(1) Compared to wild-type (WT) virus, all five of the dTK- mutants were highly resistant (greater than or equal to 500-fold) to BVdU and MMdU, moderately resistant to ACV (50- to 100-fold) and araT (10- to 20-fold), but not resistant to PAA.
(2) Finally, cell populations that differed with respect to physiological characteristics showed no differences in the value of ARAT:FINE correlation.
(3) The ganciclovir resistance of the recombinant was reduced fourfold compared with that of the parental mutant; however, the recombinant remained resistant to HPMPA and HPMPC and hypersensitive to AraT.
(4) Because the position of the ellipse of concentration depended upon the form in which mass was displaced in figures, the fraction of the figure falling within the area of the ellipse (FINE) and the ratio of the ellipse area to the figure's area (ARAT) became decorrelated from each other in figures with massive projections.
(5) However, correlations between ARAT and the coefficient of variation of centroid-to-perimeter distances were altered.
(6) FPL-55712, a specific SRS-A antagonist, inhibited SRS-Agp, SRS-Arat, LTC4 or LTD4-induced contractions at concentrations ranging from 10(-9) M to 10(-6) M without affecting histamine and serotonin responses.
(7) The mean ARAT activities in basal cell carcinomas and squamous cell carcinomas were less than 50% of the control values, and the relative amounts of retinyl esters were significantly lower than normal.
(8) The specific activities of REH and ARAT were not affected by ZD.
(9) Ethanol ingestion decreased REH (P = 0.0001) and ARAT activities (P = 0.02) and increased cytochrome P-450 (P = 0.04) but had no effect on the activity of ADH in either age group.
(10) The enzymes studied were retinyl ester hydrolase (REH) and microsomal acyl coenzyme A:retinol acyl transferase (ARAT), the principal enzymes regulating retinyl ester hydrolysis and synthesis.
(11) We have assayed ARAT activity in duodenal mucosal homogenate from children with CF.
(12) Thus, when substrate was near or below Km, retinol esterification occurred predominantly by LRAT in the liver and ARAT in the mammary gland, respectively.
(13) ARAT catalyzed the synthesis of retinyl laurate when free retinol and lauroyl-CoA were provided as substrates.
(14) All three mutants were also determined to be resistant to the nucleotide analogs (S)-1-[(3-hydroxy-2- phosphonylmethoxy)propyl]adenine (HPMPA) and (S)-1-[(3-hydroxy-2-phosphonylmethoxy)propyl]cytosine (HPMPC) and hypersensitive to thymine-1-D-arabinofuranoside (AraT).
(15) Hepatic microsomal cytochrome P-450, retinyl ester hydrolase (REH) and cellular retinol-binding protein (cRBP) were significantly reduced; acyl coenzyme A: retinol acyltransferase (ARAT) was increased; and alcohol (retinol) dehydrogenase (ADH) activity was unchanged with age.
(16) The UVB- and retinol-induced ARAT activity was less dependent on exogenous palmitoyl-CoA than that of control microsomes and experiments indicated that this might be due to an increased endogenous concentration of long-chain acyl-CoA in the microsomes.
(17) Experiments with competitive and noncompetitive inhibitors of [3H]retinol esterification established that the epidermal enzyme was an acyl-CoA:retinol acyltransferase (ARAT; EC 2.3.1.76).
(18) The inhibition of ARAT by retinoic acid may be of importance for normal retinol absorption in patients receiving retinoid therapy.
(19) Additions of purine or pyrimidine arabinosides (araT, araC, and araA) to all cell lines resulted in a similar cytotoxicity, suggesting the anabolism of dTTP was not defective in the tr5 clone.
(20) Since the lacrimal gland contains stores of retinyl esters, it was the goal of this study to determine whether the lacrimal gland contains ARAT activity.
Ration
Definition:
(n.) A fixed daily allowance of provisions assigned to a soldier in the army, or a sailor in the navy, for his subsistence.
(n.) Hence, a certain portion or fixed amount dealt out; an allowance; an allotment.
(v. t.) To supply with rations, as a regiment.
Example Sentences:
(1) Our data suggest that a rational use of surveillance cultures and serological tests may aid in an earlier diagnosis of FI in BMT patients.
(2) Consensual but rationally weak criteria devised to extract inferences of causality from such results confirm the generic inadequacy of epidemiology in this area, and are unable to provide definitive scientific support to the perceived mandate for public health action.
(3) We are the generation who saw the war,, who ate bread received with ration cards.
(4) The yeasts amounts used did not protect the test animals from the kidney infiltration with lipids and cholesterol; 12 g of yeasts per 100 g of the ration promoted elevation of sialic acid content in the blood plasma.
(5) Spontaneous reports of suspected adverse reactions may be the only way of revealing very rare events but they present great difficulties of rational interpretation.
(6) The rational surgical methods of treatment in 85 patients with suppurative hepatic echinococcosis penetrating into the abdomen cavity are presented.
(7) Knowledge of these lesions could form the basis for establishing a useful and rational therapy for such cases.
(8) It seams rational to proceed to an earlier total correction in these cases when well defined criteria are fullfilled, as the mortality figures of the palliative and corrective procedures have a tendency to reach each other: (3,2 versus 5,7%).
(9) --The influence of the digestibility of the energy in the ration on the energetic retention effect of BFC is small.
(10) The length of delay is determined by unconscious, non-rational processes, and other factors beyond her control.
(11) But it can be a more rational and better developed approach to long-term care based on the experience and knowledge we have gained in the past 50 years.
(12) The authors further show how test results can be used rationally by clinicians by so-called threshold analysis.
(13) The aetiology remains at present uncertain and therefore rational therapeutic strategies are difficult to plan.
(14) The origin of these substances is unknown, but these findings provide a rational basis for trials of benzodiazepine-receptor antagonists in the management of this disorder.
(15) We reviewed our experience with 245 thyroidectomies to define the spectrum of hypocalcemia, elucidate the mechanisms of hypocalcemia, and formulate a rational basis for its management.
(16) The data obtained can be useful when choosing a rational method for the therapy of gastric scretory disorders.
(17) Willie Spies, its legal representative, said: "Rationality has to return to the debate.
(18) A 35-kg Duroc pig died 3 days after eating a ration containing aflatoxin B1, B2, G1, and G2.
(19) In a Europe (including Britain) where austerity has become the economic dogma of the elite in spite of massive evidence that it is choking growth and worsening the very sickness it claims to heal, there are plenty of rational, sensible arguments for taking to the streets.
(20) The resolution of the cellular events which underlie the development of pancreatitis in combination with the introduction of new therapeutic agents may enable a rational and safe protocol to be developed for the support of patients with pancreatitis.