(n.) The column of bones in the back which sustains and gives firmness to the frame; the spine; the vertebral or spinal column.
(n.) Anything like , or serving the purpose of, a backbone.
(n.) Firmness; moral principle; steadfastness.
Example Sentences:
(1) A method for the introduction of side chains containing isonitrile (isocyanide, functional group) on the backbone of polysaccharides and other hydroxylic polymers was developed.
(2) The chromophore of octopus rhodopsin is 11-cis retinal, linked via a protonated Schiff base to the protein backbone.
(3) An unprincipled coward with the backbone of an amoeba."
(4) The Pr(III)-induced shifts for several resolved nonexchangeable backbone proton resonances were compared with calculated shifts using the known x-ray structure.
(5) Here we present images of polydeoxyadenylate molecules aligned in parallel, with their bases lying flat on a surface of highly oriented pyrolytic graphite and with their charged phosphodiester backbones protruding upwards.
(6) These data suggest that the somnogenic actions of these lipid A analogs depend on the acylation or phosphorylation pattern and backbone structures of the molecules.
(7) The resulting family of structures has a mean backbone rmsd of 0.63 A (N, C alpha, C', O atoms), excluding the segments containing residues 45-59 and 84-88.
(8) wt polypeptide backbone, modified by an endoglycosidase F-sensitive carbohydrate moiety.
(9) The backbone dynamics of Ca(2+)-saturated recombinant Drosophila calmodulin has been studied by 15N longitudinal and transverse relaxation experiments, combined with 15N(1H) NOE measurements.
(10) A central eight-stranded beta-pleated sheet is the main feature of the polypeptide backbone folding in dihydrofolate reductase.
(11) To investigate the topochemical preference of backbone and side chains, unusual amino acids, including beta-methylphenylalanine7 or 11, beta-methyltryptophan8, as well as backbone modifications such as retro-inverso structures have been incorporated.
(12) The angle obtained for the C alpha-D resonance was consistent with a single-stranded beta 6.3-helical model for the backbone but not with double-helical models.
(13) In the holopeptide corticotropin, the side chain-side chain effects, as reflected by the titration curves obtained from variations in the aromatic region, support the idea of an helical organization of part of the backbone even in aqueous solution.
(14) The local secondary structure was calculated from sequential and medium-range backbone NOEs with the double-iterated Kalman filter method [Altman, R. B., & Jardetzky, O.
(15) Although the (n-h) plots predict the stereochemical possibility of both right-handed and left-handed helices, nucleic acids apparently prefer right-handed conformation because of the energetics associated with the sugar-phosphate backbone and the base.
(16) And 96% of our grants go to African organisations, universities, scientists and small businesses to achieve a single goal: reduce hunger and poverty on our continent by unleashing the potential of the millions of small, family farmers who are the backbone of African agriculture and African economies.
(17) In addition the bare central backbone showed transverse striations.
(18) Misfolded models were constructed by introducing incorrect side chains onto polypeptide backbones: side chains of the alpha-helical hemerythrin were modeled on the beta-sheeted backbone of immunoglobulin VL domain, whereas those of the VL domain were similarly modeled on the hemerythrin backbone.
(19) Complete assignments were obtained for the backbone 1H, 15N and 13C resonances, using three-dimensional heteronuclear 1H NOE 1H-15N multiple-quantum coherence spectroscopy (3D-NOESY-HMQC) and three-dimensional heteronuclear total correlation 1H-15N multiple-quantum coherence spectroscopy (3D-TOCSY-HMQC) experiments on 15N-enriched HPr and an additional three-dimensional triple-resonance 1HN-15N-13C alpha correlation spectroscopy (HNCA) experiment on 13C, 15N-enriched HPr.
(20) Teh presence of the polyglycerol phosphate backbone and fatty acid was required for maximum immunosuppression of the primary immunoglobulin M response to sheep cells.
Mainstay
Definition:
(n.) The stay extending from the foot of the foremast to the maintop.
(n.) Main support; principal dependence.
Example Sentences:
(1) Diuretics remain the mainstay of therapy for most hypertensive black patients.
(2) Surgery must be considered the mainstay of therapy for fibrosarcoma, but there is a need for adjunctive therapy.
(3) Although Burkitt's lymphoma (BL) can be treated by surgery, radiotherapy and immunotherapy, chemotherapy is the mainstay of treatment.
(4) Aggressive therapy with intravenous fluids and potassium and the judicious use of insulin, in conjunction with careful monitoring of central venous pressure and urine output, form the mainstays of treatment.
(5) CT is now the mainstay of diagnosis for stable patients with blunt hepatic injuries.
(6) Lubricants, anthralin, and corticosteroids form the mainstay of therapy in mild and moderate psoriasis of the palms and soles.
(7) Lithium remains the mainstay of pharmacologic therapy for the majority of patients with bipolar disorder; however, significant numbers of patients with both classical bipolar disorder and syndromal variants fail to respond to lithium therapy.
(8) Consequently, digoxin remains the mainstay for chronic inotropic support of the heart.
(9) Heparin is the mainstay of treatment for deep venous thrombosis and pulmonary embolism, with an important role played by warfarin therapy.
(10) Plain radiography remains the mainstay of diagnosis of vertebral injuries.
(11) Radiation rather than surgery has been the mainstay of treatment for intracranial tumors of the optic pathway.
(12) The mainstay of pain relief is effective use of analgetics which should be given orally if possible, on a regular schedule and on an individualized basis according with the WHO guidelines.
(13) The mainstays of therapy include motivation, meticulous physical and laboratory evaluation, abstinence, and support during withdrawal.
(14) Although combination antibiotic therapy and correct postoperative wound management are potentially successful, the mainstay of treatment is complete excision of all necrotic tissue.
(15) Pelviscopy, along with the entire concept of minimally invasive surgery through endoscopically guided intra-abdominal surgery, has become a mainstay in gynecologic surgery.
(16) Contact was made with a ‘mystical-religious’ group that used the gas to accelerate arriving at their transcendental-meditative state of choice.” It increased in popularity with the rise of festival culture – it’s been a mainstay of Glastonbury’s stone circle and squat parties in Bristol and south London for at least a decade – but the equipment needed to dispense it remained relatively expensive.
(17) Antipsychotic medication remains a mainstay of treatment in both acute and chronic schizophrenia.
(18) In all cases, even when corticosteroids are the mainstay of maintenance treatment, bronchodilators must be used simultaneously.
(19) For many centuries antacids have been the mainstay of treatment of peptic disorders.
(20) The mainstays of treatment are life-style changes to avoid overexertion and use of light-weight orthoses and assistive aids to unload the extremities.