(n.) The column of bones in the back which sustains and gives firmness to the frame; the spine; the vertebral or spinal column.
(n.) Anything like , or serving the purpose of, a backbone.
(n.) Firmness; moral principle; steadfastness.
Example Sentences:
(1) A method for the introduction of side chains containing isonitrile (isocyanide, functional group) on the backbone of polysaccharides and other hydroxylic polymers was developed.
(2) The chromophore of octopus rhodopsin is 11-cis retinal, linked via a protonated Schiff base to the protein backbone.
(3) An unprincipled coward with the backbone of an amoeba."
(4) The Pr(III)-induced shifts for several resolved nonexchangeable backbone proton resonances were compared with calculated shifts using the known x-ray structure.
(5) Here we present images of polydeoxyadenylate molecules aligned in parallel, with their bases lying flat on a surface of highly oriented pyrolytic graphite and with their charged phosphodiester backbones protruding upwards.
(6) These data suggest that the somnogenic actions of these lipid A analogs depend on the acylation or phosphorylation pattern and backbone structures of the molecules.
(7) The resulting family of structures has a mean backbone rmsd of 0.63 A (N, C alpha, C', O atoms), excluding the segments containing residues 45-59 and 84-88.
(8) wt polypeptide backbone, modified by an endoglycosidase F-sensitive carbohydrate moiety.
(9) The backbone dynamics of Ca(2+)-saturated recombinant Drosophila calmodulin has been studied by 15N longitudinal and transverse relaxation experiments, combined with 15N(1H) NOE measurements.
(10) A central eight-stranded beta-pleated sheet is the main feature of the polypeptide backbone folding in dihydrofolate reductase.
(11) To investigate the topochemical preference of backbone and side chains, unusual amino acids, including beta-methylphenylalanine7 or 11, beta-methyltryptophan8, as well as backbone modifications such as retro-inverso structures have been incorporated.
(12) The angle obtained for the C alpha-D resonance was consistent with a single-stranded beta 6.3-helical model for the backbone but not with double-helical models.
(13) In the holopeptide corticotropin, the side chain-side chain effects, as reflected by the titration curves obtained from variations in the aromatic region, support the idea of an helical organization of part of the backbone even in aqueous solution.
(14) The local secondary structure was calculated from sequential and medium-range backbone NOEs with the double-iterated Kalman filter method [Altman, R. B., & Jardetzky, O.
(15) Although the (n-h) plots predict the stereochemical possibility of both right-handed and left-handed helices, nucleic acids apparently prefer right-handed conformation because of the energetics associated with the sugar-phosphate backbone and the base.
(16) And 96% of our grants go to African organisations, universities, scientists and small businesses to achieve a single goal: reduce hunger and poverty on our continent by unleashing the potential of the millions of small, family farmers who are the backbone of African agriculture and African economies.
(17) In addition the bare central backbone showed transverse striations.
(18) Misfolded models were constructed by introducing incorrect side chains onto polypeptide backbones: side chains of the alpha-helical hemerythrin were modeled on the beta-sheeted backbone of immunoglobulin VL domain, whereas those of the VL domain were similarly modeled on the hemerythrin backbone.
(19) Complete assignments were obtained for the backbone 1H, 15N and 13C resonances, using three-dimensional heteronuclear 1H NOE 1H-15N multiple-quantum coherence spectroscopy (3D-NOESY-HMQC) and three-dimensional heteronuclear total correlation 1H-15N multiple-quantum coherence spectroscopy (3D-TOCSY-HMQC) experiments on 15N-enriched HPr and an additional three-dimensional triple-resonance 1HN-15N-13C alpha correlation spectroscopy (HNCA) experiment on 13C, 15N-enriched HPr.
(20) Teh presence of the polyglycerol phosphate backbone and fatty acid was required for maximum immunosuppression of the primary immunoglobulin M response to sheep cells.
Skeleton
Definition:
(n.) The bony and cartilaginous framework which supports the soft parts of a vertebrate animal.
(n.) The more or less firm or hardened framework of an invertebrate animal.
(n.) A very thin or lean person.
(n.) The framework of anything; the principal parts that support the rest, but without the appendages.
(n.) The heads and outline of a literary production, especially of a sermon.
(a.) Consisting of, or resembling, a skeleton; consisting merely of the framework or outlines; having only certain leading features of anything; as, a skeleton sermon; a skeleton crystal.
Example Sentences:
(1) Since all human cadaveric tissue is fixed whilst on the skeleton, we may assume that shrinkage of the muscles in such specimens is negligible.
(2) This result indicates that the bone marrow is a very useful material for the detection of diazepam in skeletonized remains.
(3) Dysplasia epiphysealis hemimelica - an epiphyseal developmental disturbance of the skeleton - is combined with exostose-like, tumor-simulating cartilaginous hypertrophy of bone tissue, mainly located at the epiphyses of the lower extremities and at the tarsal bones.
(4) Hypertrophic osteoarthropathy (HOA) was first described in 1868 as "hyperostosis of the entire skeleton".
(5) The alveolar stability requires particular properties of both the fibrous skeleton and the alveolar surfactant film.
(6) Heart- lung- and skeleton examinations remain unchanged, and represent 71 to 79% of the total number, but there has been a marked charge in other examinations.
(7) In one horse, the superior aspect of the right ascending ramus of the lower jaw below the coronoid process revealed a gunshot wound; the other skeletons showed no evidence of trauma.
(8) In support of this argument, a case of erosive arthritis is reported in a skeleton from Kulubnarti, Republic of the Sudan (c. 700-1450 A.D.).
(9) The author describes three systems for (1) the treatment of mandibular fractures; (2) the treatment of midface fractures, for reconstructive surgery of the facial skeleton and the skull, and for orthognathic surgery; and (3) the reconstruction of mandibular defects including condyle replacement.
(10) The abnormalities described might bear some relation to the densification of the skeleton seen in pycnodysostosis.
(11) The participation of neural crest cells in development of the dermal skeleton is discussed by way of the repartition of the odontods within the pectoral fin.
(12) This malformation was demonstrated in alcian-blue- and alizarin-red-stained fetal skeletons by measurements of the distance between the cartilaginous ends of each vertebral arch.
(13) A study was undertaken to assess whether CT measurements of the upper craniofacial skeleton accurately represent the bony region imaged.
(14) The destabilization of the red cell membrane skeleton in the presence of crude iHCR is caused by release of hemin, which lowers the stability of membrane skeleton by weakening the spectrin-protein 4.1-actin interaction.
(15) These data suggest that the main route for the formation of the carbon skeleton of aspartate was by a C(3) plus C(1) condensation, with the C(3) unit derived from the isopropyl carbons of valine and the C(1) unit probably from carbon dioxide.
(16) Nevertheless, the band 3 population solubilized by Triton X-100 from prelabeled ghosts was as well phosphorylated as the population of band 3 retained by the skeletons.
(17) Seventy-seven patients with metastases confined to skeleton and 73 patients bearing visceral-only disease were identified.
(18) The authors describe the maternal transport and delivery of a neonate with a serious disorder that required specialized attention at an hour when most hospitals are staffed with a skeleton crew.
(19) (2) It is suggested that the boundaries of the bipolar limb system lie in the girdle skeleton and at the distal end of the limb, respectively, and that it is the apical epidermis of the growing or regenerating limb which defines the distal boundary conditions.
(20) In 12 patients with neurofibromatosis of the maxillofacial region distinct changes of the facial skeleton were found, which in localisation and extent largely conformed to the more or less wide soft tissue hyperplasias.