(n.) The act or process of one who, or that which, binds.
(n.) Anything that binds; a bandage; the cover of a book, or the cover with the sewing, etc.; something that secures the edge of cloth from raveling.
(pl.) The transoms, knees, beams, keelson, and other chief timbers used for connecting and strengthening the parts of a vessel.
Example Sentences:
(1) Tryptic digestion of the membranes caused complete disappearance of the binding activity, but heat-treatment for 5 min at 70 degrees C caused only 40% loss of activity.
(2) Comparison of the S100 alpha-binding protein profiles in fast- and slow-twitch fibers of various species revealed few, if any, species- or fiber type-specific S100 binding proteins.
(3) Competition with the labelled 10B12 MAb for binding to the purified antigen was demonstrated in sera of tumor-bearing and immune rats.
(4) These studies led to the following conclusions: (a) all the prominent NHP which remain bound to DNA are also present in somewhat similar proportions in the saline-EDTA, Tris, and 0.35 M NaCl washes of nuclei; (b) a protein comigrating with actin is prominent in the first saline-EDTA wash of nuclei, but present as only a minor band in the subsequent washes and on washed chromatin; (c) the presence of nuclear matrix proteins in all the nuclear washes and cytosol indicates that these proteins are distributed throughout the cell; (d) a histone-binding protein (J2) analogous to the HMG1 protein of K. V. Shooter, G.H.
(5) Power urges the security council to "take the kind of credible, binding action warranted."
(6) The binding properties of formalin-fixed amelanotic melanoma cells were not identical to those of endothelial or unfixed target cells.
(7) Such an increase in antibody binding occurred simultaneously with an increase in the fluidity of surface lipid regions, as monitored by fluorescence depolarization of 1-(trimethylammoniophenyl)-6-phenyl-1,3,5-hexatriene.
(8) It has been generally believed that the ligand-binding of steroid hormone receptors triggers an allosteric change in receptor structure, manifested by an increased affinity of the receptor for DNA in vitro and nuclear target elements in vivo, as monitored by nuclear translocation.
(9) Lp(a) also complexes to plasmin-fibrinogen digests, and binding increases in proportion to the time of plasmin-induced fibrinogen degradation.
(10) Theoretical computations are performed of the intercalative binding of the neocarzinostatin chromophore (NCS) with the double-stranded oligonucleotides d(CGCG)2, d(GCGC)2, d(TATA)2 and d(ATAT)2.
(11) The LD50 of the following metal-binding chelating drugs, EDTA, diethylenetriaminepentaacetic acid (DTPA), hydroxyethylenediaminetriacetic acid (HEDTA), cyclohexanediaminotetraacetic acid (CDTA) and triethylenetetraminehexaacetic acid (TTHA) was evaluated in terms of mortality in rats after intraperitoneal administration and was found to be in the order: CDTA greater than EDTA greater than DTPA greater than TTHA greater than HEDTA.
(12) It was also able to inhibit the binding both of alpha-bungarotoxin and rabies virus glycoprotein to the acetylcholine receptor.
(13) We report a series of experiments designed to determine if agents and conditions that have been reported to alter sodium reabsorption, Na-K-ATPase activity or cellular structure in the rat distal nephron might also regulate the density or affinity of binding of 3H-metolazone to the putative thiazide receptor in the distal nephron.
(14) The procedure used in our laboratory was not able to provide accurate determination of the concentrations of these binding forms.
(15) The occupation of the high affinity calcium binding site by Ca(II) and Mn(II) does not influence the Cu(II) binding process, suggesting that there is no direct interaction between this site and the Cu(II) binding sites.
(16) PMN were found to be nonpermissive for HSV replication and were unable to bind virus in the absence of antibody.
(17) Radioligand binding studies revealed the presence of a single class of high-affinity (Kd = 2-6 X 10(-10) M) binding sites for ET-1 in both cells, although the maximal binding capacity of cardiac receptor was about 6- to 12-fold greater than that of vascular receptor.
(18) The transported pIgA was functional, as evidenced by its ability to bind to virus in an ELISA assay and to protect nonimmune mice against intranasal infection with H1N1 but not H3N2 influenza virus.
(19) The monoclonal antibody (mAb), SY38, binds to a cytoplasmic domain of synaptophysin.
(20) Binding data for both ligands to the enzyme yielded nonlinear Scatchard plots that analyze in terms of four negatively cooperative binding sites per enzyme tetramer.
