(n.) An ultimate particle of matter not necessarily indivisible; a molecule.
(n.) A constituent particle of matter, or a molecule supposed to be made up of subordinate particles.
(n.) The smallest particle of matter that can enter into combination; one of the elementary constituents of a molecule.
(n.) Anything extremely small; a particle; a whit.
(v. t.) To reduce to atoms.
Example Sentences:
(1) It has been conformed that catalase from bovine liver eliminates only the pro R hydrogen atom from ethanol.
(2) The results demonstrated that K2PtCl4 was bound to a greater degree than CDDP in this system with 3-5 and 1-2 platinum atoms respectively, bound per transferrin molecule.
(3) Richard Bull Woodbridge, Suffolk • Why does Britain need Chinese money to build a new atomic generator ( Letters , 20 October)?
(4) The bond distances of Cu to Cl(1), Cl(2), N(3) and N(3') atoms are 2.299 (1), 2.267 (1), 1.985 (4) and 1.996 (3) A, respectively.
(5) The common atoms of the [3Fe-4S] and [4Fe-4S] cores agree within 0.1 A; the three common cysteinyl S gamma ligand atoms agree within 0.25 A.
(6) This result was confirmed by atomic absorption spectroscopy, which indicated a stoicheiometry for copper and manganese of approx.
(7) The inter-molecular similarity measure used is the number of atoms in the 3-D common substructure (CS) between the two molecules which are being compared.
(8) The risks are determined, mainly by expert committees, from the steadily growing information on exposed human populations, especially the survivors of the atomic bombs dropped in Japan in 1945.
(9) All N and O atoms except N(3) and O(4') participate in a three-dimensional hydrogen-bonding system.
(10) This suggestion is supported by EPR studies, which show that the iron atoms in Fe(III)L-globin are in two low electronic states.
(11) The molar refractivity has been shown to be a superior parameter for the description of the activity of sulphonamides than the sum of electronegativities of atoms making up a heterocyclic substituent in the sulphonamide molecule and molecular weight of the substituent.
(12) Binding to HSA occurs primarily with the imidazolidine and thiazolidine groups of levamisole as it has been demonstrated by selective changes in the relaxation times and the chemical shifts of the protons attached to the carbon atoms.
(13) Each repeat unit contains thirty amino acids and is thought to bind a zinc atom using two cysteines and two histidines as ligands.
(14) NADP+ bound at the C8 atom in the adenine moiety proved to be the most efficient ligand whereas that bound at the C3 atom of the ribose moiety was relatively inefficient.
(15) This structure is further characterized by approaches of both the carbonyl and the furan O atoms to ring H atoms with separations which are slightly less than the sum of the relevant van der Waals radii.
(16) The magnitude of improvement achieved is dependent upon field size, SSD, the atomic number of the foil material, and foil thickness.
(17) For the liver enzyme, the logarithm of the inhibition constant was linearly related to the number of carbon atoms in the saturated fatty acids whereas the muscle enzyme, which was generally more strongly inhibited, showed a nonlinear dependence.
(18) Results obtained from a such study are here compared with levels obtained from a comparative determination of the metals in the mosses by three other techniques: Differential pulse anodic stripping voltammetry (DPASV), Direct current plasma (atomic emission) spectroscopy (DCPS) and X-ray fluorescence (XRF) spectroscopy.
(19) It was hypothesized that the observed activity variation of the paracetamol analogues was based on the relative abilities of these compounds to undergo H atom loss at the phenolic oxygen, and on the relative stabilities of the resulting free-radical species.
(20) The resulting family of structures has a mean backbone rmsd of 0.63 A (N, C alpha, C', O atoms), excluding the segments containing residues 45-59 and 84-88.
Disulphide
Definition:
(n.) A binary compound of sulphur containing two atoms of sulphur in each molecule; -- formerly called disulphuret. Cf. Bisulphide.
Example Sentences:
(1) Brief digestion at neutral pH without reduction produced a molecule in which the Fab and Fc fragments were still linked by a pair of labile disulphide bridges, and the Fc fragment released by cleaving these bonds, called 1Fc fragment, contained a portion of the ;hinge' region including an interchain disulphide bridge.
(2) The reactivity of the three disulphide bridges of insulin towards sodium sulphite was studied by amperometric titration of the liberated thiol groups.
(3) Limited trypsin digestion of purified platelet GPIIIa yielded a mixture of two-chain molecules comprised of an N-terminal fragment disulphide-bonded to one of four fragments, which began at residues 299, 303, 353 or 423.
(4) No disulphide bonds were observed in the subunit association.
(5) IPNS was rapidly inhibited by the thiol-blocking reagents N-ethylmaleimide and 2,2'- and 4,4'-dipyridyl disulphide, but not by 5,5'-dithiobis-(2-nitrobenzoic acid) in the same concentration.
(6) The symmetrical reagent 5,5'-dithiobis-(1-methyltetrazole) activates mitochondrial aldehyde dehydrogenase approximately 4-fold, whereas the smaller related compound methyl l-methyltetrazol-5-yl disulphide is a potent inactivator.
(7) Based on an understanding of the voltammetric behaviour of these biological molecules, which rely on the presence of the disulphide groups within their molecular structure for their electroactivity, it has been postulated that binding of cisplatin to these molecules occurs at the disulphide bond.
(8) Instead it suggests that carbon disulphide has some type of reversible, direct cardiotoxic or thrombotic effect.
(9) The hemolytic toxin (HT), isolated from the sea anemone Stoichactis helianthus, has been conjugated to a MAb directed against carcinoembryonic antigen (CEA), by means of an artificial disulphide bridge.
(10) This finding is supported by our having obtained similar results in PMN and whole blood with catalase (C), glutathione (GSH) and N-acetylcysteine (NAC) but not with penicillamine disulphide (PSSP) or superoxide dismutase.
(11) D-Penicillamine (D-pen), a thiol with antirheumatic activity, forms a mixed disulphide with albumin in vivo.
(12) The molecule, a homodimer formed by disulphide-linked chains of relative molecular mass (Mr) 140,000, is identified by a mouse monoclonal alloantibody called BP-1.
(13) One mole of oxygen is consumed for every 2 moles of dithiothreitol oxidized and the product is shown by spectral studies to be the intramolecular disulphide.
(14) The islet thiol:protein-disulphide oxidoreductase activity (EC 1.8.4.2) was apparently unchanged, whereas washing temperatures lower than 37 degrees C resulted in a diminished insulin content.
(15) In addition, there has been considerable concern over the lability of the disulphide bond between the toxophore and ligand components in vivo due to the action of disulphide reductases.
(16) The Cys 509-->Arg substitution eliminates an intramolecular disulphide bridge formed by Cys 509 and Cys 695 which is important to maintain the configuration of vWF functional domains that interact with platelet glycoprotein Ib-IX.
(17) This species appeared to consist of two disulphide-linked components each of Mr 50,000, with an additional 50,000-Mr chain attached non-covalently.
(18) Some regions of the delta subunit molecule, including the region containing the putative disulphide bridge and that encompassing the clustered putative transmembrane segments M1, M2 and M3, are relatively well conserved between calf and Torpedo.
(19) Whereas toxin CM-11 contains 65 amino acid residues and five intrachain disulphide bridges, toxin CM-2 and CM-12 comprise, respectively, 61 and 62 residues but both contain four disulphide bridges.
(20) In an attempt to define the 3D structure of this domain, the disulphide linkage pattern was determined and shown to be Cys 1-4, Cys 2-5 and Cys 3-6 in contradiction to an earlier report.