(1) Responses of bovine adrenal capillary endothelial cells (BACE) on treatment with transforming growth factor beta 1 (TGF-beta 1) have been characterized and tested for sensitivity to inactivation of pertussis toxin-sensitive G-proteins.
(2) Analysis of p34cdc2 activity in BACE cells revealed potent inhibition of p34cdc2 histone H1 kinase activity by TGF-beta 1.
(3) Angiogenin modulates mitogenic stimuli in bovine adrenal capillary endothelial (BACE), rat aortic smooth muscle (RASM), and fibroblast (3T3) cells.
(4) Further investigation revealed that pertussis toxin treatment of BACE cells had no effect on TGF-beta 1-stimulated elevation of steady state mRNA levels for collagen type 1 (alpha 1(1) or alpha 2(1)) or for TGF-beta 1.
(5) The addition of SP to serum-free cultured endothelial cells, isolated from bovine adrenals (BACE) and from human umbilical cord veins (HUVE), increased proliferation of both cell lines in a concentration-dependent manner with maximal activity at 10(-8) M (BACE) and 10(-10) M (HUVE).
(6) Pertussis toxin treatment enhanced both inhibition of BACE cell [3H]methylthymidine uptake and remodeling of BACE monolayers by TGF-beta 1.
(7) TGF-beta 1 elicited growth inhibition, monolayer remodeling, elevation of steady state mRNA levels for collagen type 1 (alpha 1(1) and alpha 2(1)) and TGF-beta 1, and inhibition of p34cdc2 histone H1 kinase activity in BACE cells.
(8) Consistent with suppression of p34cdc2 activation, pertussis toxin also caused substantial inhibition of mitogen-stimulated BACE cell [3H]methylthymidine uptake.
(9) Thus, it enhances the mitogenic effect of certain conditioned media on RASM and 3T3 cells, but it inhibits the mitogenic effect on BACE cells.
Drubbing
Definition:
(p. pr. & vb. n.) of Drub
Example Sentences:
(1) This drubbing exposed not only the team's inadequacy on the day in the face of a rampant United side who sensed miserable resistance almost from the kick-off, but also Arsène Wenger's tepid commitment to the FA Cup, whatever his ready-made complaints of depleted resources before and after.
(2) Brown spoke out after seven cabinet attendees quit government and Labour suffered a drubbing in the local elections.
(3) It's the drubbing he's received from sections of the British press for The Wind That Shakes the Barley, his Palme d'Or-winning film about the Irish war of independence, starring Cillian Murphy.
(4) The British men have been through an "I get knocked down but I get up again" tournament, coming back miraculously on a couple of occasions – including in an earlier match against the Aussies – to make it out of the group before suffering a proper drubbing in the semi-final, 9-2 against the brilliant orange Dutch.
(5) However, a 4-0 drubbing at home to Bournemouth on the opening day of the campaign led to the manager and his players being jeered by fans.
(6) Despite England's Ashes drubbing by the Australians, Test Match Special, which airs on Radio 4 long wave and the digital station 5 Live Sports Extra, accounted for 19 of the top 20 requested radio shows.
(7) Philippe Coutinho’s brilliantly taken winner, struck from fully 30 yards, will not expel the memories of that 6-1 drubbing when Steven Gerrard’s final match for the club turned into the kind of harrowing ordeal a man with his history could scarcely have thought plausible.
(8) What's certain, though, is that nothing could have been worse than keeping the spineless Ayrault at his side after last weekend's drubbing at the local elections and the loss of 175 municipalities.
(9) A bath” – for the uninitiated – is a Spanish way of saying a drubbing, or a whitewash; a real beating.
(10) Wenger lamented again how the campaign had been scarred by the high-profile away-day drubbings, most gruesomely the 6-0 at Stamford Bridge, which reignited all of those questions about Arsenal's knowhow.
(11) The turnaround was even more amazing given that Scotland had won the previous year's match 7-2, a score that remained England's worst drubbing until they popped over to Budapest in 1954 for their 7-1 humiliation at the hands of the Hungarians.
(12) A training ground set-to following September’s drubbing by Celtic led to a classic Barton apology, laced with the qualifier: “I cannot apologise for caring deeply about winning.” His suspension, then his departure, followed swiftly.
(13) Look at the history of byelections throughout the ages - midterm governments tend to get a drubbing".
(14) They also show that entrapment in liposomes can reduce metabolic degradation of a drub, maintain high plasma levels and reduce its renal excretion.
(15) There are three separate satirical programmes on Geo, the country’s biggest and most watched independent television channel, where politicians come in for a regular drubbing.
(16) However, the serotonin depleting drub para-chlorophenylalanine produced a marked increase in decremental bar pressing compared to saline-injected controls.
(17) I'm tempted as I think Liverpool might bottle it against Newcastle, Chelsea should see off an awful Cardiff team and even though plucky little City will probably get a drubbing against Big Sam's claret and blue army they'll still finish first.
(18) Walker’s last appearance at Stamford Bridge was the 4-0 drubbing in March 2014 , after which the Spurs manager at the time, Tim Sherwood, questioned the character of his players .
(19) They had fluffed their lines in the 4-0 Boxing Day drubbing at Southampton but there was reassurance here against a Bournemouth team that looked tidy enough but lacked ruthlessness at both ends.
(20) For Cook, considering another drubbing by the analysts, that might have to do.