(n.) The column of bones in the back which sustains and gives firmness to the frame; the spine; the vertebral or spinal column.
(n.) Anything like , or serving the purpose of, a backbone.
(n.) Firmness; moral principle; steadfastness.
Example Sentences:
(1) A method for the introduction of side chains containing isonitrile (isocyanide, functional group) on the backbone of polysaccharides and other hydroxylic polymers was developed.
(2) The chromophore of octopus rhodopsin is 11-cis retinal, linked via a protonated Schiff base to the protein backbone.
(3) An unprincipled coward with the backbone of an amoeba."
(4) The Pr(III)-induced shifts for several resolved nonexchangeable backbone proton resonances were compared with calculated shifts using the known x-ray structure.
(5) Here we present images of polydeoxyadenylate molecules aligned in parallel, with their bases lying flat on a surface of highly oriented pyrolytic graphite and with their charged phosphodiester backbones protruding upwards.
(6) These data suggest that the somnogenic actions of these lipid A analogs depend on the acylation or phosphorylation pattern and backbone structures of the molecules.
(7) The resulting family of structures has a mean backbone rmsd of 0.63 A (N, C alpha, C', O atoms), excluding the segments containing residues 45-59 and 84-88.
(8) wt polypeptide backbone, modified by an endoglycosidase F-sensitive carbohydrate moiety.
(9) The backbone dynamics of Ca(2+)-saturated recombinant Drosophila calmodulin has been studied by 15N longitudinal and transverse relaxation experiments, combined with 15N(1H) NOE measurements.
(10) A central eight-stranded beta-pleated sheet is the main feature of the polypeptide backbone folding in dihydrofolate reductase.
(11) To investigate the topochemical preference of backbone and side chains, unusual amino acids, including beta-methylphenylalanine7 or 11, beta-methyltryptophan8, as well as backbone modifications such as retro-inverso structures have been incorporated.
(12) The angle obtained for the C alpha-D resonance was consistent with a single-stranded beta 6.3-helical model for the backbone but not with double-helical models.
(13) In the holopeptide corticotropin, the side chain-side chain effects, as reflected by the titration curves obtained from variations in the aromatic region, support the idea of an helical organization of part of the backbone even in aqueous solution.
(14) The local secondary structure was calculated from sequential and medium-range backbone NOEs with the double-iterated Kalman filter method [Altman, R. B., & Jardetzky, O.
(15) Although the (n-h) plots predict the stereochemical possibility of both right-handed and left-handed helices, nucleic acids apparently prefer right-handed conformation because of the energetics associated with the sugar-phosphate backbone and the base.
(16) And 96% of our grants go to African organisations, universities, scientists and small businesses to achieve a single goal: reduce hunger and poverty on our continent by unleashing the potential of the millions of small, family farmers who are the backbone of African agriculture and African economies.
(17) In addition the bare central backbone showed transverse striations.
(18) Misfolded models were constructed by introducing incorrect side chains onto polypeptide backbones: side chains of the alpha-helical hemerythrin were modeled on the beta-sheeted backbone of immunoglobulin VL domain, whereas those of the VL domain were similarly modeled on the hemerythrin backbone.
(19) Complete assignments were obtained for the backbone 1H, 15N and 13C resonances, using three-dimensional heteronuclear 1H NOE 1H-15N multiple-quantum coherence spectroscopy (3D-NOESY-HMQC) and three-dimensional heteronuclear total correlation 1H-15N multiple-quantum coherence spectroscopy (3D-TOCSY-HMQC) experiments on 15N-enriched HPr and an additional three-dimensional triple-resonance 1HN-15N-13C alpha correlation spectroscopy (HNCA) experiment on 13C, 15N-enriched HPr.
(20) Teh presence of the polyglycerol phosphate backbone and fatty acid was required for maximum immunosuppression of the primary immunoglobulin M response to sheep cells.
Fortitude
Definition:
(n.) Power to resist attack; strength; firmness.
(n.) That strength or firmness of mind which enables a person to encounter danger with coolness and courage, or to bear pain or adversity without murmuring, depression, or despondency; passive courage; resolute endurance; firmness in confronting or bearing up against danger or enduring trouble.
Example Sentences:
(1) It has been a season where you learn about yourself, it teaches you about your own mental fortitude and resilience.
(2) I get the frustration and the level of trust that we’ve lost as a result of that incident.” O’Donnell said ABF would continue to conduct checks of immigration status “driven by intelligence” but not in the manner forecast by Operation Fortitude.
(3) So far Greeks have shown remarkable fortitude in the face of such adversity.
(4) Dangerous lists the external threats to American security (the Middle East, North Korea and Islamic State but no Russia, naturally), then accuses Clinton of lacking fortitude with footage of her recent public faint and of her coughing.
(5) Communities in west Africa continue to suffer from the crisis with remarkable fortitude and finally the rich world has committed significant finance and resources to support critical public health measures, and progress in the search for treatments is encouraging.
(6) Jamaican governments haven't been known for their fortitude.
(7) It would send the signal that we did not have the moral resolve and political fortitude to see through what we ourselves have described as a national security imperative."
(8) He said: "There is fortitude and joie de vivre here - the ability to celebrate life in spite of many problems."
(9) The match had not gone as Arsenal had intended, but the fortitude was still memorable.
(10) But 4Children warned that this "impressive fortitude" may not be sustainable in the long run.
(11) Klein helped to nurse her for six months and was inspired by the fortitude and spirit her mother showed in her partial rehabilitation, and the strength she discovered in herself.
(12) "The so-called rebels are very few in number, not substantial and they lack the most critically important feature in democratic politics – what Churchill called intestinal fortitude – guts," Kinnock said.
(13) Even at such a time, even the most deeply bereaved can demonstrate extraordinary fortitude,” he said.
(14) He needed to prove himself; and the real test of both his editorship and fortitude was the Suez crisis of 1956.
(15) He asks for privacy during the next few weeks and he emphasises that he is contrite and faces punishment with fortitude and remorse."
(16) It outlines some of the suffering and distress of having the disorder, some of the efforts and techniques used in trying to understand and cope with the disorder, the fortitude and endurance required, the difficulty in seeking and accepting treatment and some of the sufferer's hopes for a better future.
(17) In the grouping of past-oriented thought,” he says, “nostalgia stands out as adaptive.” In community experiments, research suggests that nostalgia helps build resources like optimism or inspiration or creativity, which are correlated with mental fortitude.
(18) Williams praised the victim’s bravery in coming forward, saying: “She has continued to show courage and fortitude … and the court wishes her good fortune for the future – which she so richly deserves.” Forced marriage was criminalised under the Anti-social Behaviour, Crime and Policing Act 2014, which came into force last June.
(19) So I think just in general, for the group to have the fortitude that they showed to get back to this spot, I think speaks volumes about how they’re constituted and what kind of fibre they have.” It was clear that San Antonio were galvanised by the traumatic nature of their loss to Miami in 2013 - as well as aided by flaccid efforts from Miami's supporting cast, which made the Heat over-reliant on James.
(20) Boys are trained to be more aggressive, show more fortitude, and be more self-reliant than girls; girls are trained to be more industrious, responsible, obedient, and sexually restrained than boys.