(a.) Pertaining to the antipodes; situated on the opposite side of the globe.
(a.) Diametrically opposite.
Example Sentences:
(1) R-(+)-Nicotine is a substrate Km = 1.42 X 10(-5)M for an SAM-dependent guinea pig lung aromatic azaheterocycle N-methyltransferase, whereas S-(-)-nicotine acts as a competitive inhibitor (Ki = 6.25 X 10(-5)M) of the N-methylation of its antipode.
(2) The 5-HT depleting potency of (+)-MDMA was significantly greater than that of its (-)-antipode at 3 hr in PB pretreated, but not in SKF-525A pretreated animals.
(3) Potential in the Antipodes for production of unique and abundant fishery products is immense for both local and export markets.
(4) In general antipodals have maximum accumulation of physiologically active substances and intense activity of different enzymes.
(5) Since the transformation goes from the inactive to the pharmacologically active form, the (R)-enantiomer can be considered as a prodrug of its (S)-antipode.
(6) The determination of the enantiomeric composition of the excreted 2-phenylpropionic acid after a single oral dose indicated that the (R)-(-)-enantiomer given as such or in the racemate was inverted to its antipode, which strongly suggests that (S)-(+)-2-phenylpropionic acid is responsible for the inductive effects observed.
(7) The area under the concentration versus time curve values for the two enantiomers were approximately 10% higher for the (R)-antipode because of a slightly slower elimination of this compound.
(8) Both optical antipodes of the pivotal epoxy alcohol intermediate were prepared in 95% enantiomeric excess by the Sharpless epoxidation of a (Z)-allylic alcohol.
(9) Chiral analysis of the human renal epoxyeicosatrienoic acids shows the formation of 8,9-, 11,12- and 14,15-epoxyeicosatrienoic acids in a 1:1, 4:1 and 2:1 ratio of antipodes, respectively.
(10) The limit of determination for the L-antipode is ca.
(11) However, this stereoselectivity of action is not manifest in vivo, due to the thus-far-unique unidirectional metabolic inversion of the chiral centre from the inactive R(-)-isomers to the S(+)-antipodes.
(12) The summation of the results fully defines the overall stereochemistry of the coupled isomerization and cyclization of geranyl pyrophosphate to the antipodal pinenes.
(13) The Bernburg physician and pharmaceutist Bucholz became there for many years his consultee for questions of natural sciences; Gren, who also came from Bernburg, became the antipode in the dispute about problems of optics.
(14) 8a showed potent antifungal activity, while its antipode (+)-cis-2-ACPC (8b) had no activity.
(15) A novel approach to the optical resolution of racemic enones has been introduced by using the binding properties of the transport protein albumin, which chemically binds preferentially one antipode of some alpha, beta-unsaturated cyclic enones in a reversible manner.
(16) The model successfully: (1) explained the relative activity or inactivity of compounds such as cis- and trans-1-methyl-5-hydroxyl ATN derivatives and the corresponding cis- and trans-octohydrobenzo[f]quinolines; (2) predicted the more potent antipode of 2-aminoindan dopaminergic agonists; and (3) explained the structure--activity peculiarities of 3-(3-hydroxyphenyl)-N-alkylpiperidines in which the potency is increased for (3S)-isomers and decreased for (3R)-isomers when the N-alkyl group is greater than propyl.
(17) The three antipodal wave forms were displayed as a single 3-D Lissajous trajectory which contained four apices, corresponding to P40 (apex A), N70 (apex B), P100 (apex C) and N125 (apex D).
(18) Patch currents recorded at the soma cap, antipodal to the origin of the axon, and whole-cell currents were recorded simultaneously and normalized to membrane capacitance.
(19) Structures for such chirally symmetric organisms are outlined, as is the gradual decoupling of their integrated antipodal metabolisms upon an evolutionary progression from meso organism to racemic organism to racemate of organisms.
(20) A marked antipodal potency ratio was observed in strains TA100 and TA1535 when racemic and L-azidoalanine were compared.
Pole
Definition:
(n.) A native or inhabitant of Poland; a Polander.
