(n.) Roughness of surface; unevenness; -- opposed to smoothness.
(n.) Roughness or harshness of sound; that quality which grates upon the ear; raucity.
(n.) Roughness to the taste; sourness; tartness.
(n.) Moral roughness; roughness of manner; severity; crabbedness; harshness; -- opposed to mildness.
(n.) Sharpness; disagreeableness; difficulty.
Example Sentences:
(1) The presence of proteins antigenically related to Bothrops asper myotoxins in various snake venoms, mainly from South America, was investigated by using polyclonal and monoclonal antibodies.
(2) The myotoxin shows partial immunologic identity with a myotoxic phospholipase A2 isolated from Bothrops asper venom.
(3) Mice that received antivenom (0.4 ml) by the iv or im route 15 min after im injection of B. asper venom (100 micrograms) had lower levels of plasma anti-myotoxin antibodies than controls injected with antivenom only, suggesting that at least a fraction of the antibodies combines with myotoxins in vivo.
(4) Metalloproteinase from the venom of Bothrops asper (proteinase G) is a glycoprotein with 1% neutral hexose and 3.5 moles of sialic acid per mole of protein.
(5) A new instrumentation for posterior spinal surgery consists of metallic rods carved with diamond-shaped asperities on which vertebral hooks or screws can be screwed in any position, level, or degree of rotation.
(6) Conditions that inhibited phospholipase A2 activity, i.e., substitution of calcium by EDTA, reduced liposome-disrupting activity of Bothrops asper myotoxin I and Bothrops atrox myotoxin, both of which have high phospholipase A2 activity, but did not affect the action of B. asper myotoxin II and Bothrops moojeni myotoxin II, which have extremely low phospholipase A2 activity.
(7) The time-course and composition of inflammatory infiltrate in mouse gastrocnemius injected with Bothrops asper venom was studied.
(8) Also, the organization of these asperities is directly related to cellular cytoskeletal elements.
(9) The neutralization of two myotoxic phospholipases A2 from the venom of Bothrops asper, myotoxins I and II, by two murine monoclonal antibodies is reported.
(10) Seventeen batches of ICP antivenom were analyzed by EIA, using B. asper myotoxin II as antigen.
(11) No major differences in the DNase electrophoretic pattern were observed between individual venoms of adult B. asper specimens nor between lyophilized and frozen venoms.
(12) It is suggested that muscle regeneration is partially impaired after myonecrosis induced by Bothrops asper venom, probably due to the damage induced by this venom on muscle microvasculature and nerves.
(13) He used fine needle asperation or scraping of pathological tissue and hematoxylin-eosin staining of smears.
(14) Immunochemical results indicate a close immunological relationship between venoms of B. asper, B. nummifer and C. d. durissus collected in Honduras and Guatemala with those of the same species collected in Costa Rica.
(15) A new muscle damaging toxin, myotoxin II, was purified from the venom of Bothrops asper by ion-exchange chromatography on CM-Sephadex C-25.
(16) Ouchterlony immunodiffusion analysis of purified antibodies showed two precipitation bands with a pattern of complete immunologic identity between samples of crude B. asper venoms from specimens collected in the Atlantic and Pacific regions of Costa Rica.
(17) Myotoxin is an abundant component in adult B. asper venom.
(18) Five polyvalent antivenoms (Crotalidae; Orient, North, Central and South Africa) were tested for their ability to neutralize the thrombin-like activity of snake venoms (Bitis gabonica, Agkistrodon acutus, Bothrops asper, B. atrox, Crotalus adamanteus).
(19) A myotoxic, basic phospholipase A2 (pI greater than 9.5) with anticoagulant activity has been purified from the venom of Bothrops asper, and its amino acid sequence determined by automated Edman degradation.
(20) The effects of a myotoxic phospholipase A2 isolated from the venom of the crotaline snake Bothrops asper on skeletal muscle myofibrils were studied by histological, ultrastructural, immunohistochemical, and biochemical parameters.
Hardship
Definition:
(n.) That which is hard to hear, as toil, privation, injury, injustice, etc.
Example Sentences:
(1) A failure to reach a solution would potentially leave 200,000 homes without affordable cover, leaving owners unable to sell their properties and potentially exposing them to financial hardship.
(2) The findings provide additional evidence that, for at least some cases, the likelihood of a physician's admitting a patient to the hospital is influenced by the patient's living arrangements, travel time to the physician's office, and the extent to which medical care would cause a financial hardship for the patient.
(3) Actions achieved or a long commitment to an ideal, often through hardship.
(4) The Kremlin has so far refrained from dealing with mounting anger against people from Russia's turbulent North Caucasus region, as well as migrant workers from central Asia, which has grown as the country's oil-fuelled economic boom has given way to the hardship of the global financial crisis.
(5) We don't want to harm ourselves; we don't want suffering; we don't want hardship; we don't accept difficulty and disappointment.
(6) Woman at centre of South Korean row says she 'deserves death' Read more Presidential spokesman Jung Youn-kuk said: “The Blue House named Kim as the right person to lead the cabinet for the country’s future and to overcome current hardships.” Yim Jong-yong, the Financial Services Commission chairman, was named the new finance minister and deputy prime minister.
(7) He also thanked nearly everyone who had been involved in the trial: his attorneys, his family, everyone who testified “with dignity” about their “unbearable” hardships.
(8) There will be a hardship waiver for those individuals who still cannot afford coverage, and 95% of all small businesses, because of their size and narrow profit margin, would be exempt from these requirements.
(9) For Paralympians, training and competition is an escape from the hardships and struggles of their everyday life.
(10) He was only four-years-old then, way too young to understand the hardships of life.
(11) But take back the initiative – because we've seen what happens when we let politicians take sole responsibility for how we organise our society: it's resulted in profound economic failure and material hardship.
(12) When combined with economic hardship, this loss makes the jobless more likely to suffer depression and even to take their own lives, as starkly shown by Sanjay Basu and David Stuckler in The Body Economic .
(13) The intimacy between community members and the doctor's own friendships with families, the distance to specialized services and the hardship travel might cause for patients, the economic risks in treating indigents in an already financially strapped small facility, and the physician's role as a citizen as well as health care provider are factors that cannot be ignored in treatment decisions.
(14) Already, 34 families have been given emergency hardship grants totalling more than £23,000, as the county offers them a lifeline.
(15) Is it hopelessly old fart-ish to hope exposure that to the horrors described by Buergenthal will remind all of us of the piffling nature of our next household conflagration about who gets to wear which pair of jeans, or whether homework on the weekend really constitutes a hardship – or even, somehow, temper the demand for new electronic equipment?
(16) Others argue that younger people are less used to dealing with hardship than their parents' generation and lack the resilience to cope with problems.
(17) I understood why our claims history had come back to bite us but still complained that, in these times of hardship, paying nearly £9 more each month was too much.
(18) Bellows is known for his powerful paintings representing the hardship and desperation and grittiness of life in New York as it emerged in to the 20th century.
(19) Despite years of violence, hardship and bitterly disputed votes, the hopeful mood suggested many feel change is finally within their grasp.
(20) Data on the economic status, number of rooms per household, number of persons per household, type of water supply, and mode of excreta disposal revealed that the majority of the population surveyed lived with economic hardship, overcrowding and poor hygiene.