(n.) The foundation of anything; that on which a thing rests.
(n.) The pedestal of a column, pillar, or statue.
(n.) The ground work the first or fundamental principle; that which supports.
(n.) The principal component part of a thing.
Example Sentences:
(1) Arachidic acid was without effect, while linoleic acid and linolenic acid were (on a concentration basis) at least 5-times less active than arachidonic acid.
(2) The combined analysis of pathogenesis and genetics associated with the salmonella virulence plasmids may identify new systems of bacterial virulence and the genetic basis for this virulence.
(3) On the basis of 180 interventions, they describe in detail the use of fibrin glue in myringo- and tympanoplasty for correct fixing of grafts.
(4) For the first time it was organized on the basis of population.
(5) The purpose of these studies was to better understand the molecular basis of chromosome aberration formation after mitomycin C treatment.
(6) Acquired drug resistance to INH, RMP, and EMB can be demonstrated in M. kansasii, and SMX in combination with other agents chosen on the basis of MIC determinations are effective in the treatment of disease caused by RMP-resistant M. kansasii.
(7) A novel prostaglandin E2 analogue, CL 115347, can be administered transdermally on a long-term basis.
(8) In this phase the educational practices are vastly determined by individual activities which form the basis for later regulations by the state.
(9) The structures of 1 and 2 were established mainly on the basis of nmr spectroscopic data.
(10) Determination of the primary structure for factor V has provided the basis for examination of structure-function relationships.
(11) The Bohr and Root effects are absent, although specific amino acid residues, considered responsible of most of these functions, are conserved in the sequence, thus posing new questions about the molecular basis of these mechanisms.
(12) On the basis of obtained data on the uniformity of chemical compounds of the secretion of glands belonging to different groups their common origin has been suggested.
(13) The stepped approach is cost-effective and provides an objective basis for decisions and priority setting.
(14) On the basis of primary sequence homology with other known Pseudomonas lipases, a number of putative active site residues located in conserved areas were found.
(15) If, indeed, there is an immunologic basis for pre-eclampsia, it is more subtle than the methodology used in this study is capable of detecting.
(16) "These developments are clearly unwarranted on the basis of economic and budgetary fundamentals in these two member states and the steps that they are taking to reinforce those fundamentals."
(17) On the basis of mathematical models of the obtained dose-time-effect relationship, the risk of cancer occurrence due to small carcinogen doses is predicted.
(18) The relatively high incidence of nephroblastoma in the Nb rat using transplacentally administered ENU appears to represent a suitable basis for developing a rodent model of human nephroblastoma or Wilms' tumor.
(19) In this study we investigated the recovery or regenerative process of nasal mucosa in rabbits after mechanical injury on the basis of ultrastructural as well as functional observations.
(20) Three distinct antigenic regions of bovine somatotropin (bST) were identified on the basis of the ability of a set of monoclonal antibodies to bind to proteolytic fragments and deletion variants of recombinant bST (rbST) in Western blot analyses.
Substratum
Definition:
(n.) That which is laid or spread under; that which underlies something, as a layer of earth lying under another; specifically (Agric.), the subsoil.
(n.) The permanent subject of qualities or cause of phenomena; substance.
Example Sentences:
(1) The Very Late Antigens (VLAs) are alpha beta heterodimeric transmembrane proteins mediating cell-substratum as well as cell-cell interactions.
(2) Substratum wrinkling was indicative of tension development and quantitated as percent of cells contracted.
(3) The proliferative response did not require extra substratum or the presence of serum, even during cell isolation and plating.
(4) This behaviour therefore reflects the ability of the cells to modify the composition of the underlying substratum during growth.
(5) SMC also displayed several structurally detectable interactions with the fibrin substratum, such as organization of the gel by means of extension of numerous filamentous processes and contraction and wrinkling of the gel.
(6) Previous work from our laboratory had shown that goldfish retinal fragments explanted onto a polylysine substratum 1 to 2 weeks following optic nerve crush exhibit a striking clockwise pattern of neuritic outgrowth.
(7) Substratum-bound enzyme could be solubilized in buffers containing sodium dodecyl sulfate (SDS) or Triton X-100 and demonstrated by zymography following electrophoresis or assayed for amidolytic activity with a chromogenic substrate (Kabi S-2251).
(8) Type II cells cultured on this substratum showed a positive signal for mRNA for all three surfactant proteins; the abundance of these mRNAs, however, was significantly below that seen in freshly isolated type II cells.
(9) This increase may provide a firm substratum for reendothelialization after vascular injury.
(10) This research suggests that the substratum plays an important role in the maintenance or differentiation or both of mucous cells in culture.
(11) Time-lapse cinemicrography reveals that in clone B ZR-75-1 cells, which are not sensitive to the DNA synthesis-inhibitory effect of IL-6 or to its cell-separating effect on preformed colonies, IL-6 can still block rapid readherence of post-mitotic cells to their neighbors and to the substratum leading to enhanced dispersal of cancer cells into the culture medium.
(12) Confluent cultures of RPE from normal donors and from two donors with dominantly inherited RP were labeled with 3H-glucosamine and 35SO4 and the proteoglycans isolated from the medium, substratum and two cell membrane-associated compartments, designated "EDTA-released" and "cell-associated."
(13) We have investigated the molecular basis of the organization of cell-substratum contact in normal and neoplastic renal epithelium.
(14) When substratum adsorption sites were covered immediately after initial attachment, subsequent cell spreading was prevented.
(15) We now show that exposure of B16 melanoma cells to bromodeoxyuridine increases cell-substratum interactions concurrent with an increase in genome susceptibility to nucleases.
(16) The arrhythmias in competitive athletes may be classified as "benign," "paraphysiological" due to prolonged athletic training, or "pathological" due to hemodynamic effects on the athletic performance-risk-arrhythmogenic substratum.
(17) There is a fourfold increase in the number of organelles moving retrogradely in neurites that encounter a substratum-associated barrier to elongation; retrograde movements increase similarly in cultures exposed to cytochalasin at levels known to block growth cone advance.
(18) The changes in Ca2+ homeostasis and phosphoinositide hydrolysis induced by EGF were studied in human epidermoid carcinoma A431 cells both when attached to a substratum and after detachment and suspension.
(19) In the present study, however, when the basal lamina component laminin was used as a substratum, neurites grew out as uncurved spokes, were less fasciculated, and had an increased rate of elongation.
(20) One mechanism by which a cell might modulate its associations with the substratum is by selective, regulated proteolysis of an adhesion plaque component.