What's the difference between benzamide and pharmaceutical?
Benzamide
Definition:
(n.) A transparent crystalline substance, C6H5.CO.NH2, obtained by the action of ammonia upon chloride of benzoyl, as also by several other reactions with benzoyl compounds.
Example Sentences:
(1) The substituted benzamides tiapride and sulpiride, and the classic neuroleptic haloperidol, were studied in the rat to assess their interaction with the anterior pituitary (AP) dopamine (DA) receptors both in vitro ([3H]spiperone binding) and in vivo prolactin-PRL-release).
(2) Decreasing of the pH from 8.0 or 7.3 to 6.8 facilitated the dissociation of the substituted benzamide ligand [125I]epidepride from D2 receptors but inhibited dissociation of [3H]spiperone.
(3) BRL 34778, exo-4-amino-5-chloro-2-methoxy-N-[9-(4-fluorophenylmethyl)-9-azabi cyclo(3.3.1) non-3-yl]-benzamide, is a very potent and specific dopamine D2-receptor antagonist.
(4) Of the compounds tested, benzamide was the most potent inhibitor of poly(ADP-ribose) polymerase with an IC50 of 3.3 microM.
(5) Alizapride (ALZ) is a new benzamide derivative with promising antiemetic activity.
(6) In keeping with this conclusion, benzamidoethanol (a partial analogue of the covalent hydrate) and benzamide, N-methylbenzamide and N-ethylbenzamide (somewhat similar to the free aldehyde in size and hydrophobic character) are found to exhibit negligible affinity for the active site.
(7) The substituted benzamides, zacopride and BRL 24924 induced dose-dependent increases of the total EEG-energy of rats when applied intracerebroventricularly (i.c.v.)
(8) Twelve neuroleptics belonging to five chemical classes including phenothiazines, butyrophenones, benzamides, thioxanthenes and diphenylbutylpiperidines were injected i.p.
(9) The presence of cycloheximide or benzamide, during this pretreatment, inhibited this observed increase in resistance.
(10) The mechanisms of this effect and its consequences for the experimental use of benzamides are discussed.
(11) A randomized, double blind crossover trial compared the antiemetic effects of alizapride, a benzamide, and prochlorperazine, a phenothiazine, both administered intravenously to 32 patients treated with chemotherapy combinations containing cisplatin.
(12) While depletion of ATP by xanthine oxidase was prevented by 3-amino-benzamide, an inhibitor of DNA repair, inhibition of cAMP and progesterone production was still evident.
(13) We conclude that all four types of benzamides accommodated in the proposed receptor-interaction model are in low-energy conformations.
(14) Using high amide concentrations (4 mM) some doubtful results concerning the degradation of acetamide, benzamide, nicotinamide and pyrazinamide can be eliminated as could be demonstrated for different strains of mycobacteria.
(15) In vitro ADP-ribosylation of chromosomal proteins and its modulation by spermine, 3-aminobenzamide (3-AB) and benzamide were studied by incubating the nuclei of cerebral hemisphere of 3-, 14- and 30-day old rats with 32P-NAD+.
(16) [3H]spiperone and the [3H]benzamides), therefore, arise from an inherent property of the dopamine D2 receptor protein.
(17) The metabolism, disposition, and pharmacokinetics of 4-amino-N-(2,6-dimethylphenyl)benzamide (LY201116) have been studied in rats.
(18) A poly(ADP-ribose) polymerase inhibitor, benzamide (BA), was found to induce flat revertants of NIH 3T3 cells that had been transformed by human Ha-ras, rat Ki-ras, rat c-raf, and human ret-II.
(19) The antiemetic and locomotor effects of two substituted benzamides, zacopride and batanopride (BMY25801), were compared in ferrets after bilateral 60Co irradiation at 2, 4 or 6 Gy.
(20) The potency of benzamides (cisapride greater than BRL 24924 greater than zacopride greater than BRL 20627 greater than metoclopramide) is similar to their effect of 5-HT4 receptors positively coupled with an adenylate cyclase of fetal mouse colliculi neurons.
Pharmaceutical
Definition:
(a.) Of or pertaining to the knowledge or art of pharmacy, or to the art of preparing medicines according to the rules or formulas of pharmacy; as, pharmaceutical preparations.
Example Sentences:
(1) Senator Bernie Sanders of Vermont, who is also seeking the Democratic presidential nomination, recently proposed a bill that would ease the financial burden of prescription drugs on elderly Americans by allowing Medicare, the national social health insurance program, to negotiate with the pharmaceutical companies to keep prices down.
(2) Pharmaceutical services were provided from a large tent near the hospital, which consisted of an emergency treatment facility, two operating rooms, and a small medical-surgical ward.
(3) An investigation was done on the action in vitro of two pharmaceutical preparations containing Bi, De Nol and Pepto Bismol, on the fermentative capacity of intestinal bacteria.
(4) The conference was held from December 3 to 5, 1990 in the Washington, DC area and was sponsored by the American Association of Pharmaceutical Scientists, US Food and Drug Administration, Federation International Pharmaceutique, Health Protection Branch (Canada) and Association of Official Analytical Chemists.
(5) Silufol plates can be used for the control of the production of vitamins, their analysis in varying biological objects, as well as in biochemistry, medicine and pharmaceutics.
(6) Variations in bioavailability and intestinal absorption are important factors in the determination of dosage and should be reduced to a minimum by improved pharmaceutical formulations.
(7) This new derivative could represent a desirable complementation to rhbFGF for the development of more stable pharmaceutical formulations in wound healing applications.
(8) A report of the meeting will be published tomorrow in the Pharmaceutical Journal.
(9) There was no statistically significant difference between the figures obtained by the 2 methods, except for pharmaceutical expenditures (P = 0.005) which were grossly underevaluated by the program.
(10) Pharmaceutical services in a medical screening clinic are described.
(11) Slow release lithium was found a reliable pharmaceutical tool in both providing therapeutic results and avoiding severe side-effects.
(12) The efficacy and tolerability of a new pharmaceutical formulation of a non-steroid anti-inflammatory drug, nimesulide were studied in a double blind study in comparison with flurbiprofen and diclofenac sodium, in 150 patients suffering from postsurgical pain-inflammatory symptoms.
(13) A health committee meeting in Sacramento, the state capital, on Wednesday turned into a tense showdown between lawmakers seeking to argue that the science is unequivocally on the side of universal vaccination, and activists accusing them of being in the pocket of unscrupulous big pharmaceutical companies.
(14) Clarithromycin (TE-031, A-56268) is a new 14-membered ring macrolide antibiotic developed by Taisho Pharmaceutical Co., Ltd. TE-031 has a methoxy group at position 6 in its structure.
(15) This is especially relevant in light of the use of laboratory mammals to predict the metabolism of novel pharmaceutical agents in humans.
(16) The Double Irish loophole allows US companies, mostly in the technology and pharmaceutical sectors, to reduce their effective tax bill far below Ireland’s already generous 12.5% corporate tax rate by shifting most of their taxable income from an operating company in Ireland to another Irish-registered firm located in an offshore tax haven, such as Bermuda.
(17) Propylene glycol (PG) is widely used as a drug solvent in the pharmaceutical industry.
(18) The experimental drug, known as GSK2606414, is made by pharmaceutical company GlaxoSmithKline.
(19) The Office for National Statistics reported a drop in output across the manufacturing sector, from pharmaceutical firm to makers of computers, electronic & optical products; and food products, beverages & tobacco goods.
(20) The second approach for a UK-listed drug company by a US rival underlined the deal-making zeal that has seized the pharmaceutical sector.