(n.) The column of bones in the back which sustains and gives firmness to the frame; the spine; the vertebral or spinal column.
(n.) Anything like , or serving the purpose of, a backbone.
(n.) Firmness; moral principle; steadfastness.
Example Sentences:
(1) A method for the introduction of side chains containing isonitrile (isocyanide, functional group) on the backbone of polysaccharides and other hydroxylic polymers was developed.
(2) The chromophore of octopus rhodopsin is 11-cis retinal, linked via a protonated Schiff base to the protein backbone.
(3) An unprincipled coward with the backbone of an amoeba."
(4) The Pr(III)-induced shifts for several resolved nonexchangeable backbone proton resonances were compared with calculated shifts using the known x-ray structure.
(5) Here we present images of polydeoxyadenylate molecules aligned in parallel, with their bases lying flat on a surface of highly oriented pyrolytic graphite and with their charged phosphodiester backbones protruding upwards.
(6) These data suggest that the somnogenic actions of these lipid A analogs depend on the acylation or phosphorylation pattern and backbone structures of the molecules.
(7) The resulting family of structures has a mean backbone rmsd of 0.63 A (N, C alpha, C', O atoms), excluding the segments containing residues 45-59 and 84-88.
(8) wt polypeptide backbone, modified by an endoglycosidase F-sensitive carbohydrate moiety.
(9) The backbone dynamics of Ca(2+)-saturated recombinant Drosophila calmodulin has been studied by 15N longitudinal and transverse relaxation experiments, combined with 15N(1H) NOE measurements.
(10) A central eight-stranded beta-pleated sheet is the main feature of the polypeptide backbone folding in dihydrofolate reductase.
(11) To investigate the topochemical preference of backbone and side chains, unusual amino acids, including beta-methylphenylalanine7 or 11, beta-methyltryptophan8, as well as backbone modifications such as retro-inverso structures have been incorporated.
(12) The angle obtained for the C alpha-D resonance was consistent with a single-stranded beta 6.3-helical model for the backbone but not with double-helical models.
(13) In the holopeptide corticotropin, the side chain-side chain effects, as reflected by the titration curves obtained from variations in the aromatic region, support the idea of an helical organization of part of the backbone even in aqueous solution.
(14) The local secondary structure was calculated from sequential and medium-range backbone NOEs with the double-iterated Kalman filter method [Altman, R. B., & Jardetzky, O.
(15) Although the (n-h) plots predict the stereochemical possibility of both right-handed and left-handed helices, nucleic acids apparently prefer right-handed conformation because of the energetics associated with the sugar-phosphate backbone and the base.
(16) And 96% of our grants go to African organisations, universities, scientists and small businesses to achieve a single goal: reduce hunger and poverty on our continent by unleashing the potential of the millions of small, family farmers who are the backbone of African agriculture and African economies.
(17) In addition the bare central backbone showed transverse striations.
(18) Misfolded models were constructed by introducing incorrect side chains onto polypeptide backbones: side chains of the alpha-helical hemerythrin were modeled on the beta-sheeted backbone of immunoglobulin VL domain, whereas those of the VL domain were similarly modeled on the hemerythrin backbone.
(19) Complete assignments were obtained for the backbone 1H, 15N and 13C resonances, using three-dimensional heteronuclear 1H NOE 1H-15N multiple-quantum coherence spectroscopy (3D-NOESY-HMQC) and three-dimensional heteronuclear total correlation 1H-15N multiple-quantum coherence spectroscopy (3D-TOCSY-HMQC) experiments on 15N-enriched HPr and an additional three-dimensional triple-resonance 1HN-15N-13C alpha correlation spectroscopy (HNCA) experiment on 13C, 15N-enriched HPr.
(20) Teh presence of the polyglycerol phosphate backbone and fatty acid was required for maximum immunosuppression of the primary immunoglobulin M response to sheep cells.
Saddle
Definition:
(n.) A seat for a rider, -- usually made of leather, padded to span comfortably a horse's back, furnished with stirrups for the rider's feet to rest in, and fastened in place with a girth; also, a seat for the rider on a bicycle or tricycle.
(n.) A padded part of a harness which is worn on a horse's back, being fastened in place with a girth. It serves various purposes, as to keep the breeching in place, carry guides for the reins, etc.
(n.) A piece of meat containing a part of the backbone of an animal with the ribs on each side; as, a saddle of mutton, of venison, etc.
