(n.) The beginner, former, or first mover of anything; hence, the efficient cause of a thing; a creator; an originator.
(n.) One who composes or writes a book; a composer, as distinguished from an editor, translator, or compiler.
(n.) The editor of a periodical.
(n.) An informant.
(v. t.) To occasion; to originate.
(v. t.) To tell; to say; to declare.
Example Sentences:
(1) He added: "There is a rigorous review process of applications submitted by the executive branch, spearheaded initially by five judicial branch lawyers who are national security experts and then by the judges, to ensure that the court's authorizations comport with what the applicable statutes authorize."
(2) Without medication atypical ventricular tachycardia develops, in the author's opinion, most probably when bradycardia has persisted for a prolonged period.
(3) The authors have presented in two previous articles the graphic solutions resembling Tscherning ellipses, for spherical as well as for aspherical ophthalmic lenses free of astigmatism or power error.
(4) The analysis is based on the personal experience of the authors with 117 cases and the review of 223 cases published in the literature.
(5) Handing Greater Manchester’s £6bn health and social care budget over to the city’s combined authority is the most exciting experiment in local government and the health service in decades – but the risks are huge.
(6) These authors, therefore, conclude that this modified surgical approach is a viable alternative to the previously described procedures for resistant metatarsus adductus.
(7) The authors empirically studied the self-medication hypothesis of drug abuse by examining drug effects and motivation for drug use in 494 hospitalized drug abusers.
(8) At the heart of the payday loan profit bonanza is the "continuous payment authority" (CPA) agreement, which allows lenders to access customer bank accounts to retrieve funds.
(9) The authors report 4 new cases of heterotopic pancreas in children with prepyloric, jejunal, Meckel's diverticulum and mesenteric localization.
(10) A tiny studio flat that has become a symbol of London's soaring property prices is to be investigated by planning, environmental health and fire safety authorities after the Guardian revealed details of its shoebox-like proportions.
(11) For his lone, perilous journey that defied the US occupation authorities, Burchett was pilloried, not least by his embedded colleagues.
(12) The playing fields on which all those players began their journeys have been underfunded for years and are now facing a renewed crisis because of cuts to local authority budgets.
(13) Different therapeutic success rates have been reported by various authors who used the same combination of therapy.
(14) No report can be taken seriously if its authors weren’t even in Yemen to conduct investigations.” The UN team was not given permission to enter the country.
(15) Migrant voters are almost as numerous as current Ukip supporters but they are widely overlooked and risk being increasingly disaffected by mainstream politics and the fierce rhetoric around immigration caused partly by the rise of Ukip,” said Robert Ford from Manchester University, the report’s co-author.
(16) The dangers caused by PM10s was highlighted in the Rogers review of local authority regulatory services, published in 2007, which said poor air quality contributed to between 12,000 and 24,000 premature deaths each year.
(17) The authors conclude that H. pylori alone causes little or no effect on an intact gastric mucosa in the rat, that either intact organisms or bacteria-free filtrates cause similar prolongation and delayed healing of pre-existing ulcers with active chronic inflammation, and that the presence of predisposing factors leading to disruption of gastric mucosal integrity may be required for the H. pylori enhancement of inflammation and tissue damage in the stomach.
(18) The authors report an ocular luxation of a four-year-old girl after a bicycle accident.
(19) For the case described by the author primary tearing of the chiasma due to sudden applanation of the skull in the frontal region with burstfractures in the anterior cranial fossa is assumed.
(20) Midtrimester abortion by the dilatation and evacuation (D&E) method has generated controversy among health care providers; many authorities insist that this procedure should be performed only by a small group of experts.
Cascade
Definition:
(n.) A fall of water over a precipice, as in a river or brook; a waterfall less than a cataract.
(v. i.) To fall in a cascade.
(v. i.) To vomit.
Example Sentences:
(1) With fields and fells already saturated after more than four times the average monthly rainfall falling within the first three weeks of December, there was nowhere left to absorb the rainfall which has cascaded from fields into streams and rivers.
(2) The following model is suggested: exogenous ATP interacts with a membrane receptor in the presence of Ca2+, a cascade of events occurs which mobilizes intracellular calcium, thereby increasing the cytosolic free Ca2+ concentration which consequently opens the calcium-activated K+ channels, which then leads to a change in membrane potential.
(3) Each point of the interleukin cascade reaction was examined.
(4) All cellular signals characterized so far are reverted during retrodifferentiation: Redistribution of PKC and down-regulation of c-fos and c-jun contribute to an interruption of the differentiation-associated transsignaling cascade.
(5) Present antihypertensive therapy is directed largely at secondary factors dependent upon or influencing the primary phospholipase C cascade.
(6) Since testosterone influenced both tissue stores and PDBu-stimulated secretion of LHRH and GAP, this steroid may selectively regulate biosynthesis and secretion of pro-LHRH-derived peptides through activation of the metabolic cascade involving the PKC system.
(7) Extracellular signals that promote cell growth activate cascades of protein kinases.
(8) Using serine proteinase inhibitors and antibodies to plasminogen activators as well as a newly described collagenase inhibitor we demonstrate that a protease cascade leads to the activation of an enzyme(s) that cleaves collagen IV.
(9) Low-density lipoprotein (LDL) has a similar hormone-like action and activates the signal transfer cascade that eventually leads to platelet aggregation as well as vascular smooth muscle cell proliferation.
(10) However, the role of calcium homeostasis in regulating several biochemical pathways implicated in other steps of the metastatic cascade suggests that calcium channel antagonists could also inhibit metastasis by other mechanisms.
(11) Since ADH exerts its effects by activation of adenylyl cyclase (AC), further experiments were performed to identify the site at which CP inhibits this cascade.
(12) Autoantibodies which interfere with the function of enzyme cascade systems have also been described in diseases such as acquired haemophilia (anti-factor VIII antibodies) and glomerulonephritis (C3 nephritic factor).
(13) The cyclic adenosine nucleotide pathway is turned off by kinase A activity, whereas the inositol trisphosphate cascade is terminated by kinase C. The data support the concept that desensitization of odorant responses involves phosphorylation of key elements in the transduction cascade.
(14) These hormonal responses trigger a cascade of metabolic adjustments leading to catabolism and substrate mobilization in the postoperative period.
(15) The series filter model is compatible with a simply physical model consisting of cascaded chemical reactions whose forward rate constants are reciprocals of the filter time constants, whose reverse rate constants are negligible, and in which the concentration of an intermediate product controls membrane current.
(16) E capture IC via complement receptors, type 1 (CR1) which can bind to C3b and C4b ligand sites generated on IC during activation of the complement cascade.
(17) The EU was not properly promoting cascade use either he said.
(18) Speculatively, the blockage by dbcAMP of the morphogenetic cascade in the co-cultured system may be related to the inhibition by dbcAMP of testis cord formation in organ cultures of fetal gonads reported by others.
(19) Component of the cascade model represented adventitia and media layers of the wall.
(20) These data suggest that sCR1 inhibits the Arthus reaction by interrupting the activation of the C cascade, hence limiting the detrimental immune complex-induced tissue damage in vivo.