Contract
Definition:
(n.) To draw together or nearer; to reduce to a less compass; to shorten, narrow, or lessen; as, to contract one's sphere of action.
(n.) To draw together so as to wrinkle; to knit.
(n.) To bring on; to incur; to acquire; as, to contract a habit; to contract a debt; to contract a disease.
(n.) To enter into, with mutual obligations; to make a bargain or covenant for.
(n.) To betroth; to affiance.
(n.) To shorten by omitting a letter or letters or by reducing two or more vowels or syllables to one.
(v. i.) To be drawn together so as to be diminished in size or extent; to shrink; to be reduced in compass or in duration; as, iron contracts in cooling; a rope contracts when wet.
(v. i.) To make an agreement; to covenant; to agree; to bargain; as, to contract for carrying the mail.
(a.) Contracted; as, a contract verb.
(a.) Contracted; affianced; betrothed.
(n.) The agreement of two or more persons, upon a sufficient consideration or cause, to do, or to abstain from doing, some act; an agreement in which a party undertakes to do, or not to do, a particular thing; a formal bargain; a compact; an interchange of legal rights.
(n.) A formal writing which contains the agreement of parties, with the terms and conditions, and which serves as a proof of the obligation.
(n.) The act of formally betrothing a man and woman.
Example Sentences:
(1) During the performance of propulsive waves of the oesophagus the implanted vagus nerve caused clonic to tetanic contractions of the sternohyoid muscle, thus proving the oesophagomotor genesis of the reinnervating nerve fibres.
(2) But RWE admitted it had often only been able to retain customers with expired contracts by offering them new deals with more favourable conditions.
(3) Thus adrenaline, via pre- and post-junctional adrenoceptors, may contribute to enhanced vascular smooth muscle contraction, which most likely is sensitized by the elevated intracellular calcium concentration.
(4) Further, the maximal increase in force of contraction was measured using papillary muscle strips from some of these patients.
(5) When subjects centered themselves actively, or additionally, contracted trunk flexor or extensor muscles to predetermined levels of activity, no increase in trunk positioning accuracy was found.
(6) Twitch-tetanus ratios were calculated and found not to be related to unit contraction time.6.
(7) Selective removal of endothelium had no effect on BK-induced contraction or the action of the antagonists.
(8) The increased muscular strength in due to a rise of calcaemia, improved muscle contraction and probably also due to the mentioned nutritional factors.
(9) However, there was not a relationship between the contraction curve of the gallbladder and the bile flow into the duodenum.
(10) In in vitro preparations GABA (10(-7) - 10(-3) M) elicited a dose-dependent relaxation; a decrease in the spontaneous contractions was sometimes observed.
(11) There was no correlation between disturbed gastric clearance, impaired gall bladder contraction, and prolonged colonic transit time in the patients with cardiovascular autonomic neuropathy nor was there a correlation between any disturbed motor function and age or duration of diabetes.
(12) Noradrenaline decreased the phasic contraction amplitude of the circular muscle and exerted a stimulant effect on the tone which suggested an existence of two alpha 1-adrenoceptor subtypes.
(13) It may, however, be useful to compare local wall dynamics in the more isometrically-contracting basal segment with those in the middle portion which brings about most of the emptying of the ventricle.
(14) Upon depletion of ATP in contraction, the P2 intensity reverted to the original rigor level, accompanied by development of rigor tension.
(15) L-NAME abolished B contractions in a dose-dependent fashion.
(16) The power spectrum of the EMG was analyzed during isometric contractions of the shoulder muscles.
(17) A23187 had only a transient effect on KCl-contracted coronary arteries.
(18) When caffeine evokes a contraction, and only then, crayfish muscle fibers become refractory to a second challenge with caffeine for up to 20 min in the standard saline (5 mM K(o)).
(19) Dopamine at concentrations over 10(-5)M induced contractions of tracheal muscle strips and repeated exposures resulted in desensitization (tachyphylaxis) of the muscle.
(20) In the present study we examined cholecystokinin release and gallbladder contraction after oral administration of a commercial fatty meal (Sorbitract; Dagra, Diemen, The Netherlands) using ultrasonography in eight normal subjects and eight gallstone patients before and after 1 and 4 weeks of treatment with ursodeoxycholic acid (10 mg kg-1.day-1).