(1) The presence of proteins antigenically related to Bothrops asper myotoxins in various snake venoms, mainly from South America, was investigated by using polyclonal and monoclonal antibodies.
(2) The myotoxin shows partial immunologic identity with a myotoxic phospholipase A2 isolated from Bothrops asper venom.
(3) Mice that received antivenom (0.4 ml) by the iv or im route 15 min after im injection of B. asper venom (100 micrograms) had lower levels of plasma anti-myotoxin antibodies than controls injected with antivenom only, suggesting that at least a fraction of the antibodies combines with myotoxins in vivo.
(4) Metalloproteinase from the venom of Bothrops asper (proteinase G) is a glycoprotein with 1% neutral hexose and 3.5 moles of sialic acid per mole of protein.
(5) A new instrumentation for posterior spinal surgery consists of metallic rods carved with diamond-shaped asperities on which vertebral hooks or screws can be screwed in any position, level, or degree of rotation.
(6) Conditions that inhibited phospholipase A2 activity, i.e., substitution of calcium by EDTA, reduced liposome-disrupting activity of Bothrops asper myotoxin I and Bothrops atrox myotoxin, both of which have high phospholipase A2 activity, but did not affect the action of B. asper myotoxin II and Bothrops moojeni myotoxin II, which have extremely low phospholipase A2 activity.
(7) The time-course and composition of inflammatory infiltrate in mouse gastrocnemius injected with Bothrops asper venom was studied.
(8) Also, the organization of these asperities is directly related to cellular cytoskeletal elements.
(9) The neutralization of two myotoxic phospholipases A2 from the venom of Bothrops asper, myotoxins I and II, by two murine monoclonal antibodies is reported.
(10) Seventeen batches of ICP antivenom were analyzed by EIA, using B. asper myotoxin II as antigen.
(11) No major differences in the DNase electrophoretic pattern were observed between individual venoms of adult B. asper specimens nor between lyophilized and frozen venoms.
(12) It is suggested that muscle regeneration is partially impaired after myonecrosis induced by Bothrops asper venom, probably due to the damage induced by this venom on muscle microvasculature and nerves.
(13) He used fine needle asperation or scraping of pathological tissue and hematoxylin-eosin staining of smears.
(14) Immunochemical results indicate a close immunological relationship between venoms of B. asper, B. nummifer and C. d. durissus collected in Honduras and Guatemala with those of the same species collected in Costa Rica.
(15) A new muscle damaging toxin, myotoxin II, was purified from the venom of Bothrops asper by ion-exchange chromatography on CM-Sephadex C-25.
(16) Ouchterlony immunodiffusion analysis of purified antibodies showed two precipitation bands with a pattern of complete immunologic identity between samples of crude B. asper venoms from specimens collected in the Atlantic and Pacific regions of Costa Rica.
(17) Myotoxin is an abundant component in adult B. asper venom.
(18) Five polyvalent antivenoms (Crotalidae; Orient, North, Central and South Africa) were tested for their ability to neutralize the thrombin-like activity of snake venoms (Bitis gabonica, Agkistrodon acutus, Bothrops asper, B. atrox, Crotalus adamanteus).
(19) A myotoxic, basic phospholipase A2 (pI greater than 9.5) with anticoagulant activity has been purified from the venom of Bothrops asper, and its amino acid sequence determined by automated Edman degradation.
(20) The effects of a myotoxic phospholipase A2 isolated from the venom of the crotaline snake Bothrops asper on skeletal muscle myofibrils were studied by histological, ultrastructural, immunohistochemical, and biochemical parameters.
Cruel
Definition:
(n.) See Crewel.
(a.) Disposed to give pain to others; willing or pleased to hurt, torment, or afflict; destitute of sympathetic kindness and pity; savage; inhuman; hard-hearted; merciless.
(a.) Causing, or fitted to cause, pain, grief, or misery.
(a.) Attended with cruetly; painful; harsh.
Example Sentences:
(1) China’s new law also restricts the right of media to report on details of terror attacks, including a provision that media and social media cannot report on details of terror activities that might lead to imitation, nor show scenes that are “cruel and inhuman”.
