(1) of methotrexate (MTX) methasquin (MQ), aminopterin, and N-([2,4-diamino-5-chloro-6-quinazolinyl) methyl]-amino)benzol)-L-glutamate (5-Cl-deaza-AM), total accumulation in small intestine was vie- to eight-fold greater than the dihydrofolate reductase content.
(2) In persons exposed to the actions of both cigarette smoking and benzol and its homologues, more significant decreases of IgA, AgG, IgM and lysozyme concentrations were revealed as compared to those affected by one of the factors.
(3) The mother had received several injections of benzol during pregnancy with an intent of inducing abortion.
(4) A preliminary introduction to rats of acetylene amines--1,4 bis (3-morpholinopropynyl) benzol 3,4,5-(morpholinopropynyl)-1-methylpyrazol and also of tocopherol antioxidant and gutumine antihypoxant averts activation of the lipids peroxidation processes.
(5) That the resulting "chemically aminoacylated" tRNA's were identical with those prepared by enzymatic aminoacylation was judged by comparison of 1) chromatographic properties on benzolated diethylaminoethyl-cellulose, 2) rates of chemical deacylation, and 3) affinities for elongation factor Tu, as well as 4) the ability of misacylated tRNA's so derived to be deacylated chemically and then reactivated enzymatically with their cognate amino acids.
(6) In the presence of added NADPH, binding of benzol[a]pyrene to DNA by nuclei increased rapidly for at least 20 min.
(7) The latter included indene, benzimidazole, benzofuran, benzol[beta]thiophene, and several other related nitrogen-containing heterocycles.
(8) Examination is performed on 60 workers at the age 30 to 55 years old, in contact with organic solvents: benzine, toluene, benzol, acetone, etc., which are above the maximum admissible concentrations (MAC).
(9) The activity of GABA transamination enzyme in the brain motor cortex under the benzole effect is not changed in newborns and three-month rats, in 10- and 21-days rats it decreases, in 12- and 24-months animals it increases.
(10) 5-Azacytidine (AZC) was studied in a lung cancer model in outbred and syngeneic (F1D) hamsters wherein benzol[a]pyrene (BP) from sustained release implants (SRI) induces preneoplastic mucosal changes which progress to bronchogenic cancer.
(11) The content of GABA increases in all the areas during ontogeny with benzole intoxication.
(12) In benzol hypoplasia of hemopoiesis there was a decrease in the number of the CFU in the hemopoietic organs without any changes in the distribution of their cell types.
(13) Rubidazone, the new semi-synthetic benzol hydrazone hydrochloride derivative of dauorubicin, has proved on a molecular weight basis to be less toxic than adriamycin and similar to daunorubicin in cardiac toxicity studies in the hamster as well as in other in vivo and in vitro test systems.
(14) A study was made of the effect of benzol on the colony-forming activity in the spleen and the bone marrow of mice in 4 different experimental variants.
(15) The question was to be answered if beta-amino-isobutyl-benzol worsens the GTT and if the lipolytic effect outranges lipolysis during fasting.
(16) The possibility of a causal relationship between the administration of benzol and the occurrence of the defect is supported by the existence of previously reported cases of cerebral malformations following maternal exposure to organic solvents.
(17) Administration of benzol to the lethally irradiated mice after the transplantation of normal bone marrow suspension led to a sharp decrease in the number of CFU with a preponderant depression of the granulocytic colony formation.
(18) A GLC method has been developed to measure chlorophenoxyisobutyric acid in plasma after benzol extraction and transformation to its methyl ester, using methyl laurate as the internal standard.
(19) In mouse hepatoma Hepa-1c1c7 cultures, polycyclic aromatic compounds such as benzol[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin) activate the Cyp1a-1 (cytochrome P(1)450) and Nmo-1[NAD(P)H:menadione-oxidoreductase] genes, two members of the aromatic hydrocarbon (Ah)-responsive gene battery.
(20) These data afford to suppose the change in the properties of microenvironment of the hemopoietic stem cells in experimental benzol poisoning.