(n.) The column of bones in the back which sustains and gives firmness to the frame; the spine; the vertebral or spinal column.
(n.) Anything like , or serving the purpose of, a backbone.
(n.) Firmness; moral principle; steadfastness.
Example Sentences:
(1) A method for the introduction of side chains containing isonitrile (isocyanide, functional group) on the backbone of polysaccharides and other hydroxylic polymers was developed.
(2) The chromophore of octopus rhodopsin is 11-cis retinal, linked via a protonated Schiff base to the protein backbone.
(3) An unprincipled coward with the backbone of an amoeba."
(4) The Pr(III)-induced shifts for several resolved nonexchangeable backbone proton resonances were compared with calculated shifts using the known x-ray structure.
(5) Here we present images of polydeoxyadenylate molecules aligned in parallel, with their bases lying flat on a surface of highly oriented pyrolytic graphite and with their charged phosphodiester backbones protruding upwards.
(6) These data suggest that the somnogenic actions of these lipid A analogs depend on the acylation or phosphorylation pattern and backbone structures of the molecules.
(7) The resulting family of structures has a mean backbone rmsd of 0.63 A (N, C alpha, C', O atoms), excluding the segments containing residues 45-59 and 84-88.
(8) wt polypeptide backbone, modified by an endoglycosidase F-sensitive carbohydrate moiety.
(9) The backbone dynamics of Ca(2+)-saturated recombinant Drosophila calmodulin has been studied by 15N longitudinal and transverse relaxation experiments, combined with 15N(1H) NOE measurements.
(10) A central eight-stranded beta-pleated sheet is the main feature of the polypeptide backbone folding in dihydrofolate reductase.
(11) To investigate the topochemical preference of backbone and side chains, unusual amino acids, including beta-methylphenylalanine7 or 11, beta-methyltryptophan8, as well as backbone modifications such as retro-inverso structures have been incorporated.
(12) The angle obtained for the C alpha-D resonance was consistent with a single-stranded beta 6.3-helical model for the backbone but not with double-helical models.
(13) In the holopeptide corticotropin, the side chain-side chain effects, as reflected by the titration curves obtained from variations in the aromatic region, support the idea of an helical organization of part of the backbone even in aqueous solution.
(14) The local secondary structure was calculated from sequential and medium-range backbone NOEs with the double-iterated Kalman filter method [Altman, R. B., & Jardetzky, O.
(15) Although the (n-h) plots predict the stereochemical possibility of both right-handed and left-handed helices, nucleic acids apparently prefer right-handed conformation because of the energetics associated with the sugar-phosphate backbone and the base.
(16) And 96% of our grants go to African organisations, universities, scientists and small businesses to achieve a single goal: reduce hunger and poverty on our continent by unleashing the potential of the millions of small, family farmers who are the backbone of African agriculture and African economies.
(17) In addition the bare central backbone showed transverse striations.
(18) Misfolded models were constructed by introducing incorrect side chains onto polypeptide backbones: side chains of the alpha-helical hemerythrin were modeled on the beta-sheeted backbone of immunoglobulin VL domain, whereas those of the VL domain were similarly modeled on the hemerythrin backbone.
(19) Complete assignments were obtained for the backbone 1H, 15N and 13C resonances, using three-dimensional heteronuclear 1H NOE 1H-15N multiple-quantum coherence spectroscopy (3D-NOESY-HMQC) and three-dimensional heteronuclear total correlation 1H-15N multiple-quantum coherence spectroscopy (3D-TOCSY-HMQC) experiments on 15N-enriched HPr and an additional three-dimensional triple-resonance 1HN-15N-13C alpha correlation spectroscopy (HNCA) experiment on 13C, 15N-enriched HPr.
(20) Teh presence of the polyglycerol phosphate backbone and fatty acid was required for maximum immunosuppression of the primary immunoglobulin M response to sheep cells.
Grit
Definition:
(n.) Sand or gravel; rough, hard particles.
(n.) The coarse part of meal.
(n.) Grain, esp. oats or wheat, hulled and coarsely ground; in high milling, fragments of cracked wheat smaller than groats.
