(1) COP-BLAM III therapy was given to 18 patients with non-Hodgkin's lymphoma, and the therapeutic effects as well as adverse effects of the treatment were examined.
(2) COP-BLAM therapy, which has recently been reported to be useful in the treatment of malignant lymphoma, was performed on aged patients with non-Hodgkin's lymphoma, and the results and adverse effects of the treatment were evaluated.
(3) The course of disease in 61 consecutive patients with non-Hodgkin lymphoma of high grade malignancy, treated between 1979 and 1985 with either CHOP or COP-BLAM regimen, was analysed retrospectively.
(4) A full but short remission set in during a six-drug COP-BLAM treatment regimen.
(5) COP-BLAM III, an outgrowth of studies using infusional therapy, differed from COP-BLAM by using infusional bleomycin and vincristine alternated with bolus vincristine.
(6) By introducing TnblaM into bacterial cells and selecting ampicillin-resistant (ApR) colonies, the subset of isolates producing extracytoplasmic BlaM, and hence containing TnblaM inserted in genes encoding secreted proteins and cell envelope proteins, can be directly selected.
(7) COP-BLAM V employs four to six sequential cycles of infusional chemotherapy tailored to the rapidity of response.
(8) Elderly patients (aged greater than or equal to 65 years) with non-Hodgkin's lymphoma were treated either with CHOP or COP-BLAM therapy, and the effectiveness and reverse effects of COP-BLAM therapy were compared with those of CHOP therapy.
(9) Of 18 patients (median age; 68 years), who were treated with COP-BLAM therapy, 8 had of large lymphoma and 10 medium lymphomas in histopathological classification.
(10) Moreover, the ApR selection that is used with TnblaM can be fine-tuned to obtain blaM fusions to poorly or well-expressed genes.
(11) These regimens, COP-BLAM III, MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, bleomycin), ProMACE-CytaBOM (ProMACE plus cytarabine, bleomycin, vincristine, methotrexate), and high-dose doxorubicin with cytarabine, have produced over 80% CRs and survival plateaus in excess of 60%.
(12) COP-BLAM (cyclophosphamide, vincristine, prednisone, bleomycin, doxorubicin, procarbazine), M-BACOD (methotrexate, bleomycin, doxorubicin, cyclophosphamide, vincristine, dexamethasone), and ProMACE-MOPP (prednisone, methotrexate, doxorubicin, cyclophosphamide, etoposide, mechlorethamine, vincristine, procarbazine, prednisone) have produced CRs in excess of 70% and have demonstrated an increase in survival that has been associated with a concomitant increase in toxicity.
(13) The components of this system are the direct expression vector, pYZ4, and the mature beta-lactamase (BlaM) cassette plasmid, pYZ5, that can be used to generate translational fusions of BlaM to any synthesized membrane protein.
(14) Among 13 patients in advanced stage treated with COP-BLAM therapy, CR was achieved in 11 (84.6%).
(15) Preliminary results in patients with high-risk Hodgkin's disease suggest COP-BLAM V may be effective despite the shortened treatment time.
(16) Various seats and microphones cover the stage: this is a reading, not a stage adaptation; there will be no blood, just a lot of finger-guns and Tarantino yelling "blam-blam-blam!"
(17) Patients in partial remission (PR) or with less of a response to COP-BLAM were switched to IMV.
(18) The fusion protein conferred ampicillin resistance on individual host cells, indicating that the BlaM portion had been translocated to the bacterial periplasm, and that, by inference, the eukaryotic plasma-membrane protein can insert into the bacterial cytoplasmic membrane.
(19) After completion of three courses of COP-BLAM III therapy, which was started on June 7, a partial response was achieved.
(20) TnblaM is a spectinomycin-resistant derivative of Tn5 with an unexpressed open reading frame encoding mature beta-lactamase (BlaM) at its left end.
Blame
Definition:
(v. t.) To censure; to express disapprobation of; to find fault with; to reproach.
(v. t.) To bring reproach upon; to blemish.
(v.) An expression of disapprobation fir something deemed to be wrong; imputation of fault; censure.
(v.) That which is deserving of censure or disapprobation; culpability; fault; crime; sin.
(v.) Hurt; injury.
Example Sentences:
(1) An official inquiry into the Rotherham abuse scandal blamed failings by Rotherham council and South Yorkshire police.
(2) Obiang, blaming foreigners for bringing corruption to his country, told people he needed to run the national treasury to prevent others falling into temptation.
(3) While superheroes like “superman” (21st in SplashData’s 2014 rankings) and “batman” (24th) may be popular choices for passwords, the results if they are cracked could be anything other than super – and users will only have themselves to blame.
(4) The government has blamed a clumsily worded press release for the furore, denying there would be random checks of the public.
(5) He can open doors anywhere and they would at least have someone else to blame.
(6) Doctors have blamed rising levels of type 2 diabetes on the growing number of overweight and obese adults.
(7) It was only up to jurors to decide if the hotel owner, West End Hotel Partners, and former operator, Windsor Capital Group, should share in the blame.
(8) Lisette van Vliet, a senior policy adviser to the Health and Environment Alliance, blamed pressure from the UK and German ministries and industry for delaying public protection from chronic diseases and environmental damage.
(9) The orchestrated round of warnings from the Obama administration did not impress a coterie of senior Republicans who were similarly paraded on the talk shows, blaming the White House for having brought the country to the brink of yet another "manufactured crisis".
(10) And of course, as the articles are shared far and wide across the apparently much-hated web, they become gospel to those who read them and unfortunately become quasi-religious texts to musicians of all stripes who blame the internet for everything that is wrong with their careers.
(11) President Nicolás Maduro has blamed the crisis on the fall in global oil prices, a drought that has hit hydroelectric power generation, and an “economic war” by rightwing businessmen and politicians.
(12) Religious efforts to address the issue have also been complicit in absolving men of their crimes, objectifying women and doing more harm than good with campaigns that blame women for the phenomenon.
(13) Our failure to understand kidney function in the neonate does not justify shifting the blame for unwanted disturbances in fluid and electrolyte balance, metabolic acidosis, and azotemia to a small kidney.
(14) Communal riots are not unique to Gujarat, but the chief ministers of other states have not been blamed when pogroms have erupted on their watch.
(15) If Thatcher's government is in part to blame, then Bill Clinton's is even more so; driven by a desire to let every American own their own home, it was Clinton's decision to create the ill-fated sub-prime mortgage system .
(16) OPM hack: China blamed for massive breach at US federal agency Read more The full scale of the information the attackers accessed remains unknown but could include highly sensitive data such as medical records, employment files and financial details, as well as information on security clearances and more.
(17) We continue to offer customers a great range of beer, lager and cider.” Heineken’s bid to raise prices for its products in supermarkets comes just a few months after it put 6p on a pint in pubs , a decision it blamed on the weak pound.
(18) I can’t stay here anymore.” When his mother calls, he says, he refuses to talk to her, blaming her in part for his predicament.
(19) A sclerotic patriarchal social system is also to blame.
(20) Engie, the owner of Rugeley coal-fired station in Staffordshire, which made the most recent closure announcement earlier this month, blamed low wholesale power prices as much as carbon taxes for its decision .