What's the difference between aromatic and asarone?
Aromatic
Definition:
(a.) Alt. of Aromatical
(n.) A plant, drug, or medicine, characterized by a fragrant smell, and usually by a warm, pungent taste, as ginger, cinnamon, spices.
Example Sentences:
(1) In granulosa cells containing full aromatase activity, treatment with cortisol and dexamethasone did not inhibit aromatization of androstenedione to estrogens whereas two known aromatase inhibitors (dihydrotestosterone and 4-androstene-3, 6, 17-trione) were effective.
(2) The chemical shift changes observed on the binding of trimethoprim to dihydrofolate reductase are interpreted in terms of the ring-current shift contributions from the two aromatic rings of trimethoprim and from that of phenylalanine-30.
(3) Enzyme-inhibiting ability for individual alkylphenols can be estimated based on the quantitative structure-activity relationship developed by Dewhirst (1980) and is a function of the free hydroxyl group, electron-donating ring substituents, and hydrophobic aromatic ring substituents.
(4) N-heterocyclic aromatics are environmentally important carcinogenic pollutants produced by incomplete combustion of organic material.
(5) Deviations from isotropic motion observed for the non-aromatic moieties are discussed.
(6) Aromatic adducts present in the digest that were resistant to nuclease P1 were thus 32P-labelled while unmodified nucleotides were not.
(7) The possible occupational cause of the disease, as more solvents in the mud have the structure of aromatic hydrocarbons is discussed.
(8) Interaction between aromatic diamidines (pentamidine, propamidine, and stilbamidine) and nucleic acids were studied to elucidate the mechanism underlying renal toxicity included by pentamidine in patients.
(9) The D-Phe peptides, which are cleaved especially rapidly by thrombin in water, have structures (in deuterated DMSO) in which the aromatic ring of the D-Phe residue is folded back over the Val or Pip residue.
(10) Results of enzyme immunoassay also showed that dipeptides composed of two aromatic amino acids were more inhibitory than dipeptides of which one residue was aromatic amino acid.
(11) The enzyme has a significant preference for substrates with a P1 Phe over those with the other aromatic amino acids Tyr and Trp.
(12) Their absorption spectra are at sufficiently long wavelength to be unobscured by cellular chromophores such as nucleotides and aromatic amin acids.
(13) As experimental findings indicated inhibitory action of aromatic retinoid on microtubule polymerisation and collagen metabolism of mesenchymal cells, we decided to treat 5 patients suffering from progressive systemic sclerosis as well as 3 patients with Sharp's syndrome with aromatic retinoid (Tigason).
(14) The results also demonstrated that there was not any apparent correlation between the receptor-binding avidities and in vitro monooxygenase enzyme-induction potencies for the most active polynuclear aromatic hydrocarbons.
(15) The complexes are produced by attachment of a carbon of the butenolide ring to an aromatic carbon of the nitro compound with formation of a charge-delocalized cyclohexadienate anion.
(16) Aromatization of [3H]androstenedione and [3H]19-hydroxyandrostenedione to [3H]estrone has been demonstrated to occur in one to two week old primary monolayer cultures of fetal rat hypothalamus.
(17) Both main-stream and side-stream cigarette smoke condensates and some fractions, containing water-soluble bases, water-insoluble bases, and polycyclic aromatic hydrocarbons, were found to induce AHH activity in lung and liver, the lung being induced to the greatest extent.
(18) The greater frequency of dysovulation in obese women, notably those who put on weight rapidly, is accompanied by numerous hormonal changes, including reduced sex hormone-binding globulin, increased ovarian and adrenal androgen production, increased peripheral aromatization of androgens to oestrogens, and altered gonadotropin pulsatile secretion.
(19) R-(+)-Nicotine is a substrate Km = 1.42 X 10(-5)M for an SAM-dependent guinea pig lung aromatic azaheterocycle N-methyltransferase, whereas S-(-)-nicotine acts as a competitive inhibitor (Ki = 6.25 X 10(-5)M) of the N-methylation of its antipode.
