(n.) One of the antipodes; anything exactly opposite.
Example Sentences:
(1) R-(+)-Nicotine is a substrate Km = 1.42 X 10(-5)M for an SAM-dependent guinea pig lung aromatic azaheterocycle N-methyltransferase, whereas S-(-)-nicotine acts as a competitive inhibitor (Ki = 6.25 X 10(-5)M) of the N-methylation of its antipode.
(2) The 5-HT depleting potency of (+)-MDMA was significantly greater than that of its (-)-antipode at 3 hr in PB pretreated, but not in SKF-525A pretreated animals.
(3) Potential in the Antipodes for production of unique and abundant fishery products is immense for both local and export markets.
(4) In general antipodals have maximum accumulation of physiologically active substances and intense activity of different enzymes.
(5) Since the transformation goes from the inactive to the pharmacologically active form, the (R)-enantiomer can be considered as a prodrug of its (S)-antipode.
(6) The determination of the enantiomeric composition of the excreted 2-phenylpropionic acid after a single oral dose indicated that the (R)-(-)-enantiomer given as such or in the racemate was inverted to its antipode, which strongly suggests that (S)-(+)-2-phenylpropionic acid is responsible for the inductive effects observed.
(7) The area under the concentration versus time curve values for the two enantiomers were approximately 10% higher for the (R)-antipode because of a slightly slower elimination of this compound.
(8) Both optical antipodes of the pivotal epoxy alcohol intermediate were prepared in 95% enantiomeric excess by the Sharpless epoxidation of a (Z)-allylic alcohol.
(9) Chiral analysis of the human renal epoxyeicosatrienoic acids shows the formation of 8,9-, 11,12- and 14,15-epoxyeicosatrienoic acids in a 1:1, 4:1 and 2:1 ratio of antipodes, respectively.
(10) The limit of determination for the L-antipode is ca.
(11) However, this stereoselectivity of action is not manifest in vivo, due to the thus-far-unique unidirectional metabolic inversion of the chiral centre from the inactive R(-)-isomers to the S(+)-antipodes.
(12) The summation of the results fully defines the overall stereochemistry of the coupled isomerization and cyclization of geranyl pyrophosphate to the antipodal pinenes.
(13) The Bernburg physician and pharmaceutist Bucholz became there for many years his consultee for questions of natural sciences; Gren, who also came from Bernburg, became the antipode in the dispute about problems of optics.
(14) 8a showed potent antifungal activity, while its antipode (+)-cis-2-ACPC (8b) had no activity.
(15) A novel approach to the optical resolution of racemic enones has been introduced by using the binding properties of the transport protein albumin, which chemically binds preferentially one antipode of some alpha, beta-unsaturated cyclic enones in a reversible manner.
(16) The model successfully: (1) explained the relative activity or inactivity of compounds such as cis- and trans-1-methyl-5-hydroxyl ATN derivatives and the corresponding cis- and trans-octohydrobenzo[f]quinolines; (2) predicted the more potent antipode of 2-aminoindan dopaminergic agonists; and (3) explained the structure--activity peculiarities of 3-(3-hydroxyphenyl)-N-alkylpiperidines in which the potency is increased for (3S)-isomers and decreased for (3R)-isomers when the N-alkyl group is greater than propyl.
(17) The three antipodal wave forms were displayed as a single 3-D Lissajous trajectory which contained four apices, corresponding to P40 (apex A), N70 (apex B), P100 (apex C) and N125 (apex D).
(18) Patch currents recorded at the soma cap, antipodal to the origin of the axon, and whole-cell currents were recorded simultaneously and normalized to membrane capacitance.
(19) Structures for such chirally symmetric organisms are outlined, as is the gradual decoupling of their integrated antipodal metabolisms upon an evolutionary progression from meso organism to racemic organism to racemate of organisms.
(20) A marked antipodal potency ratio was observed in strains TA100 and TA1535 when racemic and L-azidoalanine were compared.
Juxtapose
Definition:
(v. t.) To place in juxtaposition.
Example Sentences:
(1) It may be that the low severity of the disease in India, juxtaposed against the high mortality rates in parts of Africa, may be due to the relative prevalence of marasmic and kwashiorkor types of malnutrition in these particular geographic areas.
(2) Antibody genes are assembled from a series of germ-line gene segments that are juxtaposed during the maturation of B lymphocytes.
(3) A recent systematic investigation of domain structures consisting of juxtaposed icosahedral columns is also presented.
(4) Often juxtaposing sets of striations are not in correct register with respect to one another.
(5) By three hours postcoitus, the region beneath the basement lamina of the vaginal epithelium is crowded with numerous juxtaposed leukocytes.
(6) The phosphoribulokinase reaction involves a single in-line phosphoryl transfer, requiring that the gamma-phosphoryl of ATP be closely juxtaposed to the bound cosubstrate.
(7) These results suggest a critical role for an iron-liganding moiety that is abundantly present in PMN, marginally so in neutroplasts, and not at all in purified enzymatic systems--a moiety that we presume catalyzes very toxic O2 specie generation in the vicinity of juxtaposed erythrocyte targets.
(8) He frequently intermingled two sentences to convey a given concept, juxtaposing words in grammatically unacceptable ways.
(9) A suppurative gastritis with full thickness perforations of the stomach wall associated with Gasterophilus intestinalis larvae had extended to the juxtaposed organ initiating an extensive suppurative splenitis.
(10) When the fields were juxtaposed, chromatic sensitivity declined with viewing duration.
(11) Aristapedioid is the result of a P element mediated inversion which juxtaposes unrelated DNA adjacent to Suppressor 2 of zeste, causing a gain of function mutation in that gene.
(12) It also suggests that both cohesive acts involve at least dimeric associations of molecules or molecular complexes located within or on juxtaposed membranes.
(13) Juxtaposed genes with divergent transcriptional polarity were prevalent.
(14) It is concluded that RNA splicing between inadvertently juxtaposed donor and acceptor signals was responsible for the observed deletions.
(15) We conclude that the gene classes 2, 4, and 5 are closely juxtaposed in the normal Chinese hamster genome and comprise one amplicon in resistant cells.
(16) The interconnected helices are juxtaposed so that the continuous strands of each helix generate an antiparallel alignment, and the two interchanged strands do not cross at the centre.
(17) Most human follicular lymphomas bear the specific t(14;18) translocation that juxtaposes the 3' region of bcl-2 to the IgH gene on chromosome 14q+.
(18) When a group of earlier visual fields is compared with a group of later ones utilizing the statistical program delta-change, the results of regression analysis, based on data from program delta-series, are juxtaposed to the results of the t test with very good correlation.
(19) These arrangements were evaluated for whether they could incorporate the disulfide bond, satisfy loop length constraints, and juxtapose the two basic regions.
(20) Analysis of mutant constructs revealed that only 83 bp of H-2 DNA, consisting of the enhancer juxtaposed to the basal promoter, was sufficient for this differential expression.