(1) A novel bicyclic prostaglandin analogue, (1S)-[1 alpha,2 alpha(Z),3 alpha,4 alpha]-7-[3-[(hexylthio)methyl]-7- oxabicyclo [2.2.1]hept-2-yl]-5-heptenoic acid ((-)-10), and its cogeners were found to be potent antagonists at the TxA2 receptor.
(2) The authors report an ocular luxation of a four-year-old girl after a bicycle accident.
(3) In a Bloomberg article last week, for example, one Stanford student compared women who get raped to unlocked bicycles : ‘Do I deserve to have my bike stolen if I leave it unlocked on the quad?’ [Chris] Herries, 22, said.
(4) Considerate touches includes the free use of cruiser bicycles (the best method of tackling the Palm Springs main drag), home-baked cookies … and if you'd like to get married, ask the manager: he's a minister.
(5) Subjects underwent measurement of lung volumes, arterial blood gas analysis and an incremental bicycle exercise test.
(6) Each patient underwent graded bicycle exercise testing to define maximal performance, and prolonged exercise at 70% of their peak work capacity.
(7) The data of bicycle ergometry test and echocardiography were studied and compared in patients with postinfarction cardiosclerosis and type II diabetes mellitus without the clinical signs of heart failure.
(8) We had our bicycles and we were just turned loose all day.
(9) Near maximal supine exercise for 10 min on a bicycle ergometer caused a small increase in plasma renin activity during exertion with a much larger increase during recovery which reached a peak between 10-20 min.
(10) In all patients a standardized bicycle-ergometric exercise sitting and a coronarography as well as a ventriculography were performed.
(11) He has just performed a skit now about his bicycle scheme, which included a swipe at the French (because their scheme resulted in many more cycles being pinched, apparently.)
(12) Seven healthy volunteers were exposed to head-down tilt at -15 degrees for 5 h. Before and after exposure they exercised on a bicycle ergometer in the supine and seated positions.
(13) The pressure waves recorded in the container were added by computer to those recorded intra-arterially during bicycle ergometry.
(14) An incremental, symptom-limited, bicycle exercise test was done one month after the myocardial infarction, and blood samples were taken for determination of plasma potassium.
(15) A bicyclic hexadecapeptide, which corresponds to the sequence 36-51 and contains the chymotrypsin-reactive Leu-43-Ser-44 bond of soybean Bowman-Birk inhibitor, has been synthesized.
(16) Ester already has a second child with her husband, who makes a living using his bicycle to provide a taxi service.
(17) The new protocol (standardised exponential exercise protocol, STEEP) is suitable for use on either a treadmill or a bicycle ergometer.
(18) The most frequent cause of abdominal injury in children was a bicycle accident.
(19) To test this premise, 14 healthy, untrained men trained four days per week for 20 weeks on a bicycle ergometer for endurance (END Group, n = 4), on an isokinetic device for increased torque production (ITP Group, n = 5), or on both devices (COMBO Group, n = 5).
(20) The KB was found to be remarkably tolerant of changes in the electronic constitution and lipophilicity of the bicyclic ring system (template).
Quinoxaline
Definition:
(n.) Any one of a series of complex nitrogenous bases obtained by the union of certain aniline derivatives with glyoxal or with certain ketones.
Example Sentences:
(1) AOAA-induced (0.25 mumol-1 mumol) striatal lesions in adult rats displayed excitotoxic characteristics and could be prevented by the N-methyl-D-aspartate (NMDA) receptor antagonists (-)-2-amino-7-phosphono-heptanoate (AP7; 0.25 mumol) or kynurenate (KYNA; 0.5 mumol), but not by the non-NMDA antagonist 2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline (NBQX; 0.25 mumol).
(2) Oxythioquinox, Plictran (tricyclohexylhydroxytin), Nissol [2-fluoro-N-methyl-N-(1-naphthyl)acetamide], and chlordimeform are examples of quinoxaline, organotin, organofluorine, and formamidine acaricides, respectively.