(20) In the group of patients with the hyperkinetic form the most significant changes were seen for valine, methionine, serine, alanine and cystine, while as the spectrum of aminoacids of the aromatic line is practically unchanged.
Asarone
Definition:
(n.) A crystallized substance, resembling camphor, obtained from the Asarum Europaeum; -- called also camphor of asarum.
Example Sentences:
(1) Up to 0.1 mL of plasma containing asarone was deproteinated by acetonitrile, which contained an internal standard (indomethacin).
(2) A simple and sensitive high-performance liquid chromatography (HPLC) method for the determination of asarone in rabbit plasma has been developed.
(3) This technique has already found wide application in medical and environmental fields, and some examples of its application to alcoholic beverages are given: detection and determination of possible contaminants, such as phthalate, esters residual monomers from plastic materials (styrene, vinyl chloride), and traces of pesticides; determination of certain non-volatile compounds in wines; and the selective determination of certain compounds for which levels in finished products are limited such as the thujones, safrole, beta-asarone, and coumarine.
(4) In its pharmacological properties the studied asarone is identical with asarone obtained from Acorus calamus and Guatteria.
(5) The extract exhibited a large number of actions similar to alpha-asarone (an active principle of A. calamus) but differed from the latter in several other respects including the responses to electroshock, apomorphine- and isolation-induced aggressive behaviour, amphetamine toxicity in aggregated mice, behavioural despair syndrome in forced swimming, etc.
(6) Furthermore, precocene II (6,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran), a cyclic propenylic plant metabolite and asarone analogue, showed strong hepatocarcinogenic activity similar to that of 1'-hydroxy-2',3'-dehydroestragole and 1'-hydroxy-2',3'-dehydrosafrole; precocene I (the 7-methoxy analogue of precocene II) was less active than precocene II but more active than cis-asarone.
(7) Wine samples containing beta-asarone (cis-2,4,5-trimethoxy-l-propenylbenzene) are distilled; beta-asarone is extracted by hexane and then quantitatively determined by gas-liquid chromatography (GLC), using ethyl palmitate as the internal standard.
(8) The plasma disposition at each dose fitted well to a two-compartment open model and the terminal disposition became much slower as the dose was increased, suggesting a nonlinear dose-dependent plasma asarone disposition.
(9) It was applied to pharmacokinetic studies of asarone in rabbit, after 5, 10, or 20 mg kg-1 intravenous administration.
(10) In contrast, the propenylic derivatives cis- and trans-asarone (1-propenyl-2,4,5-trimethoxybenzene) were each active; the hepatocarcinogenicities of the asarones were not inhibited by prior administration of pentachlorophenol, a sulfotransferase inhibitor that abolished the hepatocarcinogenicity of estragole under the same conditions.
(11) The effect of alpha-asarone, a chemical with hypocholesterolemic properties extracted from Guatteria gaumeri, on SCE induction was studied both in human lymphocytes in vitro and in murine bone marrow cells in vivo.
(12) In acute and chronic experiments on mice, rats, cats and rabbits in a wide range of tests, a study was conducted of the biological properties of alpha-asarone (1-propenyl-2,4,5- methoxybenzol)--etherophenol, isolated by the authors from the roots of Asarum europaeum.
(13) The ultraviolet spectra of beta-asarone and its isomer were also determined.
(14) The gas-liquid chromatographic determination of beta-asarone (cis-2,4,5-trimethyoxy-1-propenylbenzene) in wine was collaboratively studied by 9 analysts.
(15) The embryotoxicity and teratogenicity of alpha-asarone were investigated in mice.
(16) Mass spectrometry confirmed the identity of the GLC peak as beta-asarone.
(17) From the ethyl acetate extract of Asarum forbesii Maxin, four new constituents, asarumin A(I), B(II), C(III) and D(IV), were isolated along with elemicin (V), trans-asarone(VI) and linoleic acid(VII).