(1) Side effect incidence in patients treated with the paracetamol-sobrerol combination (3.7%) was significantly lower than that observed in subjects treated with paracetamol (6.1% - P less than 0.01), salicylics (25.1% - P less than 0.001), pyrazolics (12.6% - P less than 0.001), propionics (20.3%, P less than 0.001) or other antipyretics (17.9% - P less than 0.001).
(2) The results show that both drugs possess sedative, antispasmodic, antipyretic, antiinflammatory, cardiotonic and hypotensive effects, the strength of effect and toxicity being similar.
(3) The effects of continuous illumination, adrenalectomy and induction or inhibition of microsomal enzymes on antipyretic action of phenacetin were evaluated.
(4) This compound did not affect normal body temperature of rabbits and rats, this observation being similar to that noted with antipyretic analgesics and nonsteroidal anti-inflammatory agents.
(5) The compounds were subjected to pharmacological screening, and some were found to possess antiinflammatory and antipyretic properties.
(6) Since prostaglandins (PG) are known to potentiate (facilitate) the peripheral effects of BK and display a hyperthermic action, their synthesis being inhibited by antipyretics, we studied the effect of indomethacin and paracetamol on the BK-induced rise in rectal temperature in rabbits.
(7) Decrease in Te induced by hypothalamic cooling was also reversed by the intravenous injection of antipyretics.
(8) The benzisothiazoliltetrazoles showed high antipyretic activity and each tetrazole, except one, was appreciably more potent than the corresponding acid.
(9) Pyridyl-biphenylyl-acetamide (diphenpyramide, Z-876) is a new bisphenylalcanoic derivative with marked anti-inflammatory, analgesic, antipyretic and uricosuric properties.
(10) Paracetamol may be recommended as a safe analgesic-antipyretic during pregnancy and labour.
(11) The influence of initial temperature on the magnitude of the response to an antipyretic drug is a previously unappreciated finding with potential impact on pharmacodynamic investigations of antipyretic medications.
(12) Antipyretic and analgesic effects for dapsone have been demonstrated and are similar to those produced by phenylbutazone.
(13) A series of acyloxy- and alkyloxymethyl esters of meclofenamic, flufenamic and mefenamic acids has been synthesized and its antiinflammatory, analgesic and antipyretic activities have been compared with those of the corresponding acids and the methyl, beta,gamma-isopropylidene-dioxypropyl, N,N-diethylaminoethyl esters.
(14) An open trial of piroxicam, a new nonsteroidal anti-inflammatory agent with long-lasting analgesic and antipyretic activities, was carried out on 49 children as outpatients with viral rhinopharyngitis.
(15) Three studies that describe antipyretic bioassay are detailed.
(16) The second place was held by antipyretics, most frequently Acylpyrin, during the summer months--20.4%.
(17) The antiinflammatory activity of the novel pyrrolidin-2-one derivative N-methoxy-3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-o ne (E-5110) was investigated and compared with those of indomethacin and piroxicam in various antiinflammatory, analgesic and antipyretic animal models.
(18) By these criteria, meclofenamic acid is a highly potent, acceptably safe and exceptionally well tolerated anti-inflammatory-antipyretic agent in rats when compared with other such drugs.
(19) These findings suggest that ibuprofen is a good alternative to paracetamol as an antipyretic.
(20) Acetaminophen is an effective mild analgesic and antipyretic agent.
Kairine
Definition:
(n.) A pale buff or white crystalline alkaloid derived from quinoline, and used as an antipyretic in medicine.