(v. t.) To render (a person) certain; to cause to feel certain; to make confident; to assure; to apprise.
(v. t.) To make (a thing) certain to the mind; to free from obscurity, doubt, or change; to make sure of; to fix; to determine.
(v. t.) To find out or learn for a certainty, by trial, examination, or experiment; to get to know; as, to ascertain the weight of a commodity, or the purity of a metal.
Example Sentences:
(1) We have investigated the effect of methimazole (MMI) on cell-mediated immunity and ascertained the mechanisms of immunosuppression produced by the drug.
(2) Prior to oral feeding, little or no ELA was detected in stools and endotoxinemia was ascertained in only six of 45 infants (13%).
(3) A total of 13 ascertainments of folate sensitive autosomal fragile sites is observed, of which 10q23 fragility appears to be the most frequent.
(4) A similar examination of the effects of PD was also carried out in vitro to ascertain whether PD itself or its metabolites are involved in its action.
(5) The purity and configuration of each isomer of the free acid and N-chloroacetylated derivative were ascertained by: (a) paper chromatography in five solvent systems, (b) elemental analysis, (c) Van Slyke nitrous acid determination of alpha-carbonyl carbon, and (d) Van Slyke ninhydrin determination of alpha-carbonyl carbon, and (e) optical rotation.
(6) In an anthropologic study of illness referral among Latin-American immigrants three phases were ascertained: First, there was extended use of self-treatment.
(7) In 20 adult patients with asthma, we evaluated bronchodilation to a single administration of metered-dose glycopyrrolate aerosol (GA) to ascertain its onset and duration of action along with evaluation of safety.
(8) 64% of the patients without nodular metastases and 45% of the patients with histologically ascertained nodular metastases and 45% of the patients with histologically ascertained nodular metastases survived the 3-year interval.
(9) The results indicated a very good comparability between the dot-blot assay and IF-tests, and this dot-blot method was ascertained as a simple and useful method for the scrub typhus serodiagnosis.
(10) Combinations of YM534 with other anti-cancer agents were examined to ascertain whether YM534 potentiated other anti-cancer agents against the KB cell line and its multidrug-resistant counterpart, VJ-300.
(11) Three experiments in person perception were conducted to investigate the conditions under which naive observers label an actor as aggressive and to ascertain how this label affects the reactions of the observers to the actor.
(12) This study was designed to ascertain the frequency of these problems in our RS patients, whether they were related to other clinical features of RS and what was the extent of the resulting disability.
(13) The nutritional requirements for optimal production of biologically active l-asparaginase by a strain of Escherichia coli have been ascertained.
(14) Fifty-seven strains of enterotoxigenic Escherichia coli isolated from humans and pigs and producing thermolabile (LT) enterotoxin were used to ascertain the efficiency of the Biken test compared to the passive immune haemolysis test (PIH), considered as very sensitive for detecting that enterotoxin.
(15) In the formation of the transformation index the difference between the two groups could be statistically ascertained.
(16) This was a highly significant (p less than 0.0001) predictor of 5-year total mortality, whose ascertainment was virtually complete.
(17) On the basis of segregating phenotypes, the genetic potentials of these compatible nocardiae were ascertained as follows: the formation of a diploid with subsequent segregation of parental or haploid recombinant genomes or both; persistence of the diploid through many generations; continuing reassortment of genetic information by multiple matings between parental or recombinant organisms; and, very probably, second-round recombinations within the diploid.
(18) Based on the ratio of plasma membrane marker enzyme activity determined in the nuclear preparation, the purity of the isolated nuclei was ascertained.
(19) The amount of free testosterone in the saliva was also ascertained for 23 of the subjects.
(20) In addition, re-analysis of previous investigations of the MAB underscores the importance of ascertaining the reading level of subjects prior to the administration of the MAB.
Exacerbate
Definition:
(v. t.) To render more violent or bitter; to irriate; to exasperate; to imbitter, as passions or disease.
Example Sentences:
(1) Circuit weight training does not exacerbate resting or exercise blood pressure and may have beneficial effects.
(2) In patients with acute exacerbations of chronic obstructive pulmonary disease, although either sympathomimetic or anticholinergic therapy provides bronchodilatation, no further benefit could be demonstrated from combination therapy.
(3) We report a case of chronic recurrent polymyositis associated with increasing antibody titers of coxsackievirus A9 in serum during clinical exacerbations.
(4) The data indicate that activated helper T cells are required and sufficient to give rise to the inflammatory infiltrates that are characteristic of the inflammations and exacerbations in human rheumatoid arthritis.
(5) The development of renal insufficiency during enalapril therapy may be exacerbated by concomitant diuretic therapy and should raise the suspicion of underlying transplant renal-artery stenosis.
(6) A lysosomal membrane labilizer, vitamin A, exacerbated the cartilage pathology, whereas a stabilizer, cortisone, retarded it.
(7) The utility of a life charting approach is emphasized in delineating past and present course of illness, considering the relevance of cycling pattern and past treatment efficacy in selection of present pharmacological interventions, and helping to formulate a multifactorial concept of the interplay of biological and psychosocial factors in the evolution or exacerbation of mood disorders.
(8) Endotoxins in plasma were monitored during treatment in 18 patients hospitalised for acute exacerbation of Crohn's disease: systemic endotoxaemia was found on admission in all but one.
(9) Exacerbation of inflammation due to repeated traumatization of the oesophagus wall was accompanied by proliferation of the epithelial layers.
(10) Pyoderma gangrenosum is a poorly understood disease characterized by exacerbations and remissions of morphologically unique skin ulcers.
(11) A complex scheme of prophylaxis of exacerbation and progression of chronic bronchopulmonary diseases in children was developed.
(12) The clinical aspects with remission and exacerbation are discussed.
(13) We designed the present study to evaluate the efficacy and safety of cefaclor in the treatment of acute exacerbations of chronic bronchitis in cigarette smokers.
(14) It was demonstrated that neither enflurane nor halothane exacerbates a pre-existing susceptibility to seizure activity and that both these inhalation anaesthetics are suitable for cases suffering from cerebral convulsive disorders.
(15) We conclude that myoglobinuria, of a degree insufficient to cause renal failure itself, can interact with renal ischemia to significantly exacerbate the renal damage produced.
(16) These lymph node reactions could have likely been a part of the so called early exacerbation.
(17) Hyperglycemia exacerbates neurologic damage in clinical and experimental central nervous system ischemia.
(18) Anticoagulation may exacerbate possible tendencies for an ischemic infarction to become hemorrhagic.
(19) (4) Symptoms are exacerbated by a research ward that is disruptive to the community.
(20) This injury was exacerbated to grade 4 (p less than 0.05) following reperfusion but was almost completely healed 24 h later.