(1) Other redox compounds without antiscorbutic activity and an antioxidant were ineffective.
(2) There is a certain presumptive evidence for believing than AA has functions other than the simple prevention of classical scurvy; whether these extra-antiscorbutic functions are attributable to AA itself, or to one or more of its metabolites, is not known.
(3) D-Erythorbic acid is an epimer of L-ascorbic acid, but lacks antiscorbutic activity.
(4) Two isomers of LAA, D-isoascorbic acid and D-ascorbic acid, which have weaker antiscorbutic activity than that of LAA, also produced the L-CFC growth-enhancing effect, but to a lesser degree than that of LAA.
(5) Ascorbic acid 2-O-alpha-glucoside (AA-2G) has been reported to have antiscorbutic activity in guinea pigs.
(6) The antiscorbutic effect of dehydro-L-ascorbic acid (DAsA) was investigated in vitamin C-deficient guinea pigs.
(7) These data indicate that DAsA has considerably less antiscorbutic activity than AsA in vitamin C-deficient guinea pigs.
(8) Isomers of L-ascorbic acid with less antiscorbutic activity also promoted plasmacytoma colony formation, but less effectively.
(9) Possible reasons for the lack of antiscorbutic activity of ascorbic acid-2-sulphate in guinea pigs is discussed.
(10) In the year 1795, a British East Indiaman bound for China had a sick sailor on board who was diagnosed as having testis cancer by the ship's surgeon, who then treated him with an antiscorbutic diet, because scurvy was rampant among the sailors.
(11) The rationale for investigating D-isoascorbic acid, an isomer of L-ascorbic acid which has limited antiscorbutic activity, is discussed.
(12) Given the many extra-antiscorbutic functions of the vitamin, the Recommended Dietary Allowances (RDA) should not just prevent deficiency disease but should aim at providing sufficient amounts for all vitamin C-dependent functions to operate at full capacity.
(13) Examination of the physiological activity of flavonoids in relation to their antiscorbutic properties shows that some of these compounds, the flavan-3-ols, have a particular nutritional impact and consequently should be distinguished from the rest of the flavonoids and polyphenols.
(14) Tissue saturation with AA would appear to provide a good insurance against defects in these extra-antiscorbutic areas.
Scurvy
Definition:
(n.) Covered or affected with scurf or scabs; scabby; scurfy; specifically, diseased with the scurvy.
(n.) Vile; mean; low; vulgar; contemptible.
(n.) A disease characterized by livid spots, especially about the thighs and legs, due to extravasation of blood, and by spongy gums, and bleeding from almost all the mucous membranes. It is accompanied by paleness, languor, depression, and general debility. It is occasioned by confinement, innutritious food, and hard labor, but especially by lack of fresh vegetable food, or confinement for a long time to a limited range of food, which is incapable of repairing the waste of the system. It was formerly prevalent among sailors and soldiers.
Example Sentences:
(1) This symptom is connected with high blood levels of cortisol, which are probably also involved in the injuries to connective tissue known in scurvy.
(2) We report three patients who highlight the epidemiology, clinical features, and differential diagnosis of scurvy.
(3) Scurvy developed in a 56-year-old man with poor dietary intake and was associated with knee hemarthroses and synovial thickening.
(4) This was soon accompanied by other “medicinal” drinks such as the gimlet, to avoid scurvy on ship, and pink gin, which was said to help seasickness.
(5) This study shows that guinea pigs fed 100 times the amount of vitamin C needed for growth and for prevention of scurvy have elevated levels of complement component C1q.
(6) Feed samples were submitted to a laboratory for analysis and were confirmed deficient in vitamin C. Follow-up radiographs showed large calcifying subperiosteal hematomas in epiphyseometaphyseal regions, consistent with a diagnosis of scurvy.
(7) A case of scurvy during prolonged stay in hospital is presented.
(8) In either case it implies the accumulation in scurvy of low-molecular-weight peptides enriched in proline and deficient in hydroxyproline and could explain the failure to accumulate a high-molecular-weight collagen deficient in hydroxyproline.
(9) Scurvy, which is caused by a deficiency in vitamin C, is mostly attributed to the decreased synthesis of collagen.
(10) Total IGFBP-3 in the experimental sera was increased about 30%, while there was little effect of scurvy or fasting on the level of BP-3 activity isolated by acid extraction of the high mol wt region of the S200 column.
(11) Familiarity with the risk factors for and clinical manifestation of scurvy can facilitate earlier diagnosis.
(12) Two types of pathologic state are unquestionably the concern of vitaminotherapy: More or less specific and intense vitamin deficiencies: Rickets, scurvy, beri beri, pellagra, vitamin deficiency related to alcohol consumption, polyneuritis, encephalopathy, malabsorption, mucoviscidosis, etc.
(13) The incidental discovery of scurvy in a patient with a symptomatic hiatal hernia has led to the identification of 9 other individuals with chemically proved vitamin C deficiency secondary to an expressed aversion to "acid" food in any form.
(14) The osteogenic disorder Shionogi (ODS) rat is a mutant Wistar rat that is subject to scurvy, because it lacks L-gulono-gamma-lactone oxidase, a key enzyme in L-ascorbic acid biosynthesis.
(15) Old people living alone and in poverty are most at risk for developing scurvy, but the diagnosis may be missed unless the physician is aware of it.
(16) In OD rats, the dietary requirement of ascorbic acid to maintain normal growth and prevent any signs of scurvy is about 300 mg of ascorbic acid per kilogram diet.
(17) Clinical manifestations of scurvy were exhibited, however, when animals receiving no ascorbic acid supplement were treated with the steroid hormones for 7 d. All of these animals died by d 10.
(18) The common cold studies indicate that the amounts of vitamin C which safely protect from scurvy may still be too low to provide an efficient rate for other reactions, possibly antioxidant in nature, in infected people.
(19) Moderate vitamin C deficiency, in the absence of scurvy, results in alteration of antioxidant chemistries and may permit increased oxidative damage.
(20) This is illustrated by some epidemiological examples (ergotism, scurvy, yellow fever, English sweat, diphtheria and malaria).