What's the difference between benzile and benzole?
Benzile
Definition:
(n.) A yellowish crystalline substance, C6H5.CO.CO.C6H5, formed from benzoin by the action of oxidizing agents, and consisting of a doubled benzoyl radical.
Example Sentences:
(1) We have characterized the binding of the selective muscarinic antagonist [3H]pirenzepine ([3H])PZ) and the classical muscarinic antagonist (-)-[3H]quinuclidinyl benzilate ((-)-[3H]QNB) to muscarinic cholinergic sites in rabbit peripheral lung membranes.
(2) To analyze muscarinic receptors on rat pancreatic acini, we studied the binding of 125I-quinuclidinyl benzilate (125I-QNB) and N-[3H]-methylscopolamine ([3H]-NMS) to these acini.
(3) A comparison was made of the behavioral effects in cats of the dextro and levo isomers of 3-quinuclidinyl benzilate (QB), using a special computer-controlled program.
(4) The specific binding of [3H]quinuclidinyl benzilate (QNB) to cholinergic receptors in sections of penile crura of the rat was analyzed by in vitro neurotransmitter autoradiography.
(5) These compounds, however, also inhibited the binding of [3H]quinuclidinyl benzilate to cortical membranes.
(6) Although 5'-guanylylimidodiphosphate was able to reduce the affinity of carbachol for membrane bound mAChR and to increase slightly the binding of (-)-[3H]quinuclidinyl benzilate it had no effect on ligand binding to the solubilized mAChR.
(7) The number of M-cholinergic receptors on spleen B-lymphocytes of CBA mice was determined using radioactive blocker 3H-Quinuclidinil benzilate.
(8) We found that muscarinic cholinergic synaptic receptor density determined with [3H] quinuclidinly benzilate was decreased by 40% in homogenates of the tempeoral cortex of 26 alcohol abusers compared with 26 matched nonalcoholic controls.
(9) Subtypes of muscarinic receptors were characterized in the frontal cortices of control and Alzheimer brains, with labelled quinuclidinyl benzilate [3H]QNB and the unlabelled muscarinic antagonists pirenzepine, AF-DX 116, hexahydro-sila-diphenidol (HHSiD), para-fluoro-hexahydro-sila-diphenidol (p-F-HHSiD) and himbacine.
(10) The binding of quinuclidinyl [3H]benzilate and the inhibition of quinuclidinyl benzilate (QNB) binding by agonists and antagonists were examined at temperatures between 2 degrees C and 27 degrees C. The density of specific binding sites and the relative proportions of high- and low-affinity binding components of drugs were unaffected by the temperature changes.
(11) Specific binding of tritiated quinuclidinyl benzilate (3H-QNB) to surface membrane muscarinic receptors was utilized to identify plasma membrane (PM) fractions from smooth muscle of the rabbit urinary bladder.
(12) In vitro binding studies with the muscarinic ligand, 1-quinuclidinyl [phenyl-4 (n) -3H] benzilate) were performed on homogenates of fetal (n = 3) and adult (n = 3) pituitaries.
(13) The equilibrium binding of the antagonist [3H]-4-N-methylpiperidyl benzilate ([3H]4NMPB) to detergent-solubilized receptors resembled binding to neural membranes and exhibited subnanomolar affinity, saturability, and simple mass action kinetics.
(14) Pretreatment with oxotremorine also reduced the density of muscarinic receptors without affecting the affinity of these sites for [3H]quinuclidinyl benzilate.
(15) Bilateral injection of propylbenzilylcholine mustard (PrBCM) into both the frontal and parietal cortex at doses of 2.25 X 4 to 22.5 X 4 micrograms decreased mACh receptors dose-dependently, as assessed by [3H]quinuclidinyl benzilate binding studies.
(16) Human retinal pigment epithelial (RPE) cells in culture demonstrated saturable specific binding of [3H]quinuclidinyl benzilate (QNB).
(17) Pirenzepine displacement (inhibition constant = 0.5 X 10(-6) M) classifies tritiated I-quinuclidinyl benzilate binding sites as M2-muscarinic receptors.
(18) We made studies about the changes of muscarinic cholinergic receptors in experimental hydrocephalic rat brains using binding assay, macroautoradiography, and microautoradiography with 3H-quinuclidinyl benzilate (QNB), which has a high and specific affinity for muscarinic receptors.
