(a.) Believed to cause a revulsion of fluids or of humors from one part to another.
(a.) Counteracting spasms; antispasmodic.
(n.) An antispastic agent.
Example Sentences:
(1) These data are evidence of a specific glycinergic interaction with putative antispastic agents and can explain some conflicting effects of memantine in experimentally induced seizures.
(2) The three patients have been observed for more than 1 year, during which time the antispastic activity of intrathecally infused baclofen has remained stable.
(3) After stressing the uncertainties of classifying the syndrome exactly and the part played by psychosomatism in its aetiopathogenesis, some forms of acupuncture have been attempted as alternatives to psychodrugs and antispastic substances.
(4) The results support the role of cyproheptadine as an antispastic medication.
(5) In 7 patients MI developed when antispastic agents were not used and in 2, when angina persisted even under treatment with calcium antagonist.
(6) The symptoms developed by the chemical destruction of the interneurones of the spinal cord, with rigidity and spasticity of the hind limbs, are suitable for testing antispastic drugs.
(7) The effectiveness of an antispasticity drug may be too subtle to be perceived subjectively and objectively.
(8) In about one third of patients with violent spasticity due to spinal trauma, multiple sclerosis, and diffuse brain injury adequate control with oral antispastic medication cannot be achieved and successful rehabilitation is severely handicapped.
(9) These results indicate that eperisone possesses the property of a Ca antagonist on smooth muscle tissues of the guinea-pig basilar artery, in addition to the action of antispastic agent, i.e., this agent blocks the voltage-dependent influx of Ca at the smooth muscle membrane, but not at the nerve terminals, and inhibits the action of Ca in cells through inhibition of the contractile protein.
(10) The present study underscores that neither baclofen nor tizanidine are ideal antispastic drugs, and emphasize the need for further research.
(11) The literatures of two antispastic drugs, baclofen and dantrolene sodium, were studied bibliometrically for their first decade and were found to be generally similar.
(12) Spasticity greatly interfered with their activity in daily life and was resistant to oral antispastic medications.
(13) We have studied the effect of isometheptene, an indirectly acting sympathomimetic with analgesic and antispastic properties, on secretin-cholecystokinin-stimulated pancreatic and biliary outputs.
(14) Although there were no statistically significant differences between the two drugs, the global assessment of antispastic efficacy revealed a nearly significant difference (p = 0.057) in favour of tizanidine and the global assessment of tolerability was also in favour of tizanidine.
(15) Intrathecal administration of antispastic medications allows high concentrations of drug near the site of action, which limits side effects.
(16) However, antispastic drugs are usually ineffective.
(17) A double-blind placebo trial was taken with Lioresal, and antispasticity drug acting on the spinal cord level.
(18) A genetically determined syndrome of spasticity in the rat permits the quantitative evaluation of the antispastic effects of drugs by recording activity in the electromyogram (EMG) from a hind limb extensor muscle.
(19) The antispastic efficacy of tizanidine was greater after 8 weeks than after 2 weeks, whereas the efficacy of baclofen decreased slightly with time.
(20) A double-blind placebo trial was taken with Lioresal, an antispasticity drug acting on the spinal cord level.
Diminish
Definition:
(v. t.) To make smaller in any manner; to reduce in bulk or amount; to lessen; -- opposed to augment or increase.
(v. t.) To lessen the authority or dignity of; to put down; to degrade; to abase; to weaken.
(v. t.) To make smaller by a half step; to make (an interval) less than minor; as, a diminished seventh.
(v. t.) To take away; to subtract.
(v. i.) To become or appear less or smaller; to lessen; as, the apparent size of an object diminishes as we recede from it.
Example Sentences:
(1) Diminished CMD was most common with AR (7 of 12) but was also seen with acute tubular necrosis (2 of 6) and cyclosporin toxicity (2 of 3).
(2) If women psychiatrists are to fill some of the positions in Departments of Psychiatry, which will fall vacant over the next decade, much more attention must be paid to eliminating or diminishing the multiple obstacles for women who chose a career in academic psychiatry.
(3) The results indicated that the role of contact inhibition phenomena in arresting cellular proliferation was diminished in perfusion system environments.
(4) In vitro studies in cardiac Purkinje fibers suggested that reversal of amitriptyline-induced cardiac membrane effects by sodium bicarbonate may be attributed not only to alkalinization but also to increased in extracellular sodium concentration, diminishing the local anesthetic action of amitriptyline and resulting in less sodium channel block.
(5) Virus replication in nasal turbinates was not diminished while infection in the lung was suppressed sufficiently for the infected mice to survive the infection.
(6) The last stems from trends such as declining birth rate, an increasingly mobile society, diminished importance of the nuclear family, and the diminishing attractiveness of professions involved with providing maintenance care.
(7) In contrast, insertion of a pre-S(1) sequence between HBcAg residues 75 and 83 abrogated recognition of HBcAg by 5 of 6 anti-HBc monoclonal antibodies and diminished recognition by human polyclonal anti-HBc.
(8) In addition, the activity of the large cells diminished with time after primary immunization, but that of the small cells remained stable.
(9) The antibody reacted with adult as well as with cord red cells, and its reactivity was strongly diminished by treatment of the cells with neuraminidase and to a lesser degree by treatment with protease.
(10) The concomitant reduction in aortic pressure and increase in heart rate following total occlusion of the portal vein were most pronounced during the first weeks after stenosis, and were probably due to diminished venous return to the heart.
(11) Conversely, the latter diminished basal plasma glucose levels.
(12) Subsequently, the inflammatory reaction diminishes, as can be seen on smears from tympanic effusions.
(13) Both Apo AI (48%) and Apo AII (5.5%) were greatly diminished and Apo E was present in remarkably high amounts (39%) with two additional isoforms (Apo E'1 and Apo E'2).
(14) (3) The diminished autophosphorylation rate was due to a decreased responsiveness of the kinase activity to the action of insulin.
(15) The isoenzyme mobility diminished in both tumour chromatin extracts, and the slow migrating gamma isoenzyme exhibited sensitivity to L-cysteine inhibition.
(16) Segmental function was diminished an average of 67.8% in "noses" and 46.6% in "bridges".
(17) Flexion of the knee beyond 40 degrees progressively diminished viability of the edges of the wound, particularly the lateral edge.
(18) EEG waves were similar during Aw and Qw but they diminished in amplitude and frequency when passing from these states to Qs, and both parameters increased during As.
(19) After 3-5 days of side-arm traction, swelling had usually diminished sufficiently to allow the elbow to be safely hyperflexed to stabilize the fracture after elective closed reduction.
(20) In the patients with aplastic anaemia the iron flux was diminished, but never eliminated, demonstrating that the exchangeable compartment was not solely erythroblastic, but included non-erythroid transferrin receptors.