(1) Side effect incidence in patients treated with the paracetamol-sobrerol combination (3.7%) was significantly lower than that observed in subjects treated with paracetamol (6.1% - P less than 0.01), salicylics (25.1% - P less than 0.001), pyrazolics (12.6% - P less than 0.001), propionics (20.3%, P less than 0.001) or other antipyretics (17.9% - P less than 0.001).
(2) The results show that both drugs possess sedative, antispasmodic, antipyretic, antiinflammatory, cardiotonic and hypotensive effects, the strength of effect and toxicity being similar.
(3) The effects of continuous illumination, adrenalectomy and induction or inhibition of microsomal enzymes on antipyretic action of phenacetin were evaluated.
(4) This compound did not affect normal body temperature of rabbits and rats, this observation being similar to that noted with antipyretic analgesics and nonsteroidal anti-inflammatory agents.
(5) The compounds were subjected to pharmacological screening, and some were found to possess antiinflammatory and antipyretic properties.
(6) Since prostaglandins (PG) are known to potentiate (facilitate) the peripheral effects of BK and display a hyperthermic action, their synthesis being inhibited by antipyretics, we studied the effect of indomethacin and paracetamol on the BK-induced rise in rectal temperature in rabbits.
(7) Decrease in Te induced by hypothalamic cooling was also reversed by the intravenous injection of antipyretics.
(8) The benzisothiazoliltetrazoles showed high antipyretic activity and each tetrazole, except one, was appreciably more potent than the corresponding acid.
(9) Pyridyl-biphenylyl-acetamide (diphenpyramide, Z-876) is a new bisphenylalcanoic derivative with marked anti-inflammatory, analgesic, antipyretic and uricosuric properties.
(10) Paracetamol may be recommended as a safe analgesic-antipyretic during pregnancy and labour.
(11) The influence of initial temperature on the magnitude of the response to an antipyretic drug is a previously unappreciated finding with potential impact on pharmacodynamic investigations of antipyretic medications.
(12) Antipyretic and analgesic effects for dapsone have been demonstrated and are similar to those produced by phenylbutazone.
(13) A series of acyloxy- and alkyloxymethyl esters of meclofenamic, flufenamic and mefenamic acids has been synthesized and its antiinflammatory, analgesic and antipyretic activities have been compared with those of the corresponding acids and the methyl, beta,gamma-isopropylidene-dioxypropyl, N,N-diethylaminoethyl esters.
(14) An open trial of piroxicam, a new nonsteroidal anti-inflammatory agent with long-lasting analgesic and antipyretic activities, was carried out on 49 children as outpatients with viral rhinopharyngitis.
(15) Three studies that describe antipyretic bioassay are detailed.
(16) The second place was held by antipyretics, most frequently Acylpyrin, during the summer months--20.4%.
(17) The antiinflammatory activity of the novel pyrrolidin-2-one derivative N-methoxy-3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-o ne (E-5110) was investigated and compared with those of indomethacin and piroxicam in various antiinflammatory, analgesic and antipyretic animal models.
(18) By these criteria, meclofenamic acid is a highly potent, acceptably safe and exceptionally well tolerated anti-inflammatory-antipyretic agent in rats when compared with other such drugs.
(19) These findings suggest that ibuprofen is a good alternative to paracetamol as an antipyretic.
(20) Acetaminophen is an effective mild analgesic and antipyretic agent.
Pyretic
Definition:
(a.) Of or pertaining to fever; febrile.
Example Sentences:
(1) In addition to these anti-inflammatory activities, auranofin had almost equal anti-analgesic and anti-pyretic activity to that of indomethacin.
(2) However, when NaASA was administered after pyrogen, it uniformly antagonized the pyretic effect causing a return of the discharge to the control rate.
(3) A diminished pyretic reaction during aseptic inflammation in rabbits with diabetes was apparently associated with the reduced capacity of leukocytes of the inflammatory focus to release pyrogens, determining the fever.
(4) Controversy exists regarding (a) whether rats become tolerant, or sensitized, to morphine-induced hyperthermia and (b) the directionality of the conditioned pyretic effects of morphine.
(5) Pyretic activity was detected both in the fractions with LAF activity and in those with cytotoxic activity for L-929 cells.
(6) A pyretic response was observed in intravenous and intramammary treatment groups after endotoxin treatment.
(7) The overall pyretic response is more dramatic in female rats than in male rats.
(8) These results suggest that anti-inflammatory, analgesic and anti-pyretic activities of TA are generally a little weaker than those of ibuprofen, and the mode of action of TA is similar to that of a typical acidic non-steroidal anti-inflammatory drug such as ibuprofen, indomethacin or phenylbutazone.
(9) Etoclofene, the ethoxy methyl ester of N-(2,6-dichloro-m-tolyl)anthranilic acid, showed potent anti-inflammatory, anti-pyretic and peripheral analgesic activity in several experimental models of inflammation.
(10) The analgesic, anti-pyretic and anti-inflammatory effects of FI-302, N-(3-piperidinopropyl)-4-methyl-6-trifluoromethyl-furo [3,2-b]indole-2-carboxamide, a newly synthesized tricyclic compound, were investigated in comparison with those of nonsteroidal anti-inflammatory drugs (NSAIDs).
(11) An evaluation of the in situ bacteriologic status of a total parenteral nutrition (TPN) catheter, when the patient is pyretic but the cause of infection is not obvious, permits continued use of the catheter if the result is negative, as opposed to removal of the suspected catheter.
(12) The compounds showed weaker antipyretic activity than acetylsalicylic acid in pyretic animals.
(13) In 22 patients with liver cirrhosis, 59.19pc had subnormal temperatures and 9.1pc were pyretic.
(14) Asymptomatic typhus infection was regularly modelled in guinea pigs with increased resistance to Rickettsia prowazeki; this infection was characterized by the presence of immunological shifts in the blood and immunity to reinfection, persistenc of rickettsia in the organs of animals in the absence of pyretic reaction and periorchites.
(15) Diabetic rabbits displayed a statistically significant reduction of the pyretic index in comparison with control.
(16) D-penicillamine did not show any anti-inflammatory, anti-analgesic or anti-pyretic activity.
(17) The compound reduced the pyretic, metabolic and vasoconstricting activity of pyrogen.
(18) Anti-inflammatory, analgesic and anti-pyretic activities of three new 5-(Indan-1'-yl)tetrazoles and anti-inflammatory activity of corresponding carboxamides were compared to those of standard drugs, phenylbutazone and aspirin.
(19) A study was made of the development of pyretic reaction to the administration of a bacterial lipopolysaccharide (pyrogenal) after preliminary treatment of rabbits with actinomycin D and cortisone.
(20) Separate investigations of treatment given to 394 children before presentation at hospital with severe and mild malaria was consistent with the reports in the community of high usage of shop-bought anti-malarials and anti-pyretics.