(1) A marked analgesic effect was found after application of morphine hydrochloride patch containing Azone and N-methyl-2-pyrrolidone.
(2) During the early part of the experiments, when the sink condition was maintained, FAH was the most effective for hairless mouse skin, whereas Azone showed the highest effect in the rat skin.
(3) Azone doubled the amount of PFA in the skin, more than tripled the amount permeated across the skin, and increased the flux fourfold.
(4) The addition of Azone (3%) or lauric acid (BH: lauric acid molar ratio, 1:1) considerably increased BH penetration to a relatively large penetration rate.
(5) In order to develop the transdermal formulations of morphine hydrochloride with high skin permeation rate and prolonged action, several gels and patches containing potent penetration enhancer, laurocapram (Azone), were prepared.
(6) The results indicate that Azone may be capable of forming ion pairs with anionic drugs.
(7) The efficacy of 5 and 10% Azone applied topically was evaluated during the treatment of HSV-1 cutaneous infections in guinea pigs.
(8) The performance of Tween 80, Tween 60, oleic acid, oleyl alcohol and Azone as enhancers of clonazepam permeation from a Carbopol hydrogel through a cellulose nitrate membrane was investigated.
(9) At the same time, plasma concentrations were maintained at a high level for more than 7 h. The increase in bioavailability is presumed to be caused by an enhancement in absorption and prolongation of the time DA is retained in the nasal cavity due to Azone and HPC, respectively.
(10) Azone and NMP showed maximum efficacy at 0.1% and 12.0% concentration, respectively.
(11) 0.5 ml solutions of different pH (3, 4, 5, 6, 7.5) or of pH 7.5 in combination with sorption promoters (sodium taurocholate, dextran sulfate, linoleic acid, TranscutolR, LabrafilR M 1944 CS, urea and AzoneR) were administered for 0.5 h to anesthetized dogs.
(12) The tests were conducted with 2',3'-di-O-acetyl-ara-A (4) and 5'-O-valeryl-ara-A (3) topically applied with and without 15% 1-dodecylazacycloheptan-2-one (2) (Azone), a percutaneous penetration enhancer.
(13) From these results, it was predicted that the topical formulations of morphine hydrochloride containing Azone and N-methyl-2-pyrrolidone might be useful for the relief of severe chronic pain in patients.
(14) First, the effect of Azone on the skin components was compared with that of other penetration enhancers.
(15) Two cleavage stage embryos, two blastocyts surrounded by zona pellucida, and two azonal ('hatched') blastocysts were recovered from uteri of rhesus monkeys and examined with the electron microscope.
(16) Both the in vitro permeation and the in vivo absorption of propranolol across the cheek pouch were enhanced by the incorporation of Azone to the film-dosage form.
(17) In addition, ethanol increased the amount of free sulfhydryl (SH) group of keratin in the stratum corneum, whereas Azone did not directly affect the stratum corneum protein.
(18) Azone increased percutaneous penetration of HpD in human skin in vitro.
(19) In order to clarify the mechanism of action of laurocapram (Azone) on the skin permeation of drugs, the following experiments were done.
(20) In contrast, the enhancing effect of Azone on the pretreated skin was similar to that of Azone on the in vitro non-treated skin.
Local
Definition:
(a.) Of or pertaining to a particular place, or to a definite region or portion of space; restricted to one place or region; as, a local custom.
(n.) A train which receives and deposits passengers or freight along the line of the road; a train for the accommodation of a certain district.
(n.) On newspaper cant, an item of news relating to the place where the paper is published.
Example Sentences:
(1) The patterns observed were: clusters of granules related to the cell membrane; positive staining localized to portions of the cell membrane, and, less commonly, the whole cell circumference.
(2) A series of human cDNA clones of various sizes and relative localizations to the mRNA molecule were isolated by using the human p53-H14 (2.35-kilobase) cDNA probe which we previously cloned.
(3) The predicted non-Lorentzian line shapes and widths were found to be in good agreement with experimental results, indicating that the local orientational order (called "packing" by many workers) in the bilayers of small vesicles and in multilamellar membranes is substantially the same.
(4) Villagers, including one man who has been left disabled and the relatives of six men who were killed, are suing ABG in the UK high court, represented by British law firm Leigh Day, alleging that Tanzanian police officers shot unarmed locals.
(5) It would be fascinating to see if greater local government involvement in running the NHS in places such as Manchester leads over the longer term to a noticeable difference in the financial outlook.
(6) This scintigraphic localization of osteomyelitis seldom has been reported.
(7) Local embolism, vertebral distal-stump embolism, the dynamics of hemorrhagic infarction and embolus-in-transit are briefly described.
(8) This computer is connected to a fileserver via a local area network and is used exclusively for data acquisition.
(9) In addition autoradiography was performed to localize labelled cells in the inner ear.
(10) Handing Greater Manchester’s £6bn health and social care budget over to the city’s combined authority is the most exciting experiment in local government and the health service in decades – but the risks are huge.
(11) Community owned and run local businesses are becoming increasingly common.
(12) This effect was more marked in breast cancer patients which may explain our earlier finding that women with upper body fat localization are at increased risk for developing breast cancer.
(13) This study was designed to investigate the localization and cyclic regulation of the mRNA for these two IGFBPs in the porcine ovary, RNA was extracted from whole ovaries morphologically classified as immature, preovulatory, and luteal.
(14) These findings suggest that clonidine transdermal disks lower blood pressure in hypertensive patients, but produce local skin lesions and general side effects.
(15) Angiopathic and traumatic influences conditioned by metabolism, apart from local peculiarities are taken into consideration.
(16) Immunofluorescence analysis of Pr-28 antigen showed that the antigen was localized mainly in perinuclear cytoplasm.
(17) The authors report 4 new cases of heterotopic pancreas in children with prepyloric, jejunal, Meckel's diverticulum and mesenteric localization.
(18) The Nazi extermination of Jews in Lithuania (aided enthusiastically by local Lithuanians) was virtually total.
(19) Results in May 89 emphasizes: the relevance and urgency of the prevention of AIDS in secondary schools; the importance of the institutional aspect for the continuity of the project; the involvement of the pupils and the trainers for the processus; the feasibility of an intervention using only local resources.
(20) The amino-terminal region of a 70 kDa mitochondrial outer membrane protein of yeast and the presequence of cytochrome c1, an inner membrane protein exposed to the intermembrane space, are thought to be responsible for localizing the proteins in their final destinations after synthesis in the cytosol.