(1) The presence of proteins antigenically related to Bothrops asper myotoxins in various snake venoms, mainly from South America, was investigated by using polyclonal and monoclonal antibodies.
(2) The myotoxin shows partial immunologic identity with a myotoxic phospholipase A2 isolated from Bothrops asper venom.
(3) Mice that received antivenom (0.4 ml) by the iv or im route 15 min after im injection of B. asper venom (100 micrograms) had lower levels of plasma anti-myotoxin antibodies than controls injected with antivenom only, suggesting that at least a fraction of the antibodies combines with myotoxins in vivo.
(4) Metalloproteinase from the venom of Bothrops asper (proteinase G) is a glycoprotein with 1% neutral hexose and 3.5 moles of sialic acid per mole of protein.
(5) A new instrumentation for posterior spinal surgery consists of metallic rods carved with diamond-shaped asperities on which vertebral hooks or screws can be screwed in any position, level, or degree of rotation.
(6) Conditions that inhibited phospholipase A2 activity, i.e., substitution of calcium by EDTA, reduced liposome-disrupting activity of Bothrops asper myotoxin I and Bothrops atrox myotoxin, both of which have high phospholipase A2 activity, but did not affect the action of B. asper myotoxin II and Bothrops moojeni myotoxin II, which have extremely low phospholipase A2 activity.
(7) The time-course and composition of inflammatory infiltrate in mouse gastrocnemius injected with Bothrops asper venom was studied.
(8) Also, the organization of these asperities is directly related to cellular cytoskeletal elements.
(9) The neutralization of two myotoxic phospholipases A2 from the venom of Bothrops asper, myotoxins I and II, by two murine monoclonal antibodies is reported.
(10) Seventeen batches of ICP antivenom were analyzed by EIA, using B. asper myotoxin II as antigen.
(11) No major differences in the DNase electrophoretic pattern were observed between individual venoms of adult B. asper specimens nor between lyophilized and frozen venoms.
(12) It is suggested that muscle regeneration is partially impaired after myonecrosis induced by Bothrops asper venom, probably due to the damage induced by this venom on muscle microvasculature and nerves.
(13) He used fine needle asperation or scraping of pathological tissue and hematoxylin-eosin staining of smears.
(14) Immunochemical results indicate a close immunological relationship between venoms of B. asper, B. nummifer and C. d. durissus collected in Honduras and Guatemala with those of the same species collected in Costa Rica.
(15) A new muscle damaging toxin, myotoxin II, was purified from the venom of Bothrops asper by ion-exchange chromatography on CM-Sephadex C-25.
(16) Ouchterlony immunodiffusion analysis of purified antibodies showed two precipitation bands with a pattern of complete immunologic identity between samples of crude B. asper venoms from specimens collected in the Atlantic and Pacific regions of Costa Rica.
(17) Myotoxin is an abundant component in adult B. asper venom.
(18) Five polyvalent antivenoms (Crotalidae; Orient, North, Central and South Africa) were tested for their ability to neutralize the thrombin-like activity of snake venoms (Bitis gabonica, Agkistrodon acutus, Bothrops asper, B. atrox, Crotalus adamanteus).
(19) A myotoxic, basic phospholipase A2 (pI greater than 9.5) with anticoagulant activity has been purified from the venom of Bothrops asper, and its amino acid sequence determined by automated Edman degradation.
(20) The effects of a myotoxic phospholipase A2 isolated from the venom of the crotaline snake Bothrops asper on skeletal muscle myofibrils were studied by histological, ultrastructural, immunohistochemical, and biochemical parameters.
Harsh
Definition:
(a.) Rough; disagreeable; grating
(a.) disagreeable to the touch.
(a.) disagreeable to the taste.
(a.) disagreeable to the ear.
(a.) Unpleasant and repulsive to the sensibilities; austere; crabbed; morose; abusive; abusive; severe; rough.
(a.) Having violent contrasts of color, or of light and shade; lacking in harmony.
Example Sentences:
(1) Federal judges who blocked the bans cited harsh rhetoric employed by Trump on the campaign trail , specifically a pledge to ban all Muslims from entering the US and support for giving priority to Christian refugees, as being reflective of the intent behind his travel ban.
(2) The first problem facing Calderdale is sheep-rustling Happy Valley – filmed around Hebden Bridge, with its beautiful stone houses straight off the pages of the Guardian’s Lets Move To – may be filled with rolling hills and verdant pastures, but the reality of rural issues are harsh.
(3) On referral to our clinic, his physical examination and tape recording were characterized by harsh inspiratory stridor.
(4) There are harsh lessons in football and we have learned some over the last week.” Two James Milner penalties and goals from the impressive Adam Lallana, Sadio Mané and Philippe Coutinho took Liverpool’s tally to 24 in eight games.
(5) The tougher external environment in 2015 means that our businesses and functions need to work … to take a number of measures in response to the harsh trading environment,” Dudley said, according to a memo reported by Reuters.
(6) I couldn't shake the harsh words from my head and worried about if, or when, they would spill over into real life.
(7) A former senior CIA official said the secretary of state at the time, Colin Powell, eventually was informed about the program and sat in meetings in which harsh interrogation techniques were discussed.
(8) The results indicate the presence of carbohydrate epitopes buried within collagenous polypeptides that are exposed by harsh denaturing conditions.
(9) Official papers released by the National Archives show that the "wets" – notably Jim Prior, Peter Walker, Ian Gilmour, Mark Carlisle, Lord Soames and Francis Pym – were able to demonstrate that a majority of the cabinet rejected as unnecessarily harsh Sir Geoffrey Howe's demands for further public spending cuts and tax cuts.
(10) We report a case of a 17 year old boy who was referred for evaluation of a large anterior mediastinal mass, causing dyspnea and cough and resulting in a harsh systolic murmur.
(11) I appeal to the king of Saudi Arabia to exercise his power to halt the public flogging by pardoning Mr Badawi, and to urgently review this type of extraordinarily harsh penalty.” Badawi’s case was one of several recent prosecutions of activists.
(12) • Very robust questioning, known as the harsh approach, could be banned – or if not "the approach should not include an analogy with a military drill sergeant".
(13) He said he did not oppose the criminalisation of homosexuality but said imprisonment and the death penalty are too harsh.
(14) Fellow opposition activists and sympathisers took the harsh sentence as a sign that heavy jail terms awaited the rest.
(15) Pledge news: harsh • 26 Jan , Darragh MacAnthony, Peterborough chairman on the "incredibly harsh" abuse by fans of manager Mark Cooper: "Nobody has given the bloke a chance.
(16) But initial fan reaction to the first teaser trailers was harsh.
(17) The probability of skin-galvanic reaction appearance was harshly decreased.
(18) Offshore detention with increased isolation in remote and harsh circumstances exaggerates that adversity.
(19) Pictures of the concentration camps served to reinforce the necessity of the war and its unavoidably harsh economic legacy.
(20) If you're in doubt of the impact this can have, "brand imagery" studies show that when participants smoke the exact same cigarettes presented in lighter coloured packs, or in packs with "mild" in the name, they rate the smoke as lighter and less harsh, simply through the power of suggestion.