(1) A marked analgesic effect was found after application of morphine hydrochloride patch containing Azone and N-methyl-2-pyrrolidone.
(2) During the early part of the experiments, when the sink condition was maintained, FAH was the most effective for hairless mouse skin, whereas Azone showed the highest effect in the rat skin.
(3) Azone doubled the amount of PFA in the skin, more than tripled the amount permeated across the skin, and increased the flux fourfold.
(4) The addition of Azone (3%) or lauric acid (BH: lauric acid molar ratio, 1:1) considerably increased BH penetration to a relatively large penetration rate.
(5) In order to develop the transdermal formulations of morphine hydrochloride with high skin permeation rate and prolonged action, several gels and patches containing potent penetration enhancer, laurocapram (Azone), were prepared.
(6) The results indicate that Azone may be capable of forming ion pairs with anionic drugs.
(7) The efficacy of 5 and 10% Azone applied topically was evaluated during the treatment of HSV-1 cutaneous infections in guinea pigs.
(8) The performance of Tween 80, Tween 60, oleic acid, oleyl alcohol and Azone as enhancers of clonazepam permeation from a Carbopol hydrogel through a cellulose nitrate membrane was investigated.
(9) At the same time, plasma concentrations were maintained at a high level for more than 7 h. The increase in bioavailability is presumed to be caused by an enhancement in absorption and prolongation of the time DA is retained in the nasal cavity due to Azone and HPC, respectively.
(10) Azone and NMP showed maximum efficacy at 0.1% and 12.0% concentration, respectively.
(11) 0.5 ml solutions of different pH (3, 4, 5, 6, 7.5) or of pH 7.5 in combination with sorption promoters (sodium taurocholate, dextran sulfate, linoleic acid, TranscutolR, LabrafilR M 1944 CS, urea and AzoneR) were administered for 0.5 h to anesthetized dogs.
(12) The tests were conducted with 2',3'-di-O-acetyl-ara-A (4) and 5'-O-valeryl-ara-A (3) topically applied with and without 15% 1-dodecylazacycloheptan-2-one (2) (Azone), a percutaneous penetration enhancer.
(13) From these results, it was predicted that the topical formulations of morphine hydrochloride containing Azone and N-methyl-2-pyrrolidone might be useful for the relief of severe chronic pain in patients.
(14) First, the effect of Azone on the skin components was compared with that of other penetration enhancers.
(15) Two cleavage stage embryos, two blastocyts surrounded by zona pellucida, and two azonal ('hatched') blastocysts were recovered from uteri of rhesus monkeys and examined with the electron microscope.
(16) Both the in vitro permeation and the in vivo absorption of propranolol across the cheek pouch were enhanced by the incorporation of Azone to the film-dosage form.
(17) In addition, ethanol increased the amount of free sulfhydryl (SH) group of keratin in the stratum corneum, whereas Azone did not directly affect the stratum corneum protein.
(18) Azone increased percutaneous penetration of HpD in human skin in vitro.
(19) In order to clarify the mechanism of action of laurocapram (Azone) on the skin permeation of drugs, the following experiments were done.
(20) In contrast, the enhancing effect of Azone on the pretreated skin was similar to that of Azone on the in vitro non-treated skin.
Zone
Definition:
(n.) A girdle; a cincture.
(n.) One of the five great divisions of the earth, with respect to latitude and temperature.
(n.) The portion of the surface of a sphere included between two parallel planes; the portion of a surface of revolution included between two planes perpendicular to the axis.
(n.) A band or stripe extending around a body.
(n.) A band or area of growth encircling anything; as, a zone of evergreens on a mountain; the zone of animal or vegetable life in the ocean around an island or a continent; the Alpine zone, that part of mountains which is above the limit of tree growth.
(n.) A series of planes having mutually parallel intersections.
(n.) Circuit; circumference.
(v. t.) To girdle; to encircle.
Example Sentences:
(1) The most actively proliferating region of the excurrent duct system is zone 3 of the epididymis, whereas the least active region is the ductuli efferentes.
(2) There was a linear increase in the dimensions of these zones after the chewing.
(3) In hypophysectomized rats the activity of alanine aminotransferase was increased, but its normal zonation (predominance in the periportal zone) was preserved.
(4) The lesion (10.6 X 9.8 mm) was a well-defined ellipsoid granuloma due to a foreign body with a central zone of necrosis surrounded entirely by a fibrous wall.
(5) Anterior borderzone brachial paralysis (ABBP) is a hemodynamic ischemic syndrome of the watershed zone between the anterior and middle cerebral arteries.
(6) Employed method of observation gave quantitative information about the influence of odours on ratios of basic predeterminate activities, insect distribution pattern and their tendency to choose zones with an odour.
(7) In case of isolated damage of deep flexor tendon of the II-V fingers at the level of the I zone there were made palliative operations of 12 fingers: tenodesis and arthrodesis of distal interphalangeal articulation in functionally advantageous position.
(8) Good follow-up results in the zone 2, 3, 4 and 6 of VERDAN are observed only 6 to 17 percent (fig.
(9) The changes were apparent as hypofluorescent zones in the angiogram.
(10) The use of functional test with the ACTH administration demonstrated organic affection of the CNS to sharply aggravate the weakening and even the exhaustion of the functional reserves of the glomerular and the reticular zones of the adrenal cortex developing during thyrotoxicosis, and also the reserve possibilities of the sympathico-adrenal system.
(11) In the dark cortical zone of the nodes (III group) there occur tissue basophils (mast cells), that, together with increasing number of acidophilic granulocytes and appearance of neutrophilic cells, demonstrates that there is an inflammatory reaction in the organ studied as a response to the lymphocytic suspension injected.
(12) Results of detailed studies on tissue reactions to Cysticercus bovis in the heart of cattle, together with a comparison of findings in animals with spontaneous and experimental infection, and an evaluation of tissue reactions in relation to the location, morphology and morphogenesis of C. bovis provided evidence for the fact that in general, the response of the heart to the presence of C. bovis was an inflammatory reaction characterized by the origin of a pseudoepithelial border and a zone of granulation tissue.
(13) However, in the normal and border zones of the verapamil group the mitochondria are smaller when compared with the respective zones in the two other groups, but increases relatively more in size in the border and ischaemic zones.
(14) Refolding was observed by injection of denatured protein into columns having isocratic concentrations in the transition and native base-line zones.
(15) The distribution of cells at the stage of DNA synthesis and mitosis in all the parietal peritoneum speaks of the absence of special proliferation zones.
(16) Subcortical leukomalacia occurs in this triangle as well as in border zones between the major cerebral arteries.
(17) This contrasts sharply with the reduction in both the frequency and surface area of sensory neuron active zones that accompanies long-term habituation, and suggests that modulation of active zone number and size may be an anatomical correlate that lies in the long-term domain.
(18) Thus, multiparae had very thick border zones composed predominantly of large nodules and, additionally, of vacuolated cells and fibrous tissue.
(19) Acute transmural myocardial infarction has been reported to functionally denervate the normal myocardium distal to the infarcted zone by interrupting neurotransmission in axons coursing in the subepicardial region of the myocardial necrosis.
(20) In the modified test, shake cultures in Brewer's fluid thioglycolate medium with 0.3% agar added are observed for growth in the anaerobic zone of the tubes.