(n.) A hard, coarse-grained siliceous sandstone; as, millstone grit; -- called also gritrock and gritstone. The name is also applied to a finer sharp-grained sandstone; as, grindstone grit.
(n.) Structure, as adapted to grind or sharpen; as, a hone of good grit.
(n.) Firmness of mind; invincible spirit; unyielding courage; fortitude.
(v. i.) To give forth a grating sound, as sand under the feet; to grate; to grind.
(v. t.) To grind; to rub harshly together; to grate; as, to grit the teeth.
Example Sentences:
(1) Distribution of polychlorinated biphenyls (PCB) in sewage wastes at a municipal sewage treatment plant was studied, showing that the great bulk of PCBs entering such a treatment plant become adsorbed onto the grit chamber solids and the sludge that is passed from the anaerobic digesters.
(2) We suggest that other functions than grinding, such as supplying minerals, may be equally important functions of the grit.
(3) A lesser amount of toxin was produced on rice, but none was detected in wheat incubated at 20 C. The amount of toxin measured in white corn grits declined as the incubation temperature was raised to 20, 25, and 32 C.
(4) The notion that Gleeson has lurched from one disaster to another, ruining everything from the Coen brothers' remake of True Grit to Richard Curtis's romcom About Time , seems a pretty unique interpretation of his burgeoning career as a versatile character actor.
(5) For that matter, mulching with bark, grit or slate will help keep the surface roots cooler and retain moisture in hot weather.
(6) The effect of different modes of the hydrothermal treatment of buckwheat and of the grit cooking on a change in the composition of sterols and phospholipids was investigated.
(7) Chrysler aired a commercial during the Super Bowl declaring its cars were “imported from Detroit,” playing upon the city’s grit and determination to sell cars we barely made.
(8) She shares her conflicted instincts, the personal frustration, the gritted teeth effort to stay afloat when the team was coming apart ... a declaration a lot of women will recognise: “I felt I could hold things together.” The eventual decision that the show could no longer stay afloat.
(9) Days when the only thing to do is to grit one’s teeth and force oneself to think different thoughts.
(10) The diamond fraise is a more exacting instrument and with the recent introduction of the extra-coarse grit diamond fraise, the instrument is as abrasive as the standard wire brush.
(11) For me, Kitson is at his best when ( as the New York Times said of It's Always Right Now) "he seasons the treacle with grit".
(12) There is still a grit to the brand but it’s been refined, in a natural kind of a way, because now I’m 31, not 21, so there are things I didn’t like before that I like now; things I liked before and now want a better version of.
(13) Sixteen cured samples of each were initially finished with 600-grit paper and then abraded by medium-grit wheels for 30,000 cycles.
(14) We're told that Cameron wanted to create a highly political Thatcher-style policy unit to provide intellectual grit and better communication.
(15) I grit my teeth as the trees hunker down smaller and smaller, then finally give up entirely, leaving us alone in a barren upland area where there is one large grey house partially obscured by torn curtains of freezing rain.
(16) Immediately before being bonded, the amalgam surfaces were finished flat on 600-grit paper.
(17) As burly security men hung back and the promoters sat silently by, Chisora marched on Haye, who gritted his teeth, held on to what those close to him say was a bottle of Desperados, a pale German lager tinged with tequila, and threw an inspired right hand that cracked into the side of Chisora's jaw.
(18) Data are presented for three different grades (400, 500 and 600 grit) of commercially available emory paper and three samples of osteoarthritic femoral head articular cartilage, which were visually assessed as having smooth, intermediate and rough surfaces, respectively.
(19) Set in recession-hit small town America, Gone Girl is a mystery of grit and steel.
(20) It takes grit and it takes grace.” Placing Clinton in a lineage of great American women from Rosa Parks and Amelia Earhart to Harriet Tubman and Eleanor Roosevelt, she told the delegates: “You people have made history and you’re gonna make history again in November because Hillary Clinton will be our first woman president … she’ll be the first but she won’t be the last.” Lena Dunham, creator and star of the HBO series Girls, led a series of celebrity endorsements that joined the dots between Clinton’s breaking of glass ceilings and Trump’s dismissive comments about women.