(1) The operon was found to have two functional regions, the promoter-proximal region encoding resistance to arsenite and antimonate and the promoter-distal region encoding arsenate resistance.
(2) At the same time, arsenate stabilizes the delta psi value, but blocks K+ uptake.
(3) Because of the analogous results with arsenate and sulfate, it is suggested that arsenate, like sulfate, may enhance the carcinogenicity of other carcinogens.
(4) The levels of arsenobetaine, which occurs naturally in these fish, did not appear to be affected by the oral dosing with sodium arsenate.
(5) Experiments with both types of cells showed a direct correlation between the arsenate taken up and the amount of As-lipid complex formed.
(6) Pretreatment of the cells with respiratory chain poisons or uncouplers, except for arsenate, inhibited transport up to 95%.
(7) In the presence of phosphate, arsenate uptake is inhibited while in the presence of arsenate, phosphate uptake is only slightly inhibited.
(8) The resistance pattern included arsenate, arsenite, and antimonate ions.
(9) First-time measurements of the potentially toxic inorganic species of arsenic (arsenite and arsenate) have been obtained in fine (less than 2.5 microns AD) and coarse (greater than 2.5 microns AD) atmospheric particles in the Los Angeles area.
(10) The effects of the metabolic inhibitors, arsenate (1,10 mM), iodoacetate (1 mM), alpha-cyano-4-hydroxycinnamate (alpha C4HC: 0.05, 0.15, 0.5 mM), malonate (10 mM) and 2,4-dinitrophenol (10 microM) on granule cell evoked activity and levels of energy metabolites of superfused hippocampal slices were investigated.
(11) Hamster dams were exposed to teratogenic doses of arsenate by means of osmotic minipumps implanted on the morning of Day 6 of the gestation period.
(12) These results suggest that, in the presence of MgADP, vanadate or arsenate, and 3-P-glycerate, the enzyme catalyzed the formation of multiple structurally distinguishable complexes that are stable on the enzyme and labile off the enzyme.
(13) Post mortem reduction of arsenate to arsenite was found to occur rapidly in fish tissue.
(14) The inhibition constants for arsenate and for glycerol phosphate with the mutant enzyme are similar to those with the wild-type isomerase, but the substrate analogues 2-phosphoglycolate and phosphoglycolohydroxamate bind 8- and 35-fold, respectively, more weakly to the mutant isomerase.
(15) Arsenate seems to bind with similar affinity, but with distinctly less protective activity (maximum of 16%).
(16) Inactivation of the high-affinity component evidently requires the utilization of a fermentable substrate by the cells, since inactivation did not occur during carbon starvation, when a fermentable sugar was added to starved cells, inactivation began, when the fermentation inhibitors iodoacetate or arsenate were added in addition to sugars, the inactivation was prevented, when a non-fermentable substrate was added instead of sugars, inactivation was also prevented.
(17) A delay in the rise to the maximum rate of 86Rb release upon stimulation with arsenate is shown to be due to the time required for arsenylation, and from an analysis of the rise and fall of the rate of 86Rb release the rate constants for arsenylation and dearsenylation at pH 7.2 can be estimated; the decay in the rate of 86Rb release when arsenate or phosphate is removed from the solution provides a second method for determination of the dearsenylation rate.
(18) We determined the concentration and chemical status of arsenic in the placentas of hamsters following continuous exposure via the osmotic minipump to minimally and frankly teratogenic doses of arsenate.
(19) The developmental origin of arsenate-induced renal agenesis was investigated.
(20) Cell swelling induced by tetanolysin was much lower with energy-depleted M. gallisepticum cells, with arsenate-treated cells, or when the membrane potential (delta psi) was collapsed by valinomycin (10 microM) plus KCl (100 mM).
