(n.) A volatile, very inflammable liquid, C6H6, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation. The name is sometimes applied also to the impure commercial product or benzole, and also, but rarely, to a similar mixed product of petroleum.
Example Sentences:
(1) The low affinity of several N1-alkylpyrroleethylamines suggests that the benzene portion of the alpha-methyltryptamines is necessary for significant affinity.
(2) Essential parameters of hepatic functioning in 84 labourers, whose exposition to benzene is differing in assimilation as well as length of time is discussed.--45 persons from the same county without contact to benzene or hepatotoxic agents served as control-group.
(3) In the liver, the major site of benzene metabolism, benzene is converted by a cytochrome P-450-mediated pathway to phenol, the major metabolite, and the secondary metabolites, hydroquinone and catechol.
(4) The significance of the present findings on the mutual suppression of metabolism between benzene and toluene is discussed in relation to solvent toxicology and biological monitoring of exposure to the solvents.
(5) Service station attendants' exposure to benzene, based on 85 TWA results at 7 stations, were well below 1 ppm except one exposure of 2.08 ppm.
(6) For cases where background contamination could not be adequately controlled, the assay was modified for the quantitative determination of labelled benzenes six mass units heavier than natural benzene (benzene-d6 or benzene-13C6).
(7) We have investigated the whole-body dermal penetration of styrene, xylene, toluene, perchloroethylene, benzene, halothane, hexane, and isoflurane in rats and compared the permeability constants with available human studies on vapor penetration.
(8) Numerical and structural chromosome changes in bone marrow cells have been described in subjects with benzene haemopathy.
(9) On the other hand, Sudan III pretreatment suppressed benzene-induced CA at all periods after the benzene injection.
(10) Benzene is the only chemical agent for which strong evidence of leukaemogenesis exists.
(11) 14C-Methylthio-labelled 2-methylthio-4-ethylamino-6-tert-butylamino-sym-triazine (terbutryn), pentachlorothioanisole (PCTA), and 1,4-bis(methylthio)tetrachloro-benzene (bis-MTTCB) and their methylthio-oxidation congeners were reacted with glutathione (GSH) in the presence and absence of immobilized liver microsomal enzymes.
(12) The drug is extracted from buffered plasma at pH 9.0 with benzen.
(13) Laser photolysis techniques have been used to characterize the reactivity of triplet state lipoidal benzophenone derivatives toward fatty acids and glycerides in benzene solution.
(14) In experiments in vitro, neither benzene, toluene nor xylene changed the number of sister-chromatid exchanges (SCEs) or the number of chromosomal aberrations in human lymphocytes.
(15) The compound is extracted from aqueous solution with benzene and cleaned up by liquid chromatography.
(16) In pursuing the study on pyridodiazepinone derivatives, in order to verify the variation of biological activity induced by replacement of the heteroaromatic with an aromatic nucleus and by the introduction of chlorine on the benzene ring, a series of 1-[(dialkylamino)alkyl]-4-phenyl-1,3-dihydro-2H-1,4-benzodiazepin- 2-ones and of 7-chloro-analogues were prepared.
(17) Benzene toluene, styrene, 1,1,1-trichloroethylene, and tetrachloroethylene are taken as examples of solvents showing various toxicokinetic properties.
(18) DAS protected the anion exchange system not only against inhibition by DNFB but also by m-isothiocyanato benzene sulfonic acid.
(19) The m-xylene-adapted microorganisms in the aquifer column degraded toluene, benzaldehyde, benzoate, m-toluylaldehyde, m-toluate, m-cresol, p-cresol, and p-hydroxybenzoate but were unable to metabolize benzene, naphthalene, methylcyclohexane, and 1,3-dimethylcyclohexane.
(20) Anticonvulsant activity and toxicity of 20 arylsuccinimides were quantitatively correlated with the hydrophobic, electronic and steric parameters of the substituents in the benzene ring and at the nitrogen atom.
Benzol
Definition:
(n.) An impure benzene, used in the arts as a solvent, and for various other purposes. See Benzene.
