What's the difference between approval and conformation?

Approval


Definition:

  • (n.) Approbation; sanction.

Example Sentences:

  • (1) Currently, photodynamic therapy is under FDA-approved clinical investigational trials in the treatment of tumors of the skin, bronchus, esophagus, bladder, head and neck, and of gynecologic and ocular tumors.
  • (2) The genome characterization of the typing strains for all 13 species of the genus Staphylococcus, included into the Approval List of the Names of Bacterial (1980), is presented.
  • (3) Currently there are no IOC approved definitive tests for these hormones but highly specific immunoassays combined with suitable purification techniques may be sufficient to warrant IOC approval.
  • (4) The toluene group were more approving in their attitudes towards taking other drugs.
  • (5) No one knows if this drug will be approved for use by American physicians.
  • (6) Britain First applied to use seven slogans in the elections and four were rejected, but the remaining three, including the slogan relating to Rigby, were approved by the watchdog.
  • (7) Yet, polls have Maryland voters approving same-sex marriage by 14 to 20 points.
  • (8) Guidelines are presented for pharmacist coordination of the importation for use by institutionalized patients of drugs not currently approved by the FDA.
  • (9) Mal’s age alone was enough to earn him a significant amount of street cred in our misfit group of teenage boys, yet it was his history of extreme violence that ensured his approval rating was sky high.
  • (10) However, the law minister indicated he would allow the supreme court to approve a draft of the letter.
  • (11) Shenhua Watermark Coal, a subsidiary of the Chinese state-owned Shenhua Group, is waiting for final approval from Hunt for a $1.2bn open-cut coalmine on the edge of the plains, a little more than three kilometres from Hamparsum’s property.
  • (12) An ‘approved’ poster in the student center at Regent University.
  • (13) The final approved log contained 72 problems, 64 of which received importance ratings greater than or equal to 2 on the three-point scale.
  • (14) Masutha said the parole board had made a mistake when they approved Pistorius for early release, but his intervention has been widely criticised by legal experts.
  • (15) But he argued that Obama entered the agreement without approval from Congress, allowing the president to revoke it.
  • (16) Everton announce plan for new stadium in nearby Walton Hall Park Read more The club has set aside £2.5m to commence work on the stadium should its funding proposals – that Elstone claims will give the council an annual profit – gain approval.
  • (17) I am acutely aware that not all of you, by any stretch of the imagination, will approve of everything I have done.
  • (18) The participants strongly preferred the experimental leaflets to the approved leaflets, both with respect to accessibility of the contents (overall preference 78.1% v 17.8%) and ease of understanding the contraindications of drug use (90.2% v 73.7%).
  • (19) In the following, there will be indicated the approved techniques and methods of suturing the cleft palate and a new method will be discussed related to the reciprocal Z-type plastic operation.
  • (20) Unite, which will have to give seven days' notice before calling a strike after winning approval for industrial action in a ballot of the tanker drivers, is expected to finalise a framework that should allow discussions to begin on Monday.

Conformation


Definition:

  • (n.) The act of conforming; the act of producing conformity.
  • (n.) The state of being conformed; agreement; hence; structure, as depending on the arrangement of parts; form; arrangement.

Example Sentences:

  • (1) The interaction of the antibody with both the bacterial and the tissue derived polysialic acids suggests that the conformational epitope critical for the interaction is formed by both classes of compounds.
  • (2) It has been conformed that catalase from bovine liver eliminates only the pro R hydrogen atom from ethanol.
  • (3) The high transition enthalpy for kerasin is ascribed to a lesser accommodation of gauche conformers in the hydrocarbon chains just below the transition temperature.
  • (4) The Tyr side chain had two conformations of comparable energy, one over the ring between the Gln and Asn side chains, and the other with the Tyr side chain away from the ring.
  • (5) In a series of compounds with H2-antihistaminic activity, a conformational analysis was performed based on force field calculations.
  • (6) Recently, we have designed a series of simplified artificial signal sequences and have shown that a proline residue in the signal sequence plays an important role in the secretion of human lysozyme in yeast, presumably by altering the conformation of the signal sequence [Yamamoto, Y., Taniyama, Y., & Kikuchi, M. (1989) Biochemistry 28, 2728-2732].
  • (7) The molecule may already in its native form have an extended conformation containing either free sulfhydryl groups or small S-S loops not affecting mobility in SDS-PAGE.
  • (8) In 0.17 M Na+(aq), tRNA(Phe) exists in its native conformation and the number of strong binding sites (Ka greater than or equal to 10(4)) was estimated to be 3-4 by titration experiments, in agreement with X-ray structural data for crystalline tRNA(Phe) (Jack et al., 1977).
  • (9) In voltage-clamp experiments the ion current flowing through the channels was homogeneous indicating a defined conformation and a uniform size.
  • (10) However, it does not and we therefore propose the presence of an unusual DNA conformation in these regions.
  • (11) We propose that, for a GC base pair in B conformation, there are two amino proton exchangeable states--a cytosine amino proton exchangeable state and a guanine amino proton exchangeable state; both require the disruption of only the corresponding interbase H bond.
  • (12) In air-saturated solutions of DNA, yields of 8-hydroxypurines were not influenced greatly by DNA conformation.
  • (13) A detailed stereochemical analysis of known protein structures has been made which shows that: (1) irregular regions of proteins consist of a limited number of standard structures formed by three, four of more residues; (2) an amino acid residue of a protein can adopt one of the six sterically allowed conformations designated here as alpha, alpha L, beta, gamma, delta, and epsilon.
  • (14) The substructural units, 5-14 linear and 5-14 cyclic, have been used as models for MCH-- H-Asp1-Thr-Met-Arg-Cys-Met-Val-Gly-Arg HO-Val17-Glu-Trp-Cys-Pro-Arg-Tyr-Val in 1H-nmr conformational studies.
  • (15) The conformations of each peptide in various solvents were determined by CD and ir spectroscopy in order to relate immunological to structural properties.
  • (16) All data did, however, conform to normal distribution expectations.
  • (17) The conformations of cysteamine, thiazolidine, and thiazolidine-4-carboxylic acid were determined in aqueous solutions using NMR spectroscopy.
  • (18) This structural change opens the heme pocket and modifies the general conformation of the EF segment, thus explaining the increase in oxygen affinity and the achievement of a three-dimensional structure favoring asparagine deamidation.
  • (19) It is likely that the molecule undergoes a conformational change when it is bound to the receptor.
  • (20) The phenylalanine-dependent conformation and the leucine-dependent conformation differ considerably.