(n.) The Altar; a southern constellation, south of the tail of the Scorpion.
(n.) A name of the great blue and yellow macaw (Ara ararauna), native of South America.
Example Sentences:
(1) The antitumor effect of C18PCA and Ara-C was investigated against the P388 ascites tumor in BDF1 mice.
(2) However, the walker 256 intramuscular tumor did not respond to ARA-C capsules implanted, and the animals died at the same rate as the controls, with large ulcerated tumor masses and some metastasis.
(3) 5 heavily pretreated patients with chronic lymphocytic leukaemia or non-Hodgkin lymphoma resistant to alkylating agents were treated with low-dose cytosine arabinoside (ARA-C).
(4) Rat liver microsomes demethylated ara-DMAP much more rapidly than human liver microsomes did.
(5) Enhanced ara-CTP formation was observed in cells lacking cytidine deaminase (L1 210 and HL60), indicating that 3-deazauridine inhibition of deoxycytidylate deaminase may be important in this drug interaction.
(6) This study demonstrates the mutagenic properties of F-ara-A and ara-A and provides evidence for mechanisms by which the arabinosyl nucleosides induce mutation.
(7) Patient cells had low rates for ara-C transport as compared with human and murine experimental cells and correspondingly low binding capacities for the nucleoside transport inhibitor, nitrobenzylmercaptopurine riboside (NBMPR).
(8) The inhibitions by ara-GTP and 9-beta-D-arabinofuranosyladenine 5'-triphosphate were due to competition or partial competition 5'-triphosphate were due to competition or partial competition with deoxynucleoside triphosphate with the same base.
(9) The incorporation of F-ara-A monophosphate into mRNA resulted in premature termination of the RNA transcript and impaired its functioning as a template for protein synthesis.
(10) Pharmacological studies of 5'-esters of 1 beta-D-arabinofuranosylcytosine (ara-C) were performed in three species (mouse, pig, and man).
(11) These results provide some support for the view that cell kill may not be the only basis for the chemotherapeutic effectiveness of ara-C.
(12) Accelerating test at a constant temperature indicates that liposome-entrapped Ara-A has certain chemical stability.
(13) Although statistically significant, the effect of DP on ara-CTP retention in AML blasts was much less pronounced than that previously observed in L5178Y leukemia.
(14) He was treated with the combination chemotherapy of BACOD with high dose ara-C or methotrexate followed by 4 doses of autologous LAK cell infusion resulting in no significant response.
(15) Regardless whether cyclo-C or ara-C is injected, the plasma decay curve of the resultant ara-C is biphasic, with calculated half-lives of 40 min and 2-2.5 hr.
(16) Serial measurements of DNA synthesis and net intracellular ara-C metabolism demonstrated marked increases in both determinants in day 8 residual tumor when compared with the pretreatment cells for newly diagnosed adults achieving complete remission but not for TST-refractory patients.
(17) Determination of the intracellular content of the active metabolite of ara-C, ara-CTP, excluded more prolonged retention of the drug as the basis for potentiation of cytotoxicity.
(18) With the aim of improving the treatment of AML patients the activities of selected nucleoside metabolizing enzymes of possible implication for the initial metabolism of Ara-C have been studied in leukemic and normal cells.
(19) Ara-C. We conclude that prophylactic CNS therapy may cause cognitive dysfunctions.
(20) This was possible because the Ara test, for volatile compounds (such as vinyl bromide), did not require the use of special vaporization techniques, which are difficult to evaluate quantitatively for mutagenic activity.
Fra
Definition:
(adv. & prep.) Fro.
(n.) Brother; -- a title of a monk of friar; as, Fra Angelo.
Example Sentences:
(1) Taking this into account, we derived equilibrium equations for the fragile X [fra(X)] genotype frequencies.
(2) In this paper we present data on the cognitive abilities analyzed by systematic, standardized psychometric testing in 18 fra(X) boys who participated in a multicenter, longitudinal study.
(3) In female relatives, a relationship was found between the fra(X) carrier status and psychopathology including schizoaffective and major affective disorders.
(4) In the second family, there is a severe mentally retarded 3-year-old boy with fra (X) syndrome who besides typical phenotipic changes also exhibits symptoms of autism.
(5) By using a two-step procedure, it is possible to screen a large population of the mentally retarded for fra(X) without testing each male cytogenetically.
(6) If this proves reliable, a request for a fra(X) cytogenetic analysis could be limited to the clinically screened matching cases, rather than the present costly exercise of testing all undiagnosed intellectually handicapped children.
(7) The precipitating FCE reaction antibody (FRA) in sera of rabbits at 20 min and 24 h after i.v.
(8) In the growth-arrested cells, a small amount of 6.8 kilobase (kb) fra-2 transcript was synthesized and several species (40-46 kilodaltons (kd) of hypophosphorylated fra-2 gene products (Fra-2) were detected.
(9) Since 1985, we have provided coordinated DNA-based and cytogenetic prenatal analysis for couples at risk for offspring afflicted with the fragile X [fra(X)] syndrome.
(10) The fra(12)(q24.2) was expressed in 34%-48% of metaphases in lymphocyte cultures from carriers when BrdU and FdU were added 6.5 h before harvest, while the expression ranged between 5% and 20% when the cultures were treated with BrdU alone.
(11) In the preschool age group the majority of fra(X) boys was mildly mentally retarded.
(12) In addition, one published fra(X) pedigree includes an apparently normal male who expresses cytogenetically the fra(X) site at high frequency and who has 3 daughters.
(13) The FPG, HbA1C and FRA levels in diabetic subjects distributed over a wide range overlapping largely with the distributions of non-diabetic subjects.
(14) The reliable detection of fra(X)(q27.3) in prenatal samples is important for providing genetic counseling.
(15) Some hypotheses, explaining complicated mechanism of fra-X syndrome inheritance are discussed.
(16) The ultrastructural localization of immunoglobulins (IgG, IgA, IgM), complement component (C3c), or fibrinogen-related antigen (FRA) was investigated on 5 biopsy samples from 5 children with idiopathic MN or lupus nephritis using protein A-gold (PAG) complex method.
(17) Although most males with the fragile-X [fra(X)] syndrome do not reproduce, there are 2 published pedigrees that include affected males who have daughters and who thus appear to have transmitted the fragile-X chromosome to their progeny.
(18) Effective Fis fell within the excitatory FRA of a given multi-unit.
(19) Thirteen patients were found to carry fra(X) (6.5%).
(20) In this paper we report the results of a brief examination of verbal learning and memory in 20 heterozygous fragile X [fra(X)] positive females and in 2 control groups of 20 subjects each.