Example Sentences:
(1) of methotrexate (MTX) methasquin (MQ), aminopterin, and N-([2,4-diamino-5-chloro-6-quinazolinyl) methyl]-amino)benzol)-L-glutamate (5-Cl-deaza-AM), total accumulation in small intestine was vie- to eight-fold greater than the dihydrofolate reductase content.
(2) In persons exposed to the actions of both cigarette smoking and benzol and its homologues, more significant decreases of IgA, AgG, IgM and lysozyme concentrations were revealed as compared to those affected by one of the factors.
(3) The mother had received several injections of benzol during pregnancy with an intent of inducing abortion.
(4) A preliminary introduction to rats of acetylene amines--1,4 bis (3-morpholinopropynyl) benzol 3,4,5-(morpholinopropynyl)-1-methylpyrazol and also of tocopherol antioxidant and gutumine antihypoxant averts activation of the lipids peroxidation processes.
(5) That the resulting "chemically aminoacylated" tRNA's were identical with those prepared by enzymatic aminoacylation was judged by comparison of 1) chromatographic properties on benzolated diethylaminoethyl-cellulose, 2) rates of chemical deacylation, and 3) affinities for elongation factor Tu, as well as 4) the ability of misacylated tRNA's so derived to be deacylated chemically and then reactivated enzymatically with their cognate amino acids.
(6) In the presence of added NADPH, binding of benzol[a]pyrene to DNA by nuclei increased rapidly for at least 20 min.
(7) The latter included indene, benzimidazole, benzofuran, benzol[beta]thiophene, and several other related nitrogen-containing heterocycles.
(8) Examination is performed on 60 workers at the age 30 to 55 years old, in contact with organic solvents: benzine, toluene, benzol, acetone, etc., which are above the maximum admissible concentrations (MAC).
(9) The activity of GABA transamination enzyme in the brain motor cortex under the benzole effect is not changed in newborns and three-month rats, in 10- and 21-days rats it decreases, in 12- and 24-months animals it increases.
(10) 5-Azacytidine (AZC) was studied in a lung cancer model in outbred and syngeneic (F1D) hamsters wherein benzol[a]pyrene (BP) from sustained release implants (SRI) induces preneoplastic mucosal changes which progress to bronchogenic cancer.
(11) The content of GABA increases in all the areas during ontogeny with benzole intoxication.
(12) In benzol hypoplasia of hemopoiesis there was a decrease in the number of the CFU in the hemopoietic organs without any changes in the distribution of their cell types.
(13) Rubidazone, the new semi-synthetic benzol hydrazone hydrochloride derivative of dauorubicin, has proved on a molecular weight basis to be less toxic than adriamycin and similar to daunorubicin in cardiac toxicity studies in the hamster as well as in other in vivo and in vitro test systems.
(14) A study was made of the effect of benzol on the colony-forming activity in the spleen and the bone marrow of mice in 4 different experimental variants.
(15) The question was to be answered if beta-amino-isobutyl-benzol worsens the GTT and if the lipolytic effect outranges lipolysis during fasting.
(16) The possibility of a causal relationship between the administration of benzol and the occurrence of the defect is supported by the existence of previously reported cases of cerebral malformations following maternal exposure to organic solvents.
(17) Administration of benzol to the lethally irradiated mice after the transplantation of normal bone marrow suspension led to a sharp decrease in the number of CFU with a preponderant depression of the granulocytic colony formation.
(18) A GLC method has been developed to measure chlorophenoxyisobutyric acid in plasma after benzol extraction and transformation to its methyl ester, using methyl laurate as the internal standard.
(19) In mouse hepatoma Hepa-1c1c7 cultures, polycyclic aromatic compounds such as benzol[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) activate the Cyp1a-1 (cytochrome P(1)450) and Nmo-1[NAD(P)H:menadione-oxidoreductase] genes, two members of the aromatic hydrocarbon (Ah)-responsive gene battery.
(20) These data afford to suppose the change in the properties of microenvironment of the hemopoietic stem cells in experimental benzol poisoning.