(1) Dietary fat can modify the vulnerability of the myocardium to arrhythmic stimuli.
(2) The arrhythmic threshold dose for epinephrine and dopamine was significantly (p less than 0.05) reduced during halothane anesthesia when compared to values determined in awake animals.
(3) These unfortunate results were especially surprising in that the CAST population represented patients in whom the risk of arrhythmic death was only moderate and the risk of proarrhythmia was thought to be low.
(4) The arrhythmic action on the ventricle is therefore remarkable and is not accompanied by patent electrophysiologic effects.
(5) Clofilium and d-sotalol differentially produced early afterdepolarisations at or very near "anti-arrhythmic" doses.
(6) The sensitivity of the signal-averaged ECG as a predictor of arrhythmic events was 92% with a specificity of 62%.
(7) Although an effective therapeutic regimen can generally be achieved with no exact knowledge of the arrhythmic mechanism or of the specific action of a given drug, future investigations hould augment existing information to yield a more rational means of treatment and prevention of arrhythmias as well as to aid in the development of new antiarrhythmic agents.
(8) Since LPG have pronounced arrhythmogenic properties, the data obtained suggest that anti-arrhythmic activity of phosphocreatine and phosphocreatinine in acute myocardial ischemia results from the effect these substances have on membrane phospholipid metabolism in the ischemized area.
(9) At the experiments with the isolated rat hearts, prepared by Langendorff, the anti-arrhythmic dose-effects of the water-soluble antioxidant fenozan from the class of steric-hindrance phenols were studied at condition of regional ischemia and reperfusion, as well as its action on the coronary flow.
(10) Although all anticholinergics exert an arrhythmic effect, comparative data on occurrence and severity of arrhythmias are not available.
(11) In the presence of papaverine isoprenaline induced arrhythmic contractions of the papillary muscle: the incidence of arrhythmic contractions was positively correlated to the concentration of papaverine.
(12) In view of the results of CAST, researchers working in the field of experimental arrhythmia have been increasingly focusing on the quest for new anti-arrhythmic modes of action and ways of detecting pro-arrhythmic properties of antiarrhythmic drugs at an early stage.
(13) Actuarial analysis has demonstrated significant impact on the survival rate of the patients receiving implants with 1 year arrhythmic mortality rate reduced to 2% or less in all groups analyzed.
(14) The antiarrhythmic effect of sodium valproate (acidoprol) on the degree of arrhythmic manifestations was examined in 18 patients with neurocirculatory dystonia (NCD) and 19 with coronary heart disease (CHD).
(15) Even though the overall mortality rate was 13.20%, it was not due to arrhythmia itself but most of them died of non-arrhythmic origin.
(16) Left ventricular end-diastolic cavity dimensions were smaller in those with an abnormal forearm blood flow response, but other clinical, echocardiographic, and arrhythmic variables were similar.
(17) In arrhythmic cases, lithium oxybutyrate was shown to have a hypokinetic effect on central hemodynamics and contribute to peripheral vasodilatation without causing clinically apparent circulatory disorders.
(18) We wanted to know whether the arrhythmicity of this population was due to the absence of circadian rhythmicity within each individual cell, or merely due to asynchrony of a population of individually rhythmic cells.
(19) As intensive care evolved, better resuscitation techniques became available, understanding of the terminal arrhythmic mechanism improved, and the prevention of cardiac arrest by aggressive and prompt treatment of the minor warning arrhythmias became feasible.
(20) This pro-arrhythmic effect appears to be related to its class 3 anti-arrhythmic properties (QT interval prolongation) which is dose dependent, occurring only at large doses.