(1) It was concluded that metoclopramide and dexamethasone showed an excellent antiemetic effect on acute drug-induced emesis, as well as on delayed emesis, induced by cisplatin.
(2) Alizapride (ALZ) is a new benzamide derivative with promising antiemetic activity.
(3) Overall, antiemetic protection was appreciable: complete emetic protection (no emetic episodes) was observed in 71 and 66% of patients receiving MPN 375 and 120 mg, respectively.
(4) This paper identifies important factors in selecting antiemetic therapy, particularly the emetogenic potential of the chemotherapy and the fact that antiemetic drugs have differing sites of action.
(5) Only 2 patients (8%) did not experience an improvement of their symptoms in any of the treatment cycles as measured by a self-conducted grading of nausea and by the frequency of vomiting in comparison to a previous treatment cycle under conventional antiemetic therapy.
(6) Gastrointestinal disturbances--vomiting and diarrhea--were also common, despite a low initial dose of PGE2 and premedication with antiemetic and antidiarrheal agents.
(7) The antiemetic effect and the therapeutic effect of domperidone on complaints by gastrointestinal retention was the result of the influence on gastrointestinal motility, which is similar to that of metoclopramide.
(8) Further, a metabolite of haloperidol seems to be responsible for its effective antiemetic action.
(9) Strategies to support chemotherapy dose intensification include BMT, use of CSFs and antiemetic drug combinations.
(10) The maintenance of the antiemetic efficacy of ondansetron was further studied in 28 patients (13 A, 15 B) in respectively 36 and 48 retreatment courses.
(11) It possesses at the same time potent gastro-intestinal prokinetic and central antiemetic properties, demonstrated on the one hand by the gastro-duodenal transit of barium meal in rats, and on the other hand by apomorphine-induced vomiting in dogs.
(12) Both findings demonstrate that bismuth subsalicylate can provide antiemetic action and that the decreases in the occurrence of emesis in humans and dogs parallels the decrease in nausea found in humans and the nausea suspected to occur prior to emesis in dogs.
(13) A randomized, double blind crossover trial compared the antiemetic effects of alizapride, a benzamide, and prochlorperazine, a phenothiazine, both administered intravenously to 32 patients treated with chemotherapy combinations containing cisplatin.
(14) The results indicate that 5-HT3 recognition sites are present within the area postrema and may afford an antiemetic site of action for zacopride and other 5-HT3 receptor antagonists.
(15) In early clinical trials alizapride showed a better antiemetic activity with fewer side effects than metoclopramide.
(16) The most frequent side effect was vomiting, registered in all patients despite antiemetic treatment.
(17) There were very few and slight adverse effects secondary to antiemetic drugs: Sedation happened in 25% of chemotherapic cycles and hypotension without clinical repercussion in 15%.
(18) The basis of the antiemetic action of other drugs such as dexamethasone and the cannabinoids is still obscure.
(19) Less recognized is that extrapyramidal symptoms are also associated with certain non-antipsychotic agents, including some antidepressants, lithium, various anticonvulsants, antiemetics and, rarely, oral-contraceptive agents.
(20) Diphenhydramine was used because of its possible antiemetic properties and its ability to control acute dystonic reactions.
Nausea
Definition:
(n.) Seasickness; hence, any similar sickness of the stomach accompanied with a propensity to vomit; qualm; squeamishness of the stomach; loathing.
Example Sentences:
(1) She had three attacks of severe migrainous headache accompanied with nausea and vomiting within three weeks.
(2) Most survivors reported a range of problems that they attributed to having had cancer: 35%, proven or perceived infertility; 24%, sexual problems; 31%, health and life insurance problems; 26%, a negative socioeconomic effect; and 51%, conditioned nausea, associated with visual or olfactory reminders of chemotherapy.
(3) Among the major symptoms were gastrointestinal disorders such as subjective and objective anorexia, nausea and vomiting.
(4) A 68-year-old male was hospitalized because of headache, nausea, and disturbance of consciousness.
(5) Inner Ear Decompression Sickness (IEDCS)--manifested by tinnitus, vertigo, nausea, vomiting, and hearing loss--is usually associated with deep air or mixed gas dives, and accompanied by other CNS symptoms of decompression sickness (DCS).
(6) Frequency of symptoms like dizziness, headache, lachrymation, burning sensation in eyes, nausea and anorexia, etc, were much more in the exposed workers.
(7) Mean run time and total ST time were faster with CE (by 1.4 and 1.2 min) although not significantly different (P less than 0.06 and P less than 0.10) from P. Subjects reported no significant difference in nausea, fullness, or stomach upset with CE compared to P. General physiological responses were similar for each drink during 2 h of multi-modal exercise in the heat; however, blood glucose, carbohydrate utilization, and exercise intensity at the end of a ST may be increased with CE fluid replacement.
(8) Other toxicity was mild and included nausea and vomiting, diarrhea, mucositis, hepatic dysfunction, and cardiac arrhythmias.
(9) The time to first episode of moderate to severe nausea was significantly longer in the granisetron group (P = 0.03).
(10) Symptoms include nausea, vomiting, dizziness, and prostration.
(11) Adverse effects included nausea, light-headedness, dyskinesias, and hallucinations, all of which abated after the Sinemet dose was reduced.
(12) Significantly more slow acetylators stopped treatment because of nausea or vomiting, or both, but serious toxicity was not confined to either group.
(13) Postoperative nausea and vomiting have been associated with the use of intravenous narcotics, and nitrous oxide may worsen the emetic effects of narcotics.
(14) Side-effects (pruritus, nausea, vomiting, drowsiness) were also noted.
(15) Fourteen of 15 patients had a reduction in nausea and vomiting on THC as compared to placebo.
(16) Nausea, generally mild and of short duration, increased from start (30%) to end of radiotherapy (54%).
(17) A bolus of 0.1 mg.kg-1 followed by a continuous infusion of 1 mg.kg-1.hr-1 was effective in both prevention and treatment of nausea and vomiting.
(18) Significant toxicities included drug-induced hepatitis along with moderate nausea and vomiting.
(19) No subject reported side effects of oxitropium, as compared to three subjects reporting nausea, vomiting and tremors after theophylline.
(20) Nausea and heartburn occurred in 3 cases only and were controlled by reducing the dosage.