(n.) The column of bones in the back which sustains and gives firmness to the frame; the spine; the vertebral or spinal column.
(n.) Anything like , or serving the purpose of, a backbone.
(n.) Firmness; moral principle; steadfastness.
Example Sentences:
(1) A method for the introduction of side chains containing isonitrile (isocyanide, functional group) on the backbone of polysaccharides and other hydroxylic polymers was developed.
(2) The chromophore of octopus rhodopsin is 11-cis retinal, linked via a protonated Schiff base to the protein backbone.
(3) An unprincipled coward with the backbone of an amoeba."
(4) The Pr(III)-induced shifts for several resolved nonexchangeable backbone proton resonances were compared with calculated shifts using the known x-ray structure.
(5) Here we present images of polydeoxyadenylate molecules aligned in parallel, with their bases lying flat on a surface of highly oriented pyrolytic graphite and with their charged phosphodiester backbones protruding upwards.
(6) These data suggest that the somnogenic actions of these lipid A analogs depend on the acylation or phosphorylation pattern and backbone structures of the molecules.
(7) The resulting family of structures has a mean backbone rmsd of 0.63 A (N, C alpha, C', O atoms), excluding the segments containing residues 45-59 and 84-88.
(8) wt polypeptide backbone, modified by an endoglycosidase F-sensitive carbohydrate moiety.
(9) The backbone dynamics of Ca(2+)-saturated recombinant Drosophila calmodulin has been studied by 15N longitudinal and transverse relaxation experiments, combined with 15N(1H) NOE measurements.
(10) A central eight-stranded beta-pleated sheet is the main feature of the polypeptide backbone folding in dihydrofolate reductase.
(11) To investigate the topochemical preference of backbone and side chains, unusual amino acids, including beta-methylphenylalanine7 or 11, beta-methyltryptophan8, as well as backbone modifications such as retro-inverso structures have been incorporated.
(12) The angle obtained for the C alpha-D resonance was consistent with a single-stranded beta 6.3-helical model for the backbone but not with double-helical models.
(13) In the holopeptide corticotropin, the side chain-side chain effects, as reflected by the titration curves obtained from variations in the aromatic region, support the idea of an helical organization of part of the backbone even in aqueous solution.
(14) The local secondary structure was calculated from sequential and medium-range backbone NOEs with the double-iterated Kalman filter method [Altman, R. B., & Jardetzky, O.
(15) Although the (n-h) plots predict the stereochemical possibility of both right-handed and left-handed helices, nucleic acids apparently prefer right-handed conformation because of the energetics associated with the sugar-phosphate backbone and the base.
(16) And 96% of our grants go to African organisations, universities, scientists and small businesses to achieve a single goal: reduce hunger and poverty on our continent by unleashing the potential of the millions of small, family farmers who are the backbone of African agriculture and African economies.
(17) In addition the bare central backbone showed transverse striations.
(18) Misfolded models were constructed by introducing incorrect side chains onto polypeptide backbones: side chains of the alpha-helical hemerythrin were modeled on the beta-sheeted backbone of immunoglobulin VL domain, whereas those of the VL domain were similarly modeled on the hemerythrin backbone.
(19) Complete assignments were obtained for the backbone 1H, 15N and 13C resonances, using three-dimensional heteronuclear 1H NOE 1H-15N multiple-quantum coherence spectroscopy (3D-NOESY-HMQC) and three-dimensional heteronuclear total correlation 1H-15N multiple-quantum coherence spectroscopy (3D-TOCSY-HMQC) experiments on 15N-enriched HPr and an additional three-dimensional triple-resonance 1HN-15N-13C alpha correlation spectroscopy (HNCA) experiment on 13C, 15N-enriched HPr.
(20) Teh presence of the polyglycerol phosphate backbone and fatty acid was required for maximum immunosuppression of the primary immunoglobulin M response to sheep cells.
Courage
Definition:
(n.) The heart; spirit; temper; disposition.
(n.) Heart; inclination; desire; will.
(n.) That quality of mind which enables one to encounter danger and difficulties with firmness, or without fear, or fainting of heart; valor; boldness; resolution.
Example Sentences:
(1) I know I have the courage to deal with all the sniping but you worry about the effects on your family."
(2) It also devalues the courage of real whistleblowers who have used proper channels to hold our government accountable.” McCain added: “It is a sad, yet perhaps fitting commentary on President Obama’s failed national security policies that he would commute the sentence of an individual that endangered the lives of American troops, diplomats, and intelligence sources by leaking hundreds of thousands of sensitive government documents to WikiLeaks, a virulently anti-American organisation that was a tool of Russia’s recent interference in our elections.” WikiLeaks last year published emails hacked from the accounts of the Democratic National Committee and John Podesta, chairman of Hillary Clinton’s election campaign.
(3) He made me laugh and cry, and his courage in writing about what he was going through was sometimes quite overwhelming.
(4) Gin was popularised in the UK via British troops who were given the spirit as “Dutch courage” during the 30 years’ war.
(5) This was a courageous move in a society where women were confined to purdah.
(6) The woman said it took her until the mid-1990s to pluck up the courage to report the abuse to Jersey's children's services department – and that her allegations were not taken seriously enough.
(7) My hope is that those who are at the Games take these words and let them echo, with grace, courage and dignity, in whatever way they choose to, because it will make a difference to those participating, and to those watching.
(8) After Japanese troops invaded the Chinese city of Nanking (now Nanjing) in 1937, slaughtering tens of thousands of civilians, Hirohito said he was "deeply satisfied" by the troops' courage in quickly seizing the city.
(9) And with that courage, we can stand together for good jobs and just wages.
(10) Honest journalism and the courageous whistleblowers who denounce human rights violations or attempts against state sovereignty deserve to be protected.
(11) These inspiring and courageous women are up against a highly resourced state that looks after its own.
(12) Congratulating Mr Rabin and Mr Arafat on having the courage to change, a Clintonite speciality, he went on: 'Above all, let us dedicate ourselves to your region's next generation.
(13) Alicia deserves praise for courageously standing up to Trump’s attacks.
(14) In the Russian gallery, for example, the courageous Vadim Zakharov presents a pointed version of the Danaë myth in which an insouciant dictator (of whom it is hard not to think: Putin) sits on a high beam on a saddle, shelling nuts all day while gold coins rain down from a vast shower-head only to be hoisted in buckets by faceless thuggish men in suits.
(15) They’re losing fear and they’re gaining courage, especially from the military positions he’s taken.
(16) They had announced Thursday that "as a result of our public appeal for help, a courageous and compassionate individual came forward to provide the assistance needed to properly bury the deceased."
(17) Essential traits of this personality are an independent mind capable of liberating itself from dogmatic tenets universally accepted by the scientific community; the capacity and courage to look at things from a new angle; powers of combination, intuition and imagination; feu sacré and perseverance--in short, intellectual as well as moral qualities.
(18) Cubism as practised by Picasso and Braque they thought courageous, up to a point, but misguided.
(19) The doubts over what some see as Miliband's lack of presentational skills and "wonkiness" have, in part, been stilled by his flashes of courage and intuitive accord with the public mood – on Libor, on predatory capitalism, on Murdoch.
(20) It cannot be right that anyone who has found the courage to escape their abusive or violent partner should be subjected to the stress and torment of being confronted and interrogated by them in any court.” Research by charity Women’s Aid suggests a quarter of women in family court proceedings have been cross-examined by an abusive former partner.