(v. t.) To contend with; to oppose actively; to counteract.
(v. i.) To act in opposition.
Example Sentences:
(1) Intrathecal injection of zopiclone potentiated morphine antinociception, while the intracerebroventricular injection of zopiclone failed to enhance morphine antinociception and the intracerebroventricular injection of flumazepil to antagonize the intraperitoneal-zopiclone-induced increase in morphine antinociception.
(2) of PLA2 caused marked degranulation of mast cells in the rat mesentery which was facilitated by addition of calcium ion (10 mM) but antagonized by pretreating with three antiinflammatory agents.
(3) [Ca2+]i exhibited a sigmoidal dependence on [Na+]o. Mg2+, a competitive inhibitor of Na2+-Ca2+ antiport in these cells, antagonized the increase in [Ca2+]i produced by lowering [Na+]o.
(4) Increases in extracellular calcium antagonized the negative inotropic effect.
(5) In K+-depolarized basilar arteries, ifenprodil competitively antagonized the response to Ca2+, and this was enhanced by pre-incubation in calcium hopantenate.
(6) During the postovulatory phase, endogenous progesterone and the production of metabolites antagonized this effect.
(7) An antagonism is unlikely when ciprofloxacin is combined with one of the beta-lactams studied or with tobramycin.
(8) Co-application of CGS 9896, a benzodiazepine receptor antagonist, did not antagonize the guanidino compound-induced inhibition of GABA responses.
(9) Aortic rings from the rabbit were similarly potently antagonized by the protein kinase C inhibitors, however, K(+)-induced contractions were also equally sensitive to these agents in both rat and rabbit tissues.
(10) The biphasic response to (-)-(S)-Bay K 8644 and (+)-(S)-202-791 suggests that the properties of Ca++ channel activation and antagonism may reside within a single 1,4-dihydropyridine molecule.
(11) We have investigated the bacterial antagonism exerted in oral secretion by alpha-hemolytic streptococci against S. aureus and S. epidermidis.
(12) The marine natural product lophotoxin has produced a non-reversible antagonism of parasympathetic and sympathetic functions that are known to be mediated by C6 sub-type nicotinic receptors.
(13) Strains showing occasional antagonism at a particular proportion of concentrations of the test combination, were found to only be indifferent when the mean index of the fractional inhibition concentration of all checkerboard combinations was calculated.
(14) The omission of glucose induced a marked increase in the efflux of [3H]GABA, which was antagonized by TTX (1 microM), but not by MK 801 (1 microM) or DNQX (100 microM).
(15) The hyperthermia in rabbits caused by the serotonergic stimulants cited above is also antagonized by pretreatment with MS.
(16) The neuroleptic agents haloperidol, fluphenazine, domperidone, sulpiride and tiapride also antagonized emesis induced by cisplatin but only a proportion of the animals were completely protected and diazepam and prednisolone only reduced the intensity of the response.
(17) These results suggest that formoterol modifies allergen-induced airway responses through functional antagonism rather than the inhibition of inflammatory cell infiltration.
(18) Depolarizations induced by acetyl-Arg6-septide, a NK1-receptor selective agonist, were also antagonized by spantide with a pA2 of 6.5.
(19) 5-Hydroxytryptamine contracted the musculature from all parts of the respiratory tract-an effect which was specifically antagonized by both methysergide and atropine.4.
(20) K showed little activity against LTC4 but could antagonize more selectively H- and ACh-mediated effects.
Excruciate
Definition:
(a.) Excruciated; tortured.
(v. t.) To inflict agonizing pain upon; to torture; to torment greatly; to rack; as, to excruciate the heart or the body.
Example Sentences:
(1) A 33-year old woman was admitted with high fever and excruciating pain in the lower right abdomen that had lasted on and off for months.
(2) However, after her diagnosis, it became my occupation to know everything about her ailment because I was her caregiver during her excruciating decline.
(3) It is an excruciating fly-on-the-wall witness to Allison's vainglory, Swales's self-regard for his own leadership qualities and the poor young players' overpromoted helplessness.
(4) Another great feature of the panda, at least as far as Chairman Mao Zedong and his followers were concerned, was that the rest of the world, particularly the west, had become obsessed by its excruciatingly cute looks and behaviour.
(5) Far from being relaxed, I feel excruciatingly uncomfortable and begin to wonder if my jaw is malfunctioning.
(6) (Mail Online goes into excruciating detail on the methods Williams used, but does so in the body copy of an article.)
(7) The film charts in excruciating detail the collapse of a political career and, ultimately, of a marriage.
(8) One more win now, one more good performance against the sort of team they have swatted aside all season, and the long, often excruciating wait will be over: City will be champions.
(9) In the very act of describing sex as an incidental, you create an excruciating sex scene.
(10) Our most excruciating agony is of not being noticed in the world.
(11) An effective piece of propaganda at the time, it makes pretty excruciating viewing now that we know what happens next.
(12) With Foord having lost his entire leg, including his hip, even getting him out of bed and sitting in his wheelchair was excruciating.
(13) "The timing is excruciating for whomever wins the next election."
(14) A women who has been infibulated suffers great difficulty and pain during sexual intercourse, which can be excruciating if a neuroma has formed at the point of section of the dorsal nerve of the clitoris.
(15) During the first postoperative week little pain was experienced by 60% of the patients, considerable pain by 35% and excruciating pain by 5% of the patients being interviewed.
(16) Yet if I tell you I’ve had a chronic illness since early childhood that is known for excruciating pain, for causing immobility and secondary – sometimes life-threatening – conditions, does that change your view of my suicide attempt?
(17) As well as being a pallid substitute for actual creativity – a device for making grey business wonks mistake themselves for David Bowie at his experimental peak – these books are the direct suit-and-tie office-dick equivalent of those embarrassing motivational self-help tomes that prey on the insecure, promising to turn their life around before dissolving into a blancmange of "strategies" and "systems" and above all excruciating metaphors.
(18) Perhaps it signifies an end to those media appearances in which politicians share the contents of their iPods or talk, excruciatingly, about their love of whatever indie band their aide has decided they should like, in an attempt to persuade voters they're young and fun.
(19) The real importance of Thomas Piketty's blockbuster, Capital in the 21st Century , is that it demonstrates, in excruciating detail (and this remains true despite some predictable petty squabbling) that, in the case of at least one core equation, the numbers simply don't add up .
(20) The disease is often serious and can cause excruciating pain in the joints and other parts of the body.