(a.) Destitute of any vestige of organic life, or at least of animal life; anterior to the existence of animal life; formed when there was no animal life on the globe; as, the azoic. rocks.
Example Sentences:
(1) The others are used orally by preserving the Salazopyrin structure and its azoic link, like di-ASA (Dipentum) or by coating 5 ASA to allow its release in the distal bowel (Asacol, Claversal, Salofalk, Pentasa).
(2) The frequencies of SCEs were recorded in a group of workers exposed to azoic dyes and in a control group.
(3) A new complex of tetrachloroplatinum(II) and the azoic diazo dye, Fast Black K, Pt(Fast Black)2, was made in an attempt to produce an uncharged molecule which could readily gain access into cells and could bring a high concentration of tetrachloroplatinum into the vicinity of the DNA.
Azonic
Definition:
(a.) Confined to no zone or region; not local.
Example Sentences:
(1) A marked analgesic effect was found after application of morphine hydrochloride patch containing Azone and N-methyl-2-pyrrolidone.
(2) During the early part of the experiments, when the sink condition was maintained, FAH was the most effective for hairless mouse skin, whereas Azone showed the highest effect in the rat skin.
(3) Azone doubled the amount of PFA in the skin, more than tripled the amount permeated across the skin, and increased the flux fourfold.
(4) The addition of Azone (3%) or lauric acid (BH: lauric acid molar ratio, 1:1) considerably increased BH penetration to a relatively large penetration rate.
(5) In order to develop the transdermal formulations of morphine hydrochloride with high skin permeation rate and prolonged action, several gels and patches containing potent penetration enhancer, laurocapram (Azone), were prepared.
(6) The results indicate that Azone may be capable of forming ion pairs with anionic drugs.
(7) The efficacy of 5 and 10% Azone applied topically was evaluated during the treatment of HSV-1 cutaneous infections in guinea pigs.
(8) The performance of Tween 80, Tween 60, oleic acid, oleyl alcohol and Azone as enhancers of clonazepam permeation from a Carbopol hydrogel through a cellulose nitrate membrane was investigated.
(9) At the same time, plasma concentrations were maintained at a high level for more than 7 h. The increase in bioavailability is presumed to be caused by an enhancement in absorption and prolongation of the time DA is retained in the nasal cavity due to Azone and HPC, respectively.
(10) Azone and NMP showed maximum efficacy at 0.1% and 12.0% concentration, respectively.
(11) 0.5 ml solutions of different pH (3, 4, 5, 6, 7.5) or of pH 7.5 in combination with sorption promoters (sodium taurocholate, dextran sulfate, linoleic acid, TranscutolR, LabrafilR M 1944 CS, urea and AzoneR) were administered for 0.5 h to anesthetized dogs.
(12) The tests were conducted with 2',3'-di-O-acetyl-ara-A (4) and 5'-O-valeryl-ara-A (3) topically applied with and without 15% 1-dodecylazacycloheptan-2-one (2) (Azone), a percutaneous penetration enhancer.
(13) From these results, it was predicted that the topical formulations of morphine hydrochloride containing Azone and N-methyl-2-pyrrolidone might be useful for the relief of severe chronic pain in patients.
(14) First, the effect of Azone on the skin components was compared with that of other penetration enhancers.
(15) Two cleavage stage embryos, two blastocyts surrounded by zona pellucida, and two azonal ('hatched') blastocysts were recovered from uteri of rhesus monkeys and examined with the electron microscope.
(16) Both the in vitro permeation and the in vivo absorption of propranolol across the cheek pouch were enhanced by the incorporation of Azone to the film-dosage form.
(17) In addition, ethanol increased the amount of free sulfhydryl (SH) group of keratin in the stratum corneum, whereas Azone did not directly affect the stratum corneum protein.
(18) Azone increased percutaneous penetration of HpD in human skin in vitro.
(19) In order to clarify the mechanism of action of laurocapram (Azone) on the skin permeation of drugs, the following experiments were done.
(20) In contrast, the enhancing effect of Azone on the pretreated skin was similar to that of Azone on the in vitro non-treated skin.