(1) Other redox compounds without antiscorbutic activity and an antioxidant were ineffective.
(2) There is a certain presumptive evidence for believing than AA has functions other than the simple prevention of classical scurvy; whether these extra-antiscorbutic functions are attributable to AA itself, or to one or more of its metabolites, is not known.
(3) D-Erythorbic acid is an epimer of L-ascorbic acid, but lacks antiscorbutic activity.
(4) Two isomers of LAA, D-isoascorbic acid and D-ascorbic acid, which have weaker antiscorbutic activity than that of LAA, also produced the L-CFC growth-enhancing effect, but to a lesser degree than that of LAA.
(5) Ascorbic acid 2-O-alpha-glucoside (AA-2G) has been reported to have antiscorbutic activity in guinea pigs.
(6) The antiscorbutic effect of dehydro-L-ascorbic acid (DAsA) was investigated in vitamin C-deficient guinea pigs.
(7) These data indicate that DAsA has considerably less antiscorbutic activity than AsA in vitamin C-deficient guinea pigs.
(8) Isomers of L-ascorbic acid with less antiscorbutic activity also promoted plasmacytoma colony formation, but less effectively.
(9) Possible reasons for the lack of antiscorbutic activity of ascorbic acid-2-sulphate in guinea pigs is discussed.
(10) In the year 1795, a British East Indiaman bound for China had a sick sailor on board who was diagnosed as having testis cancer by the ship's surgeon, who then treated him with an antiscorbutic diet, because scurvy was rampant among the sailors.
(11) The rationale for investigating D-isoascorbic acid, an isomer of L-ascorbic acid which has limited antiscorbutic activity, is discussed.
(12) Given the many extra-antiscorbutic functions of the vitamin, the Recommended Dietary Allowances (RDA) should not just prevent deficiency disease but should aim at providing sufficient amounts for all vitamin C-dependent functions to operate at full capacity.
(13) Examination of the physiological activity of flavonoids in relation to their antiscorbutic properties shows that some of these compounds, the flavan-3-ols, have a particular nutritional impact and consequently should be distinguished from the rest of the flavonoids and polyphenols.
(14) Tissue saturation with AA would appear to provide a good insurance against defects in these extra-antiscorbutic areas.
Scorbutic
Definition:
(a.) Alt. of Scorbutical
Example Sentences:
(1) Since our previous study revealed low basal testosterone (T) levels and a failure in response to an acute stimulation with human chorionic gonadotropin (HCG) despite of a good response to chronic stimulation in scorbutic mutant rats, time course of the response to HCG was studied and plasma LH level was measured in young adult rats deficient in ascorbic acid for 3 weeks.
(2) This correlates with the observation that a major fraction of the hydroxyproline in the scorbutic cultures was found in the medium as small molecular weight peptides.
(3) Plasma LH levels in unstimulated scorbutic rats were about 40% of those in ascorbutic rats.
(4) In mesencephalic cultures the cellular ascorbic acid content drops sharply to undetectable levels when no ascorbic acid is added to the medium, thus creating a model of scorbutic neuronal tissue and affording the study of ascorbic acid's effects on mesencephalic cell development and function.
(5) However, there was no difference in the production of testosterone from progesterone between ovaries of scorbutic and ascorbutic ODS rats.
(6) This decreased bactericidal activity can be reversed by adding supplements of the vitamin to the diet of scorbutic animals.
(7) AA-2G was found to exhibit obvious therapeutic effect in scorbutic guinea pigs by its repeated oral administrations.
(8) Higher mean cortisol values were found in the scorbutic group than in the controls, correlating with high levels of NAF-stimulated ACL activity.
(9) The increased level of collagen synthesis after different exposure times could also be achieved by only brief treatment (10 h) of parallel scorbutic (ascorbic-acid-deficient) cultures with ascorbic acid.
(10) A significant increase in ovarian aromatase activity was observed in scorbutic ODS rats.
(11) We have previously reported that scorbutic and fasted guinea pig sera contain an insulin-like growth factor-I (IGF-I)-reversible inhibitor of collagen, proteoglycan, and DNA synthesis in cultured cells.
(12) Cultures treated with 0.2 mM ascorbic acid were compared with controls (scorbutic cultures) by using morphological and biochemical indices.
(13) His dental condition was diagnosed as a scorbutic condition, requiring systemic medication.
(14) Following initial weight gain, reduction in appetite and pronounced weight loss occurred in scorbutic unsupplemented guinea-pigs.
(15) Osteogenic disorder syndrome rats are unable to synthesize ascorbic acid owing to the lack of l-gulonolactone oxidase, and become scorbutic within a few weeks without the supply of ascorbic acid.
(16) Old scars break open in scorbutic patients because (1) the rate of collagen degradation is greater in an old scar than it is in normal skin, and (2) the rate of collagen synthesis is diminished throughout the body in ascorbate deficiency.
(17) While there was an early uptake of 59Fe into haem in these organs, some redistribution occurred with time, since most of the 59Fe was in a non-haem fraction by 24 h. In a final experiment the distribution and fate of 59Fe-ferritin was studied in scorbutic animals treated with phenylhydrazine.
(18) The response of "scorbutic" liver microsomes to the inhibitor Metyrapone (2-methyl-1,2 di (3-pyridyl) propan-1-one) was different from that of liver microsomes from non-scorbutic guinea-pigs.
(19) A single subcutaneous injection of HCG (200 IU) elevated T levels only slightly in plasma and not in testicular tissues of scorbutic rats 1 h after the injection when the levels in ascorbutic rats reached a maximum, while it yielded the same response pattern as in ascorbutic rats after 3 h. A pretreatment with HCG to scorbutic rats for 1 or 4 days resulted in the same response of plasma T as in ascorbutic rats.
(20) Subsequent chemical analyses of the striatum showed no evidence of lasting damage to nigrostriatal dopaminergic neurons in MPTP treated guinea pigs on normal diet, and minimal evidence of permanent damage to these neurons in scorbutic animals.