(2) Through small and large acts of deprivation and destruction we follow the process: the removal of hope, of dignity, of luxury, of necessity, of self; the reduction of a man to a hoarder of grey slabs of bread and the scrapings of a soup bowl (wonderfully told all this, with a novelist's gift for detail and sometimes very nearly comic surprise), to the confinement of a narrow bed – in which there is "not even any room to be afraid" – with a stranger who doesn't speak your language, to the cruel illogicality of hating a fellow victim of oppression more than you hate the oppressor himself – one torment following another, and even the bleak comfort of thinking you might have touched rock bottom denied you as, when the most immediate cause of a particular stress comes to an end, "you are grievously amazed to see that another one lies behind; and in reality a whole series of others".
(3) It goes on: "In a reality of ongoing occupation, of solid cynicism and meanness, each and every one of us bears the moral obligation to try to relieve the suffering, do something to bend back the occupation's giant, cruel hand."
(4) At one point, Walters speculates that “she looks the same weight as the Duchess – about 8st”; later, he disingenuously asks her to discuss “the cruel comments about being a ‘childless spinster’”, neither telling readers who made those “cruel comments” in the first place, or where.
(5) More here: UK regulator urges banks to speed up swaps mis-selling compensation 8.40am GMT More reaction to the decision to send riot police to evict people from the offices of Greece's former state broadcaster this morning , starting with journalist Nick Malkoutzis: Nick Malkoutzis (@NickMalkoutzis) 5 mths after flicking switch on public broadcaster ERT, gov't tries to settle issue by sending riot police to remove remaining staff #Greece November 7, 2013 Nick Malkoutzis (@NickMalkoutzis) While #ERT will be off air for good after police intervention, the stain of how its closure has been handled won't wash away easily #Greece November 7, 2013 Lady Mondegreen (@amaenad) Like a mean stupid dog appeasing a cruel master, the Greek government wants to lay ERT's limp body at the troika's feet.
(6) The government confirmed on Tuesday that the second year of the cull had begun, sparking outrage from animal rights activists, campaigners and opposition politicians who claim it is cruel and ineffective.
(7) Her friends have been arrested and subjected to what they describe as cruel and inhumane treatment .
(8) The jury decided unanimously Thursday that the Colorado attack was cruel enough to justify the death penalty .
(9) One of its board members is retired Major General Andrew James “Jim” Molan, co-architect of Tony Abbott’s “Operation Sovereign Borders,” the draconian program relying on the remote island detention centres condemned as cruel and inhumane by multiple respected human rights organisations.
(10) MOAB map “Isis were so cruel to us,” said Ahmad.
(11) Philip French championed Boyle's career from the outset, describing his debut feature film, Shallow Grave , as "a good piece of storytelling... Hitchcock would have admired its ruthlessness and cruel humour."
(12) S an Francisco is now a cruel place and a divided one.
(13) In a rather florid letter with classical, literary and historical references, he told her: "You, I already know from happy experience, will not be cruel to my tender flame … As I think of you I shall learn to love you more.
(14) Of course the timing was cruel, aimed at throwing the prime minister off balance just before what turned out to be a fairly successful Commons question time.
(15) He could be very charming, he could be very cruel, but he mattered and he put something together that was extraordinary."
(16) One of the first demands is that the bombardments by the regime and its [Russian] backers must end.” Merkel condemned the air raids on Syria’s second city as “inhumane and cruel”.
(17) While Liverpool seemed stretched by cruel successive away fixtures, Chelsea arguably mustered some of their finest attacking football of the campaign through that ferocious opening period.
(18) If you follow Twitter regularly, it's easy to believe that many of our fellow citizens are cruel, mean, misogynist and foul-mouthed.
(19) We perceive the circumstances of our youth as normal and unexceptional, however sparse or cruel they may be.
(20) "It's outrageous and cruel that people are taken off to detention and the families hear nothing until the body shows up with signs of abuse," said Joe Stork, deputy Middle East director at Human Rights Watch.