(3) Addition of the non-N-methyl-D-aspartate (non-NMDA) selective antagonist 6-cyano-7-nitro-quinoxaline-2,3-dione (CNQX) to the slice surface near the recording electrode resulted in a rapid (within 30-45 s) suppression of the EPSP.
(4) A significant stimulation in liver microsomal enzymes occurred after 2,3-dimethyl quinoxaline and 2,3-diphenyl quinoxaline treatments; these changes were associated with increases in cytochrome P-450 level and in RNA and protein contents of the microsomal fraction.
(5) Synthetic heterocyclic quinones (107 samples) consisting of o- and p-quinoline quinones, o-isoquinoline quinones and p-quinoxaline quinones as well as o- and p-naphthoquinones (3 samples) were tested for their inhibitory activities against avian myeloblastosis virus reverse transcriptase (AMV-RT) and cytotoxic activities against mouse lymphoblastoma L5178Y cells.
(6) Quinoxalines and kynurenates antagonized in a non-competitive manner L-glutamate-induced contraction.
(7) The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepripriate (AMPA)-receptor blocker, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F) quinoxaline (NBQX), administered as an intravenous dose of 29.76 and 89.29 mumol kg-1 (10 & 30 mg kg-1), which is sufficient to block seizures and protect against ischaemic brain damage, did not inhibit spreading depression.
(8) Second, the sialic acids content is measured fluorometrically using their precolumn conversion to quinoxaline derivatives.
(9) 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) is a potent bacterial promutagen and carcinogen, formed when beef is cooked.
(10) These cell wall skeletons also bound 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1), 2-amino-5-phenylpyridine (Phe-P-1), IQ, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQX).
(11) Their ability to suppress the antilipolytic effect of an alpha-2 agonist [UK-14,304 (5-bromo-6-(2-imidazolin-2-ylamino)-quinoxaline)] on isolated fat cells was equivalent.
(13) The tumorigenic activities of four representative heterocyclic amine food pyrolysates, 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,8-dimethylimidazo[4,5f]quinoxaline (MeIQx), and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), were assessed in the neonatal male B6C3F1 mouse and were compared with that of the potent human carcinogen, 4-amino-biphenyl (4-ABP).
(14) The chemotherapeutic effect of di-N-quinoxaline oxide derivatives--quinoxidine and diaxidine, as contrasted to that of carbenicillin and hentamycin with their 3- and 10-day application, was studied on a model of a burn in mice infected with Pseudomonas eruginosa.
(15) Postsynaptic responses in NL were blocked completely, in a concentration-dependent and reversible fashion, by bath application of the broad-spectrum excitatory amino acid (EAA) antagonist kynurenic acid, the 'non-NMDA' EAA receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX), and the EAA agonists domoic acid, kainic acid, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), and quisqualic acid.
(16) Individual 2-carboxylic acids derived from imidazo[1,2-a]quinolines, imidazo[1,2-a]quinoxalines, imidazo[1,2-a]quinoxalinones, pyrrolo[1,2-a]quinoxalinones, pyrrolo[2,3-a]quinoxalinones, and imidazo[2,1-b]benzothiazoles showed iv activities up to 10(3) times as potent as DSCG and many of them showed significant oral activity.
(17) An excellent correlation was observed between inhibitory potencies of the quinoxaline derivatives against kainate and AMPA currents, in support of the contention that in this preparation these two agonists act at a single site.
(18) Two members of the quinoxaline antibiotic family, echinomycin and triostin A, form crystals complexed to a DNA fragment with the sequence d(CpGpTpApCpG).
(19) The activities of 1,2-dimethylhydrazine, dimethylnitrosamine, and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in the Dlb-1 assay more accurately reflect their carcinogenic potential than do many in vitro bioassays.
(20) The activation of three other food mutagens, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and aflatoxin B1 (AFB1) was also inhibited by these fatty acids.