Arsenic
Definition:
(n.) One of the elements, a solid substance resembling a metal in its physical properties, but in its chemical relations ranking with the nonmetals. It is of a steel-gray color and brilliant luster, though usually dull from tarnish. It is very brittle, and sublimes at 356¡ Fahrenheit. It is sometimes found native, but usually combined with silver, cobalt, nickel, iron, antimony, or sulphur. Orpiment and realgar are two of its sulphur compounds, the first of which is the true arsenicum of the ancients. The element and its compounds are active poisons. Specific gravity from 5.7 to 5.9. Atomic weight 75. Symbol As.
(n.) Arsenious oxide or arsenious anhydride; -- called also arsenious acid, white arsenic, and ratsbane.
(a.) Pertaining to, or derived from, arsenic; -- said of those compounds of arsenic in which this element has its highest equivalence; as, arsenic acid.
Example Sentences:
(1) Each group was further divided into two groups; one was given the diet containing 100ppm of arsenic trioxide and the other a diet containing "arsenic compound" (100ppm as arsenic trioxide).
(2) An acute massive epidemic of arsenic poisoning in Argentina involved 718 subjects.
(3) However, there was unequivocal chronic arsenic intoxication.
(4) ARSENIC is a computerized system providing assistance for telephone consultation in poison centers.
(5) The concentrations of arsenic (As) and gallium (Ga) in solution and the As-GA ratio on the surface of the GaAs increased continuously as the time of contact with the aqueous solution increased.
(6) We studied the role of S-adenosylmethionine (SAM) as a methyl group donor in the methylation of inorganic arsenic in mammalians.
(7) The second tool is trivalent arsenical affinity chromatography, which we use to show novel direct interactions between trivalent arsenicals and several proteins from 3T3-L1 adipocytes including the insulin-responsive glucose transporter GLUT4, the insulin proreceptor, and both the alpha and beta subunits of tubulin.
(8) For both children and adults, the arsenic values were similar to those in a limited Danish reference population.
(9) This seems to be the first experimental confirmation of carcinogenicity of arsenic-containing pesticides used formerly in vineyards.
(10) Genotoxic evaluations of arsenic trioxide, dieldrin, lead tetraacetate and their nine binary and one tertiary mixtures were performed using the Tradescantia micronucleus (Trad-MN) assay.
(11) On the other hand, the major arsenic compound in fish, crustacea and molluscs has been identified as arsenobetaine, which is an arseno-analog of glycinebetaine, a very common osmo-regulator in living organisms.
(12) This study suggests that the much greater induction of morphological alterations, such as increased heterochromatin, in lung endothelial nuclei than in the liver might explain the high risk of lung cancer by arsenics, and that there may be a close relationship between heterochromatin alteration and DNA damages.
(13) Arsenic moves in a dispersive manner through air and water and is in physical and chemical equilibrium in many substrates.
(14) First-time measurements of the potentially toxic inorganic species of arsenic (arsenite and arsenate) have been obtained in fine (less than 2.5 microns AD) and coarse (greater than 2.5 microns AD) atmospheric particles in the Los Angeles area.
(15) Among various miscellaneous inhibitors, quercetin, disulfiram, and the Ca-complexing agents arsenazo I and III showed marked activity, the latter exclusively on the arsenical-resistant T. brucei.
(16) The patient has a history of occupational exposure to arsenic 42 years before.
(17) Meanwhile, the excess of respiratory cancers alone will continue to increase 5% for each microgram of arsenic present per m3 of air breathed in the work area, or excreted in every one-third liter of urine.
(18) Brazil dam burst: BHP boss to inspect disaster zone with dozens still missing Read more Brazil’s national water agency, ANA, has warned that the presence of arsenic, zinc, copper and mercury now present in the Rio Doce make the water untreatable for human consumption.
(19) When crab meat was ingested, none of these four arsenic species were observed at elevated levels until the urine was heated in 2N NaOH.
(20) The occurrence of chromosome aberrations was studied in short-term cultured lymphocytes from nine workers exposed to arsenic at the Rönnskär smeltery in northern Sweden.