(n.) A long, slender piece of wood; a tall, slender piece of timber; the stem of a small tree whose branches have been removed; as, specifically: (a) A carriage pole, a wooden bar extending from the front axle of a carriage between the wheel horses, by which the carriage is guided and held back. (b) A flag pole, a pole on which a flag is supported. (c) A Maypole. See Maypole. (d) A barber's pole, a pole painted in stripes, used as a sign by barbers and hairdressers. (e) A pole on which climbing beans, hops, or other vines, are trained.
(n.) A measuring stick; also, a measure of length equal to 5/ yards, or a square measure equal to 30/ square yards; a rod; a perch.
(v. t.) To furnish with poles for support; as, to pole beans or hops.
(v. t.) To convey on poles; as, to pole hay into a barn.
(v. t.) To impel by a pole or poles, as a boat.
(v. t.) To stir, as molten glass, with a pole.
(n.) Either extremity of an axis of a sphere; especially, one of the extremities of the earth's axis; as, the north pole.
(n.) A point upon the surface of a sphere equally distant from every part of the circumference of a great circle; or the point in which a diameter of the sphere perpendicular to the plane of such circle meets the surface. Such a point is called the pole of that circle; as, the pole of the horizon; the pole of the ecliptic; the pole of a given meridian.
(n.) One of the opposite or contrasted parts or directions in which a polar force is manifested; a point of maximum intensity of a force which has two such points, or which has polarity; as, the poles of a magnet; the north pole of a needle.
(n.) The firmament; the sky.
(n.) See Polarity, and Polar, n.
Example Sentences:
(1) Two small populations of GLY + neurons were observed outside of the named nuclei of the SOC; one was located dorsal to the LSO, near its dorsal hilus, and the other was identified near the medial pole of the LSO.
(2) In 22 cases (63%), retinal detachment was at least partially flattened in the area of the posterior pole of the eye.
(3) Delineation of the presence and anatomy of an obstructed, nonfunctioning upper-pole duplex system often requires multiple imaging techniques.
(4) David Blunkett, not Straw, was the home secretary at the time the decision was taken to allow Poles and others immediate access to the British labour market.
(5) PYY-containing secretory granules were primarily found in the basal pole of open-type endocrine cells.
(6) Were he from Iceland, or from the north pole, then I would say he still had his ski boots on.
(7) A 40 year old female presented with secondary glaucoma and loss of vision due to anterior pole metastasis of breast carcinoma.
(8) A modification of a previously described curved ruler, the current model has a hinge for greater ease of maneuverability and a "T" piece on one end to facilitate measurement and marking of both poles of the muscle without repositioning the ruler.
(9) Two of them, the radiocapitate and deep radioscapholunate, insert on the scaphoid, whereas the collateral ligament courses to the distal pole of the scaphoid.
(10) Thus, the present observations provide histochemical evidence indicating an exclusive localization of calcium in mitochondria and tubulovesicular structures of the secretory ameloblast, and support their contributions to the translocation of calcium from the proximal to the distal pole of the cytoplasm.
(11) His balancing pole swayed uncontrollably, nearly tapping the sides of his feet.
(12) The retinal findings are quite similar to those found in diabetic retinopathy, except for unilaterality corresponding to the more obstructed artery and early onset in the retinal midzone rather than the posterior pole.
(13) Less marked lesions were however observed in distal tubules, particularly large vacuoles were present at the apical poles of the tubule cells, the sites of kallikrein secretion.
(14) The testicular vein--midway between the internal inguinal ring and the lower pole of the kidney--divides into the medial and lateral branch to form a delta.
(15) Probably there is a continuity of this system throughout the entire vascular pole including (1) all granulated cells, (2) all lacis cells, (3) the mesangium cells and (4) the adjacent smooth muscle cells of the vas afferens and vas efferens.
(16) In all of the old rats, but not in any of the young ones, symmetric high voltage activity was observed in the frontal pole of the cortex.
(17) Later, these vacuoles were divided into numerous vesicular spiral formation-centers, producing micronemes at the apical pole of young merozoites.
(18) Therefore, this nonrandom segregation to opposite poles can occur by mechanisms that do not involve DNA sequence homology.
(19) The intranuclear spindle of yeast has an electron-opaque body at each pole.
(20) All of these AChE positive fibers appeared to be related to the medial portions of the dorsal hippocampus from its septal pole to the dorsal psalterium.