive idea, and yet pride in Europe appears to be giving way to populism and hostility within the union.
(4) But even among the most hostile voters, only a third put Europe among the most crucial issues facing the country.
(5) Afghan officials in the past have expressed fears that soldiers sent to Pakistan could be recruited as spies or that their careers would be stunted by the deep hostility that Afghans harbour towards Pakistan.
(6) Michael Holroyd, in his biography of George Bernard Shaw , gives an illuminating example of myopic hostility to Russia by the right even when we desperately needed allies.
(7) Overall, these results suggest that future research should investigate variables in addition to hostility in regard to risk for and protection from CHD.
(8) As important, if not more so, as his ambition to make exams tougher is his hostility towards other measures of ability, such as course work and controlled assessments.
(9) Journalists are being told to speak to public affairs office, but the public affairs office doesn't call them back or is hostile."
(10) Green groups were hostile or reacted cautiously to the report.
(11) To assess physiological and psychological states accompanying anabolic-androgenic steroid use, male weight lifters 1) were interviewed regarding their physical training and the patterns and effects of any drug use; 2) completed a written physical and medical history questionnaire, a Profile of Mood States questionnaire, and the Buss-Durkee Hostility Inventory; and 3) were physically examined, including a blood sample and urinalysis.
(12) The sugar tax was greeted with hostility by the industry and Wright argues that the levy, introduced by the chancellor in the budget , will be undermined by flawed analysis of its impact.
(13) Murdoch had one on his, of course, but because he was facing hostile interrogation he looked (unfairly) as if he were wearing it in self-protection as a symbol of his own virtue.
(14) Tory MEP Nirj Deva was one of several deputies to subject Mr Nielson to hostile questioning.
(15) Yet, the long list of allegations included no statement from Kenneth Bae, other than claims that he confessed and didn't want an attorney present during his sentencing last week for what Pyongyang called hostile acts against the state.
(16) We are effectively now placed in co-sovereignty with a hostile power.
(17) The inquiry’s chairman, Sir Thayne Forbes, a former high court judge, concluded in 2014 that the most serious claims were “deliberate lies, reckless speculation and ingrained hostility”.
(18) Faced with ever growing hostility to the EU, and to immigration, Clegg has decided to present the Liberal Democrats unambiguously as the party of "in" and of openness.
(19) The aim of this study was to determine how individual differences in cynical hostility and defensiveness interacted with situational demands to affect cardiovascular responses in a natural setting.
(20) The Saudis and other Gulf states still support rebel fighting formations – as much because of inertia and hostility to Iran as anything else – but western backing is on a downward trajectory as concerns mount about the risks of blowback from al-Qaida-linked groups.