(19) Apparent affinities of the reconstituted mAChR and G proteins for carbachol and GDP, respectively, were estimated from the effects of these ligands on the binding of [3H]-L-quinuclidinyl benzilate ([3H]QNB) to mAChR and [35S]guanosine 5'-O-(3-thiotriphosphate) ([35S]GTP gamma S) to G proteins in the presence of different concentrations of MgCl2.
(20) Two and five days after FAS injections into the amygdala, the density of muscarinic receptor decreased about 50% as measured by the specific bindings of 3H-quinuclidinyl benzilate and 3H-oxotremorine.
Benzole
Definition:
(n.) Alt. of Benzol
Example Sentences:
(1) of methotrexate (MTX) methasquin (MQ), aminopterin, and N-([2,4-diamino-5-chloro-6-quinazolinyl) methyl]-amino)benzol)-L-glutamate (5-Cl-deaza-AM), total accumulation in small intestine was vie- to eight-fold greater than the dihydrofolate reductase content.
(2) In persons exposed to the actions of both cigarette smoking and benzol and its homologues, more significant decreases of IgA, AgG, IgM and lysozyme concentrations were revealed as compared to those affected by one of the factors.
(3) The mother had received several injections of benzol during pregnancy with an intent of inducing abortion.
(4) A preliminary introduction to rats of acetylene amines--1,4 bis (3-morpholinopropynyl) benzol 3,4,5-(morpholinopropynyl)-1-methylpyrazol and also of tocopherol antioxidant and gutumine antihypoxant averts activation of the lipids peroxidation processes.
(5) That the resulting "chemically aminoacylated" tRNA's were identical with those prepared by enzymatic aminoacylation was judged by comparison of 1) chromatographic properties on benzolated diethylaminoethyl-cellulose, 2) rates of chemical deacylation, and 3) affinities for elongation factor Tu, as well as 4) the ability of misacylated tRNA's so derived to be deacylated chemically and then reactivated enzymatically with their cognate amino acids.
(6) In the presence of added NADPH, binding of benzol[a]pyrene to DNA by nuclei increased rapidly for at least 20 min.
(7) The latter included indene, benzimidazole, benzofuran, benzol[beta]thiophene, and several other related nitrogen-containing heterocycles.
(8) Examination is performed on 60 workers at the age 30 to 55 years old, in contact with organic solvents: benzine, toluene, benzol, acetone, etc., which are above the maximum admissible concentrations (MAC).
(9) The activity of GABA transamination enzyme in the brain motor cortex under the benzole effect is not changed in newborns and three-month rats, in 10- and 21-days rats it decreases, in 12- and 24-months animals it increases.
(10) 5-Azacytidine (AZC) was studied in a lung cancer model in outbred and syngeneic (F1D) hamsters wherein benzol[a]pyrene (BP) from sustained release implants (SRI) induces preneoplastic mucosal changes which progress to bronchogenic cancer.
(11) The content of GABA increases in all the areas during ontogeny with benzole intoxication.
(12) In benzol hypoplasia of hemopoiesis there was a decrease in the number of the CFU in the hemopoietic organs without any changes in the distribution of their cell types.
(13) Rubidazone, the new semi-synthetic benzol hydrazone hydrochloride derivative of dauorubicin, has proved on a molecular weight basis to be less toxic than adriamycin and similar to daunorubicin in cardiac toxicity studies in the hamster as well as in other in vivo and in vitro test systems.
(14) A study was made of the effect of benzol on the colony-forming activity in the spleen and the bone marrow of mice in 4 different experimental variants.
(15) The question was to be answered if beta-amino-isobutyl-benzol worsens the GTT and if the lipolytic effect outranges lipolysis during fasting.
(16) The possibility of a causal relationship between the administration of benzol and the occurrence of the defect is supported by the existence of previously reported cases of cerebral malformations following maternal exposure to organic solvents.
(17) Administration of benzol to the lethally irradiated mice after the transplantation of normal bone marrow suspension led to a sharp decrease in the number of CFU with a preponderant depression of the granulocytic colony formation.
(18) A GLC method has been developed to measure chlorophenoxyisobutyric acid in plasma after benzol extraction and transformation to its methyl ester, using methyl laurate as the internal standard.
(19) In mouse hepatoma Hepa-1c1c7 cultures, polycyclic aromatic compounds such as benzol[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) activate the Cyp1a-1 (cytochrome P(1)450) and Nmo-1[NAD(P)H:menadione-oxidoreductase] genes, two members of the aromatic hydrocarbon (Ah)-responsive gene battery.
(20) These data afford to suppose the change in the properties of microenvironment of the hemopoietic stem cells in experimental benzol poisoning.