(n.) A poisonous, white, crystallizable alkaloid, extracted from the Atropa belladonna, or deadly nightshade, and the Datura Stramonium, or thorn apple. It is remarkable for its power in dilating the pupil of the eye. Called also daturine.
Example Sentences:
(1) Comparison if single injections of MSB and atropine in normal subjects also demonstrated a more reliable dose-response relationship with MSB.
(2) ), but it was potentiated by either atropine (5 mg kg-1 i.p.)
(3) Eight healthy, nonsmoking subjects received 1.7, 3.4, and 5.2 mg of atropine sulfate by inhalation and 1.67 mg of atropine free base (equivalent to 2 mg of atropine sulfate) by intramuscular (i.m.)
(4) Anti-histamine and anti-serotonin drugs, as well as substances capable of blocking synthesis of prostaglandins or activation of the kinin system, and also atropine, were ineffective in reducing the responses to TsTX or electrical stimuli.
(5) Neither atropine (1.4 X 10(-6) M) nor propranolol (3.4 X 10(-6) M) blocked the inhibitory action of neurotensin (10(-8) M) on the inhibitory potential.
(6) The effect was countered by prior administration of atropine into the site.
(7) The effects were atropine-resistant and qualitatively similar to those seen with cocaine.
(8) Atropine (1 microM) was used to block the muscarinic cholinoceptors.
(9) The vagally induced pyloric contraction was resistant to atropine but sensitive to SPA and hexamethonium, indicating involvement of SP in the activation of preganglionic neurons as well.
(10) Carbachol microinjected into the LRN also produced an antinociception which was attenuated significantly by atropine but not naloxone previously microinjected into the same site in the LRN.
(11) However, when parasympathetic activity was abolished by atropine and tracheal tone was restored with 5-hydroxytryptamine, benzodiazepines applied on the VMS had no effect on tracheal pressure.
(12) The inhibitory response was not decreased by treatment with atropine, hexamethonium, yohimbine or naloxone, suggesting that muscarinic, nicotinic, alpha 2 adrenergic or opiate receptors were not being stimulated.
(13) The inhibitory phase was blocked by atropine and the excitatory phase was eliminated by tubocurarine chloride, hexamethonium bromide or pindolol.
(14) Acetylcholine increases their turnover, Atropine reduces it, and the addition of atropine counteracts the effect of acetylcholine in all these phospholipids.
(15) Hypoxic exposure following atropine treatment resulted in progressive increases in PVA, Q and stroke volume; fH decreased during the recovery period.
(16) In LM strips, the contractile responses to tachykinins were unaffected by spantide and methysergide, but partly decreased by tetrodotoxin and atropine.
(17) Atropine significantly reduced rhinorrhea, the levels of histamine, and TAME-esterase activity as well as the osmolality of recovered lavage fluids, but had no effect on nasal congestion or albumin.
(18) Combined propranolol-atropine blockade increased heart rate at rest in the SAP state, and significantly attenuated the tachycardia accompanying treadmill exercise.
(19) Atropine inhibited insulin release induced by both acetylcholine and by 16.4 mM glucose.
(20) Atropine stimulated significantly the rat liver and esophagus carcinogenesis, whereas the alpha-adrenoblocking agent, a pyrrhoxane analogue, and, particularly, proserine inhibited these processes.
Hyoscyamine
Definition:
(n.) An alkaloid found in henbane (Hyoscyamus niger), and regarded as its active principle. It is also found with other alkaloids in the thorn apple and deadly nightshade. It is extracted as a white crystalline substance, with a sharp, offensive taste. Hyoscyamine is isomeric with atropine, is very poisonous, and is used as a medicine for neuralgia, like belladonna. Called also hyoscyamia, duboisine, etc.
Example Sentences:
(1) They received either glycopyrronium, or 1-hyoscyamine in a sustained-release form, or inert tablets for one year.
(2) The long-lasting decrease and increase in sinus rate were abolished by 1-hyoscyamine and propranolol respectively, and both were reduced by tetrodotoxin.
(3) Two colorimetric micromethods are described for the determination of atropine-hyoscyamine and hyoscine (scopolamine), using p-dimethylaminobenzaldehyde and citric acid-acetic anhydride as the color reagents.
(4) Its use in separating optical isomers of dl-scopolamine, dl-hyoscyamine, dl-homatropine, and dl-cocaine is discussed.
(5) Phenthonium (10-50 microM), a quaternary derivative of 1-hyoscyamine, increases the frequency of miniature end-plate potentials (2-5 fold) and blocks the nicotinic receptor-ionic channel in skeletal muscles.
(6) A new method for separation and determination of four important tropane alkaloids (hyoscyamine, scopolamine, anisodamine and anisodine) in crude drugs by micellar HPLC was developed.
(7) Columns (10 cm) filled with silical gel (particle size, 5 mum; pore size, 1000 A) show the best performance in the separation of hyoscyamine, scopolamine and ergotamine as picrate ion-pairs.
(8) Except for the more frequent reporting of dry mouth with L-hyoscyamine, side effects were not different among the groups.
(9) Diastereomeric urethane derivatives of atropine (d,l-hyoscyamine) and l-hyoscyamine were prepared by reacting the alkaloids with (-)-1-phenylethylisocyanate.
(10) In a randomized, double-blind, placebo controlled crossover study, the pharmacokinetics and some clinically important pharmacodynamic effects of intramuscular atropine (dl-hyoscyamine) were studied in 6 healthy male volunteers.
(11) This study compared the effects of glucagon (N = 48), L-hyoscyamine (N = 43), and placebo (N = 45) on gastric and duodenal distension, mucosal coating, and patient tolerance.
(12) L-Hyoscyamine provided gastric and duodenal images equal in quality to glucagon.
(13) The plasma concentrations of l-hyoscyamine were analyzed by radioreceptor assay (RRA) and the plasma concentrations of dl-hyoscyamine by radioimmunoassay (RIA).
(14) A simplified method for the quantitative analysis of hyoscyamine hydrobromide or atropine in Belladonna Tincture USP is described.
(15) This might at least partly explain the advantage of combining 1-hyoscyamine and an oxime with diazepam in intoxications with anticholinesterases.
(16) Tropine (tropan-3 alpha-ol) is an intermediate in the formation of hyoscyamine.
(17) The concentrations of d-hyoscyamine calculated from the dl- and l-hyoscyamine concentrations reached maximum between 1 and 2 h after drug injection.
(18) The renal excretion of l-hyoscyamine occurred mostly in 6 h (34% of the dose) and no conjugated drug forms were detected.
(19) By injecting the optical antipodes of atropine, D- and L-hyoscyamine separately in mice and following their kinetics in different parts of the brain it was possible to separate the specific receptor binding of the active antipode L-hyoscyamine from that of the inactive antipode D-hyoscyamine, representing unspecific binding.
(20) The assay is more selective for scopolamine (percent cross-reactions for hyoscyamine = 0.21%, 6-hydroxy-hyoscyamine = 0.17%) than previously reported immunoassays.