(1) A novel bicyclic prostaglandin analogue, (1S)-[1 alpha,2 alpha(Z),3 alpha,4 alpha]-7-[3-[(hexylthio)methyl]-7- oxabicyclo [2.2.1]hept-2-yl]-5-heptenoic acid ((-)-10), and its cogeners were found to be potent antagonists at the TxA2 receptor.
(2) The authors report an ocular luxation of a four-year-old girl after a bicycle accident.
(3) In a Bloomberg article last week, for example, one Stanford student compared women who get raped to unlocked bicycles : ‘Do I deserve to have my bike stolen if I leave it unlocked on the quad?’ [Chris] Herries, 22, said.
(4) Considerate touches includes the free use of cruiser bicycles (the best method of tackling the Palm Springs main drag), home-baked cookies … and if you'd like to get married, ask the manager: he's a minister.
(5) Subjects underwent measurement of lung volumes, arterial blood gas analysis and an incremental bicycle exercise test.
(6) Each patient underwent graded bicycle exercise testing to define maximal performance, and prolonged exercise at 70% of their peak work capacity.
(7) The data of bicycle ergometry test and echocardiography were studied and compared in patients with postinfarction cardiosclerosis and type II diabetes mellitus without the clinical signs of heart failure.
(8) We had our bicycles and we were just turned loose all day.
(9) Near maximal supine exercise for 10 min on a bicycle ergometer caused a small increase in plasma renin activity during exertion with a much larger increase during recovery which reached a peak between 10-20 min.
(10) In all patients a standardized bicycle-ergometric exercise sitting and a coronarography as well as a ventriculography were performed.
(11) He has just performed a skit now about his bicycle scheme, which included a swipe at the French (because their scheme resulted in many more cycles being pinched, apparently.)
(12) Seven healthy volunteers were exposed to head-down tilt at -15 degrees for 5 h. Before and after exposure they exercised on a bicycle ergometer in the supine and seated positions.
(13) The pressure waves recorded in the container were added by computer to those recorded intra-arterially during bicycle ergometry.
(14) An incremental, symptom-limited, bicycle exercise test was done one month after the myocardial infarction, and blood samples were taken for determination of plasma potassium.
(15) A bicyclic hexadecapeptide, which corresponds to the sequence 36-51 and contains the chymotrypsin-reactive Leu-43-Ser-44 bond of soybean Bowman-Birk inhibitor, has been synthesized.
(16) Ester already has a second child with her husband, who makes a living using his bicycle to provide a taxi service.
(17) The new protocol (standardised exponential exercise protocol, STEEP) is suitable for use on either a treadmill or a bicycle ergometer.
(18) The most frequent cause of abdominal injury in children was a bicycle accident.
(19) To test this premise, 14 healthy, untrained men trained four days per week for 20 weeks on a bicycle ergometer for endurance (END Group, n = 4), on an isokinetic device for increased torque production (ITP Group, n = 5), or on both devices (COMBO Group, n = 5).
(20) The KB was found to be remarkably tolerant of changes in the electronic constitution and lipophilicity of the bicyclic ring system (template).
Coumarin
Definition:
(n.) The concrete essence of the tonka bean, the fruit of Dipterix (formerly Coumarouna) odorata and consisting essentially of coumarin proper, which is a white crystalline substance, C9H6O2, of vanilla-like odor, regarded as an anhydride of coumaric acid, and used in flavoring. Coumarin in also made artificially.
Example Sentences:
(1) A phytochemical investigation of an ethanolic extract of the whole plant of Echites hirsuta (Apocynaceae) resulted in the isolation and identification of the flavonoids naringenin, aromadendrin (dihydrokaempferol), and kaempferol; the coumarin fraxetin; the triterpene ursolic acid; and the sterol glycoside sitosteryl glucoside.
(2) Among them, the coumarins, rutins, Centella asiatica extracts, procyanoside oligomers are the most prescribed.
(3) This novel coumarin derivative significantly inhibited skin tumor initiation by DMBA in SENCAR mice when given at a dose of 200 nmol, 5 min (69% inhibition) or 24 h (76% inhibition) prior to initiation.
(4) The aflatoxins are a family of complex coumarins produced by species of Aspergillus that are toxic and carcinogenic in animals.
(5) Coumarin and 7-HCG are best fitted to an open two-compartment model, whereas 7-HC is best fitted to an open one-compartment model.
(6) Drug interactions with coumarin anticoagulants and sulphonylurea compounds may produce bleeding episodes and hypoglycaemia, respectively.
(7) Neither macroscopic nor microscopic examination of liver tissue revealed any pathological alterations caused by coumarin.
(8) 10 coumarins used in perfumery, cosmetics and ointments, have been investigated by 2 different methods to determine their sensitizing capacity.
(9) Coumarin-induced hepatotoxicity was associated with significant increases in relative liver weight, plasma alanine and aspartate aminotransferase activities and hepatic non-protein sulphydryl groups.
(10) Treatment of isolated canine renal Na,K-ATPase with a stable diazomethane analog, 4-(diazomethyl)-7-(diethylamino)-coumarin (DEAC), results in enzyme inactivation.
(11) Among the non-infectious agents alcohol is the most important, followed by a combination of anticonvulsant drugs, valproic acid, retinoic acid, lithium, coumarin derivates, methyl mercury, aminopterin and methotrexate, cocaine and amniogenic bands.
(12) The results demonstrate a reserve capacity for the coumarin-sensitive reductase; at least 70% of the hepatic vitamin K1 2,3-epoxide reductase activity has to be eliminated before the vitamin K-dependent carboxylation of the clotting factors objectively becomes compromised.
(13) Coumarin and cimetidine appear to be safe and active agents in the treatment of metastatic renal carcinoma.
(14) This correlated well with the suppression by coumarin of the dextran-induced leucocyte response in vivo.
(15) In three patients painful reddening of a well-circumscribed area of the skin occurred within five days of starting anticoagulant treatment with phenprocoumon (Marcumar), and within a short time it developed into a full-blown picture of coumarin necrosis.
(16) A 2-7-fold increase in response to the inducers was seen in the amount of P-450Coh (cytochrome P-450 isoenzyme catalysing coumarin 7-hydroxylation) protein in Western immunoblots.
(17) These findings suggest that the coumarin ring system is largely responsible for the pharmacodynamic properties of warfarin, whereas the side-chain dictates the disposition and metabolism of the drug.
(18) The latter effect was effectively suppressed by a concomitant administration of a combination of troxerutin and coumarin (Venalot).
(19) A substantial improvement in the rate of detection of organic lesions affecting the olfactory pathway can be achieved by substituting odours such as musk ketone, exaltolide, linalyl acetate and coumarin for those in current use.
(20) Coumarin concentrations that inhibited growth of Pythium sp.