(a.) Pertaining to the antipodes; situated on the opposite side of the globe.
(a.) Diametrically opposite.
Example Sentences:
(1) R-(+)-Nicotine is a substrate Km = 1.42 X 10(-5)M for an SAM-dependent guinea pig lung aromatic azaheterocycle N-methyltransferase, whereas S-(-)-nicotine acts as a competitive inhibitor (Ki = 6.25 X 10(-5)M) of the N-methylation of its antipode.
(2) The 5-HT depleting potency of (+)-MDMA was significantly greater than that of its (-)-antipode at 3 hr in PB pretreated, but not in SKF-525A pretreated animals.
(3) Potential in the Antipodes for production of unique and abundant fishery products is immense for both local and export markets.
(4) In general antipodals have maximum accumulation of physiologically active substances and intense activity of different enzymes.
(5) Since the transformation goes from the inactive to the pharmacologically active form, the (R)-enantiomer can be considered as a prodrug of its (S)-antipode.
(6) The determination of the enantiomeric composition of the excreted 2-phenylpropionic acid after a single oral dose indicated that the (R)-(-)-enantiomer given as such or in the racemate was inverted to its antipode, which strongly suggests that (S)-(+)-2-phenylpropionic acid is responsible for the inductive effects observed.
(7) The area under the concentration versus time curve values for the two enantiomers were approximately 10% higher for the (R)-antipode because of a slightly slower elimination of this compound.
(8) Both optical antipodes of the pivotal epoxy alcohol intermediate were prepared in 95% enantiomeric excess by the Sharpless epoxidation of a (Z)-allylic alcohol.
(9) Chiral analysis of the human renal epoxyeicosatrienoic acids shows the formation of 8,9-, 11,12- and 14,15-epoxyeicosatrienoic acids in a 1:1, 4:1 and 2:1 ratio of antipodes, respectively.
(10) The limit of determination for the L-antipode is ca.
(11) However, this stereoselectivity of action is not manifest in vivo, due to the thus-far-unique unidirectional metabolic inversion of the chiral centre from the inactive R(-)-isomers to the S(+)-antipodes.
(12) The summation of the results fully defines the overall stereochemistry of the coupled isomerization and cyclization of geranyl pyrophosphate to the antipodal pinenes.
(13) The Bernburg physician and pharmaceutist Bucholz became there for many years his consultee for questions of natural sciences; Gren, who also came from Bernburg, became the antipode in the dispute about problems of optics.
(14) 8a showed potent antifungal activity, while its antipode (+)-cis-2-ACPC (8b) had no activity.
(15) A novel approach to the optical resolution of racemic enones has been introduced by using the binding properties of the transport protein albumin, which chemically binds preferentially one antipode of some alpha, beta-unsaturated cyclic enones in a reversible manner.
(16) The model successfully: (1) explained the relative activity or inactivity of compounds such as cis- and trans-1-methyl-5-hydroxyl ATN derivatives and the corresponding cis- and trans-octohydrobenzo[f]quinolines; (2) predicted the more potent antipode of 2-aminoindan dopaminergic agonists; and (3) explained the structure--activity peculiarities of 3-(3-hydroxyphenyl)-N-alkylpiperidines in which the potency is increased for (3S)-isomers and decreased for (3R)-isomers when the N-alkyl group is greater than propyl.
(17) The three antipodal wave forms were displayed as a single 3-D Lissajous trajectory which contained four apices, corresponding to P40 (apex A), N70 (apex B), P100 (apex C) and N125 (apex D).
(18) Patch currents recorded at the soma cap, antipodal to the origin of the axon, and whole-cell currents were recorded simultaneously and normalized to membrane capacitance.
(19) Structures for such chirally symmetric organisms are outlined, as is the gradual decoupling of their integrated antipodal metabolisms upon an evolutionary progression from meso organism to racemic organism to racemate of organisms.
(20) A marked antipodal potency ratio was observed in strains TA100 and TA1535 when racemic and L-azidoalanine were compared.
Antithetic
Definition:
(a.) Alt. of Antithetical
Example Sentences:
(1) Products which have antithetical functions such as FSH and inhibin or cystatin and cathepsin L are found in different modes.
(2) We describe a 46-year-old white woman with typical clinical features of posttransfusion purpura (PTP) whose serum held a platelet-specific alloantibody reactive with an antigen antithetical to Baka, i.e.
(3) This dialectic is defined as the synthesis of the antithetical strategies of Dealing With It and Keeping It in Its Place in which people are able to transcend each strategy and sustain hope.
(4) Niemeyer’s buildings are characterised by their levity, playfulness, and curves, which are all antithetical to brutalism.
(5) Further understanding of the interactions of the immune system with exocrine products of the male reproductive system may contribute to improvements in reproductive health and to an understanding of the antithetical aspects of the immune response represented by such biological phenomena as insemination, pregnancy and malignancy.
(6) These data provide further support for the concept that CRH not only triggers the pituitary-adrenal antiinflammatory cascade, but also functions as an antithetically active local mediator of acute and chronic inflammatory arthritis.
(7) Indefinite detention – holding detainees for what is now decades with no trial or even charges of any kind on the horizon – is about as antithetical to American values and the constitution as it gets.
(8) Marketing techniques that are used in this buyers' market allow no active patient participation and are therefore antithetical to the tenets of psychotherapy.
(9) Photograph: FutureDairy I had imagined the world’s first robotic rotary milking dairy at Camden to be a clinical, mechanical affair, antithetical to the steamy breath, soft underbellies and leisurely bovine sensibilities of the cattle it deals with.
(10) Evidence is presented for the antithetical relationship of In-a with a previously unreported high frequency antigen, Salis.
(11) That shows that TAM have antithetic activities in the life of neoplasia.
(12) A therapeutic emphasis on "inner spirit" is a very long way from the radical feminism Ensler grew up with in the 1960s and 70s, and many activists of that era would consider talk of "doing work on ourselves" fundamentally antithetical to their political project.
(13) Some argue that the Malibu model is actually antithetical to sobriety.
(14) "However, to label people who hold views different from the government of the country and to label those who criticise the Iranian government as enemies, is unproductive and antithetical to the international treaties to which Iran is a party."
(15) The findings suggest that the clinical features are antithetical to the trisomy 9p syndrome.
(16) Navigating between their religious and cultural identities these young women – who don’t believe consumerism or fashion is antithetical to their religious beliefs – are driving up the value of the modest fashion industry, and the Muslim pound for that matter.
(17) Thus on P815 target cells GL183 MAb has an effect antithetical to that of other stimuli including PHA, anti-CD2 or anti-CD16 MAbs.
(18) However, careful examination of the report reveals that the data support conclusions antithetical to those at which the author arrived.
(19) the overcoming of suffering through suffering, is contrasted to the antithetical behaviour, i.e.
(20) The use of suggestion as a technique is viewed as antithetical to the aims of exploratory psychoanalytic therapy and presents serious problems in the resolution of transference issues when it is used either inadvertently or as a parameter of the therapy.