(n.) A block of wood, usually fastened to some spar, and shaped to receive the end of another spar.
(n.) A part, as a flange, which is hollowed out to fit upon a convex surface and serve as a means of attachment or support.
(n.) The clitellus of an earthworm.
(n.) The threshold of a door, when a separate piece from the floor or landing; -- so called because it spans and covers the joint between two floors.
(v. t.) To put a saddle upon; to equip (a beast) for riding.
(v. t.) Hence: To fix as a charge or burden upon; to load; to encumber; as, to saddle a town with the expense of bridges and highways.
Example Sentences:
(1) Based on our experience with the mark I prosthesis we have designed and developed a mark II model which has freedom of axial rotation of the saddle.
(2) Joaquin Rodriguez Oliver is amusing himself by trying to take a puff of a cigar in his saddle.
(3) To date, 3-dimensional studies have demonstrated that the mitral valve is saddle-shaped in systole, so that apparent superior leaflet displacement in the mediolateral 4-chamber view, often seen in otherwise normal individuals, lies entirely within the bounds defined by the mitral annulus and occurs without leaflet distortion or actual displacement above the entire mitral valve.
(4) Devitalized homologous costal cartilage is widely employed as an implant in the management of the saddle nose.
(5) Our practice of initiating treatment of saddle embolism with immediate systemic heparin infusion resembles that of Blaisdell et al.
(6) Charlize Theron is set to star opposite Seth MacFarlane in the Ted creator's new comedy western A Million Ways to Die in the West, tipped as a homage to Mel Brooks's classic movie Blazing Saddles .
(7) Eleven patients with stones overlying the sacro-iliac joint were treated in the prone position, while 56 patients with stones distal to the sacro-iliac joint, were treated in the saddle (astride) position.
(8) Proteins of normal serum as well as induced serum emerged in two peaks separated by a deep saddle.
(9) In the Russian gallery, for example, the courageous Vadim Zakharov presents a pointed version of the Danaë myth in which an insouciant dictator (of whom it is hard not to think: Putin) sits on a high beam on a saddle, shelling nuts all day while gold coins rain down from a vast shower-head only to be hoisted in buckets by faceless thuggish men in suits.
(10) Serious septal injuries may include comminuted caudal border fractures, septal crushes, and saddling with loss of septal height.
(11) For the saddle coil, signal-to-noise per pixel was superior to the head coil for depths below 8.5 cm for magnifications up to 30%.
(12) But they also saddled governments with large deficits, which soon came to be viewed as an obstacle to recovery – the opposite of what Keynes taught.
(13) Correction of the saddle nasal deformity requires generous elevation and mobilization of the overlying soft tissue, the restoration of skeletal support, and the provision of nasal mucosa lining ("the forgotten link").
(14) The patient showed characteristic features: upper and lower eyelids connected to each other by a string-like epithelium, low hairline, epicanthal folds, saddle nose with a broad, flat root, micrognathia, short neck, high-arched palate, prominent xiphisternum, wide-spaced nipples, bilateral pes equinovarus, fifth toes that overlapped the fourth toes bilaterally, a deep fissure between the first and second toes bilaterally, and abnormal flexions of fingers and toes.
(15) Murdoch’s humblest day didn’t last long, with Rebekah Brooks back in the saddle an James Murdoch back in charge of Sky and angling to take over the whole company.
(16) High-resolution magnetic resonance (MR) images of the skin were acquired with a whole-body MR system at 1.5 T by adding a specific imaging module: A saddle-shaped surface gradient coil was connected in place of one of the gradient coils of the system, and a surface radio-frequency coil with a 1.5-cm radius was placed at the center of the gradient coil.
(17) Other clinical manifestations were saddle nose (3 cases), painful swelling of ear (2 cases), arthralgia (1 case) ophthalmodynia (1 case).
(18) While traditional causes of occlusion (saddle embolus and thrombosis) are the most frequent, vasculitis and hypercoagulable states have recently been suggested as etiologies.
(19) The equipment consisted of a sound transducer applied to the skin adjacent to the trachea and a radio transmitter attached to the saddle.
(20) Successively: correction of the dorsum (resection of the bony hump) with incorrect nasofrontal angle, residual hump, "saddle nose"; lateral osteotomy and bony step; transversal and paramedian osteotomy with possibility of "open roof" so as residual deviation.