(a.) Believed to cause a revulsion of fluids or of humors from one part to another.
(a.) Counteracting spasms; antispasmodic.
(n.) An antispastic agent.
Example Sentences:
(1) These data are evidence of a specific glycinergic interaction with putative antispastic agents and can explain some conflicting effects of memantine in experimentally induced seizures.
(2) The three patients have been observed for more than 1 year, during which time the antispastic activity of intrathecally infused baclofen has remained stable.
(3) After stressing the uncertainties of classifying the syndrome exactly and the part played by psychosomatism in its aetiopathogenesis, some forms of acupuncture have been attempted as alternatives to psychodrugs and antispastic substances.
(4) The results support the role of cyproheptadine as an antispastic medication.
(5) In 7 patients MI developed when antispastic agents were not used and in 2, when angina persisted even under treatment with calcium antagonist.
(6) The symptoms developed by the chemical destruction of the interneurones of the spinal cord, with rigidity and spasticity of the hind limbs, are suitable for testing antispastic drugs.
(7) The effectiveness of an antispasticity drug may be too subtle to be perceived subjectively and objectively.
(8) In about one third of patients with violent spasticity due to spinal trauma, multiple sclerosis, and diffuse brain injury adequate control with oral antispastic medication cannot be achieved and successful rehabilitation is severely handicapped.
(9) These results indicate that eperisone possesses the property of a Ca antagonist on smooth muscle tissues of the guinea-pig basilar artery, in addition to the action of antispastic agent, i.e., this agent blocks the voltage-dependent influx of Ca at the smooth muscle membrane, but not at the nerve terminals, and inhibits the action of Ca in cells through inhibition of the contractile protein.
(10) The present study underscores that neither baclofen nor tizanidine are ideal antispastic drugs, and emphasize the need for further research.
(11) The literatures of two antispastic drugs, baclofen and dantrolene sodium, were studied bibliometrically for their first decade and were found to be generally similar.
(12) Spasticity greatly interfered with their activity in daily life and was resistant to oral antispastic medications.
(13) We have studied the effect of isometheptene, an indirectly acting sympathomimetic with analgesic and antispastic properties, on secretin-cholecystokinin-stimulated pancreatic and biliary outputs.
(14) Although there were no statistically significant differences between the two drugs, the global assessment of antispastic efficacy revealed a nearly significant difference (p = 0.057) in favour of tizanidine and the global assessment of tolerability was also in favour of tizanidine.
(15) Intrathecal administration of antispastic medications allows high concentrations of drug near the site of action, which limits side effects.
(16) However, antispastic drugs are usually ineffective.
(17) A double-blind placebo trial was taken with Lioresal, and antispasticity drug acting on the spinal cord level.
(18) A genetically determined syndrome of spasticity in the rat permits the quantitative evaluation of the antispastic effects of drugs by recording activity in the electromyogram (EMG) from a hind limb extensor muscle.
(19) The antispastic efficacy of tizanidine was greater after 8 weeks than after 2 weeks, whereas the efficacy of baclofen decreased slightly with time.
(20) A double-blind placebo trial was taken with Lioresal, an antispasticity drug acting on the spinal cord level.
Spasm
Definition:
(v. t.) An involuntary and unnatural contraction of one or more muscles or muscular fibers.
(v. t.) A sudden, violent, and temporary effort or emotion; as, a spasm of repentance.
Example Sentences:
(1) The generally accepted hypothesis is a coronary spasm but a direct cardiotoxicity of 5-FU cannot be.
(2) Oculomotor paresis with cyclic spasms is a rare syndrome, usually noticeable at birth or developing during the first year of life.
(3) The ophthalmic headache's crisis is caused, in fact, by a spasm of convergence on an unknown exophory of which the amplitude of fusion is satisfying, and the presence of which can only be seen with test under screen.
(4) The present case indicates that the possibility of osseous spines impinging on the facial nerve should be considered in all cases of facial spasm.
(5) The coronary arteriography reveals a spasm in the normal left anterior descendens artery.
(6) Increasing awareness of disorders such as coronary arterial spasm, functional impairment of subendocardial blood flow and the possible role of variant patterns of anatomic distribution of the coronary arterial tree, will provide a better understanding of their significance as determining or contributing factors in patients with the anginal syndrome.
(7) Thus one may speculate that endothelin plays a role in the coronary spasm which has been shown in patients with angina pectoris.
(8) in 1937, the arterial spasm may have occurred at the time of cerebral embolism.
(9) Coronary spasm was provoked by ergonovine maleate in four of 12 patients in group A (33%) and in three patients in group B (18%).
(10) In 2 cases, sublingual nitroglycerin failed to completely relieve the spasm.
(11) Furthermore, an association of tiapride-corticoids was effective in treating post-anaesthetic spasm of the glottis.
(12) Case histories of two patients with hypertensive LES and normal peristalsis in the body of the esophagus are contrasted to that of a patient with a hypertensive LES and diffuse esophageal spasm.
(13) Whether they affect ureteral motility in vivo or whether they can counteract ureteral spasm associated with ureteral stones have not been established.
(14) Thrombotic occlusion, in association with varying degrees of plaque disruption and coronary artery spasm, represents the major cause of acute myocardial infarction (AMI).
(15) The patients with spasm on top of a fixed organic lesion underwent a successful aorto-coronary bypass graft together with resection of the pre- and sub-aortic nerve plexus.
(16) In vitro tests with isolated trachea or ileum of guinea pigs show that flupirtine possesses no or very weak antagonism against histamine-induced spasms.
(17) The spasms were inhibited by gallopamil (100 nM) and diltiazem (1 microM).
(18) Indeed this procedure is the only one which can act in a fitted manner on muscular spasms responsible of more than 60% of convergent squints.
(19) Such an exercise response should suggest significant fixed coronary stenosis in addition to coronary spasm.
(20) Evidence is provided for the concept of enlarged spasms (phenomenon of the spastic dominant) common to peptic ulcer.