(n.) The column of bones in the back which sustains and gives firmness to the frame; the spine; the vertebral or spinal column.
(n.) Anything like , or serving the purpose of, a backbone.
(n.) Firmness; moral principle; steadfastness.
Example Sentences:
(1) A method for the introduction of side chains containing isonitrile (isocyanide, functional group) on the backbone of polysaccharides and other hydroxylic polymers was developed.
(2) The chromophore of octopus rhodopsin is 11-cis retinal, linked via a protonated Schiff base to the protein backbone.
(3) An unprincipled coward with the backbone of an amoeba."
(4) The Pr(III)-induced shifts for several resolved nonexchangeable backbone proton resonances were compared with calculated shifts using the known x-ray structure.
(5) Here we present images of polydeoxyadenylate molecules aligned in parallel, with their bases lying flat on a surface of highly oriented pyrolytic graphite and with their charged phosphodiester backbones protruding upwards.
(6) These data suggest that the somnogenic actions of these lipid A analogs depend on the acylation or phosphorylation pattern and backbone structures of the molecules.
(7) The resulting family of structures has a mean backbone rmsd of 0.63 A (N, C alpha, C', O atoms), excluding the segments containing residues 45-59 and 84-88.
(8) wt polypeptide backbone, modified by an endoglycosidase F-sensitive carbohydrate moiety.
(9) The backbone dynamics of Ca(2+)-saturated recombinant Drosophila calmodulin has been studied by 15N longitudinal and transverse relaxation experiments, combined with 15N(1H) NOE measurements.
(10) A central eight-stranded beta-pleated sheet is the main feature of the polypeptide backbone folding in dihydrofolate reductase.
(11) To investigate the topochemical preference of backbone and side chains, unusual amino acids, including beta-methylphenylalanine7 or 11, beta-methyltryptophan8, as well as backbone modifications such as retro-inverso structures have been incorporated.
(12) The angle obtained for the C alpha-D resonance was consistent with a single-stranded beta 6.3-helical model for the backbone but not with double-helical models.
(13) In the holopeptide corticotropin, the side chain-side chain effects, as reflected by the titration curves obtained from variations in the aromatic region, support the idea of an helical organization of part of the backbone even in aqueous solution.
(14) The local secondary structure was calculated from sequential and medium-range backbone NOEs with the double-iterated Kalman filter method [Altman, R. B., & Jardetzky, O.
(15) Although the (n-h) plots predict the stereochemical possibility of both right-handed and left-handed helices, nucleic acids apparently prefer right-handed conformation because of the energetics associated with the sugar-phosphate backbone and the base.
(16) And 96% of our grants go to African organisations, universities, scientists and small businesses to achieve a single goal: reduce hunger and poverty on our continent by unleashing the potential of the millions of small, family farmers who are the backbone of African agriculture and African economies.
(17) In addition the bare central backbone showed transverse striations.
(18) Misfolded models were constructed by introducing incorrect side chains onto polypeptide backbones: side chains of the alpha-helical hemerythrin were modeled on the beta-sheeted backbone of immunoglobulin VL domain, whereas those of the VL domain were similarly modeled on the hemerythrin backbone.
(19) Complete assignments were obtained for the backbone 1H, 15N and 13C resonances, using three-dimensional heteronuclear 1H NOE 1H-15N multiple-quantum coherence spectroscopy (3D-NOESY-HMQC) and three-dimensional heteronuclear total correlation 1H-15N multiple-quantum coherence spectroscopy (3D-TOCSY-HMQC) experiments on 15N-enriched HPr and an additional three-dimensional triple-resonance 1HN-15N-13C alpha correlation spectroscopy (HNCA) experiment on 13C, 15N-enriched HPr.
(20) Teh presence of the polyglycerol phosphate backbone and fatty acid was required for maximum immunosuppression of the primary immunoglobulin M response to sheep cells.
Gumption
Definition:
(n.) Capacity; shrewdness; common sense.
(n.) The art of preparing colors.
(n.) Megilp.
Example Sentences:
(1) It’s not just a matter of will or gumption or desire on my part.
(2) The other lumped the ball forward with neither the wit nor gumption to get behind the opposition defence on a single occasion.
(3) It will blitz much of London's south Camden because decades ago a rail planner thought businessmen deserved a more comfortable trip to Euston, and no one had the gumption to think otherwise.
(4) "When I look back on it now, I wish we had the gumption or the knowledge to realise at a very early stage that Fifa wanted something fundamentally different than what we were putting on the table," the minister said.
(5) His front players simply did not have the wit or gumption to examine whether City, without Kompany, might be at risk.
(6) In a city of hustlers, tricksters, and go-getters, where the right dose of swag and gumption gets you farther than a college degree can, Furo is a bumbling non-entity.
(7) Yet they played with a level of wit and gumption that has become rare among visiting teams to this ground.
(8) Unfortunately for England, they did not have the wit or gumption to do anything about it.
(9) Soames said: "If the Press Complaints Commission had any gumption or mettle … we would not need to refer this matter to the select committee."
(10) Rid them from our small island, came the still popular reply, especially those with the gumption to organise others.
(11) Quitting can show coworkers or colleagues who don’t quite have the gumption to get out of obviously bad situations that it can be done; it can inspire others to have the courage to change their lot, maybe in less brazen, more incremental ways.
(12) Is his bossness inherent, or is it something that I or anybody else could achieve with a little bit of gumption and a lot of front?
(13) Why did Labour here not have the guts and the gumption to do the same thing when it had the chance.
(14) Manchester City stay top after late drama against Norwich City Read more Wenger’s team were beaten twice by Swansea last season and gaining vengeance, especially amid an injury crisis, is the sort of achievement that gives credence to suggestions that Arsenal may finally have the gumption to become champions once again.
(15) President Peña-Nieto has the gumption to ask the Egyptian government this week “to perform an exhaustive investigation” looking into the reasons why Egyptian forces air raided and killed twelve tourists, eight of which were Mexican nationals, after allegedly mistaking them for terrorists.
(16) There were weaknesses in the prosecution case: no forensic evidence to link Matthews to Shannon's flat prison, and doubts that Donovan – described as "soft-headed" and "a weirdo" by neighbours – had the gumption to carry out a kidnap.
(17) Walters has been written off before, towards the end of Pulis’s reign, and came back strongly, endearing himself even further to Stoke fans, who are particularly reluctant to vent against ageing wingers, what with there being a statue outside their ground of Sir Stanley Matthews, who played for them until just after his 50th birthday and later declared: “It was a mistake to pack it in, I could have gone on for another two years.” If sheer gumption were enough for a player to play until his 50s, then Walters would be a good bet to make it.
(18) He has said his show is only necessary because journalists have abandoned their responsibilities through a mix of indifference and a lack of gumption that leaves viewers and readers with no real idea of what is going on.
(19) Microfinance became a powerful way of casting the poor as responsible for bootstrapping themselves out of poverty: all you need is a bit of gumption and some credit, and you should do just fine – if you fail, you have no one to blame but yourself.
(20) And hopefuly labour will have the gumption to remind them.